tet(S)

Download Sequences

Accession	ARO:3000192
Synonym(s)	tetS
CARD Short Name	tet(S)
Definition	Tet(S) is a ribosomal protection protein found in Gram-positive and Gram-negative strains. It is similar to tet(M) and tet(O).
AMR Gene Family	tetracycline-resistant ribosomal protection protein
Drug Class	tetracycline antibiotic
Resistance Mechanism	antibiotic target protection
Resistomes with Perfect Matches	Enterococcus faecalis^g+p+wgs, Enterococcus faecium^g+p, Lactococcus garvieae^p, Listeria innocua^p, Staphylococcus aureus^g+p
Resistomes with Sequence Variants	Enterococcus avium^wgs, Enterococcus faecalis^g+p+wgs, Enterococcus faecium^g+p+wgs+gi, Enterococcus hirae^g+wgs, Klebsiella quasipneumoniae^wgs, Lactococcus garvieae^p+wgs, Listeria innocua^p, Staphylococcus aureus^g+p+wgs, Streptococcus agalactiae^wgs, Streptococcus canis^g+wgs, Streptococcus iniae^wgs, Streptococcus pneumoniae^wgs, Streptococcus pyogenes^wgs, Streptococcus suis^wgs, Streptococcus uberis^wgs
Classification	7 ontology terms \| Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic target protection [Resistance Mechanism] + antibiotic target protection protein + tetracycline antibiotic [Drug Class]
Parent Term(s)	7 ontology terms \| Show + tetracycline-resistant ribosomal protection protein [AMR Gene Family] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic doxycycline [Antibiotic] + confers_resistance_to_antibiotic minocycline [Antibiotic] + confers_resistance_to_antibiotic chlortetracycline [Antibiotic] + confers_resistance_to_antibiotic demeclocycline [Antibiotic] + confers_resistance_to_antibiotic oxytetracycline [Antibiotic]
Publications	Charpentier E, et al. 1994. Antimicrob Agents Chemother 38(10): 2330-2335. Presence of the Listeria tetracycline resistance gene tet(S) in Enterococcus faecalis. (PMID 7840565) Charpentier E, et al. 1993. Gene 131(1): 27-34. Characterization of a new class of tetracycline-resistance gene tet(S) in Listeria monocytogenes BM4210. (PMID 8370538)

Resistomes

Prevalence of tet(S) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

Species	NCBI Chromosome	NCBI Plasmid	NCBI WGS	NCBI GI	GRDI-AMR2
Enterococcus avium	0%	0%	1.75%	0%	0%
Enterococcus avium	0%	0%	0%	0%	0%
Enterococcus faecalis	1.82%	0.25%	1.93%	0%	0%
Enterococcus faecalis	1.82%	0.25%	0.16%	0%	0%
Enterococcus faecium	0.64%	1.17%	1.49%	1.96%	0%
Enterococcus faecium	0.64%	0.26%	0%	0%	0%
Enterococcus hirae	0%	0%	0%	0%	0%
Enterococcus hirae	3.85%	0%	0.46%	0%	0%
Klebsiella quasipneumoniae	0%	0%	0.13%	0%	0%
Klebsiella quasipneumoniae	0%	0%	0%	0%	0%
Lactococcus garvieae	0%	4.17%	0%	0%	0%
Lactococcus garvieae	0%	4.17%	17.78%	0%	0%
Listeria innocua	0%	15.79%	0%	0%	0%
Listeria innocua	0%	15.79%	0%	0%	0%
Staphylococcus aureus	0.7%	0.11%	0.01%	0%	0%
Staphylococcus aureus	0.7%	0.11%	0%	0%	0%
Streptococcus agalactiae	0%	0%	0%	0%	0%
Streptococcus agalactiae	0%	0%	0.9%	0%	0%
Streptococcus canis	16.67%	0%	6.67%	0%	0%
Streptococcus canis	0%	0%	0%	0%	0%
Streptococcus iniae	0%	0%	0%	0%	0%
Streptococcus iniae	0%	0%	1.16%	0%	0%
Streptococcus pneumoniae	0%	0%	0%	0%	0%
Streptococcus pneumoniae	0%	0%	0.03%	0%	0%
Streptococcus pyogenes	0%	0%	0.05%	0%	0%
Streptococcus pyogenes	0%	0%	0%	0%	0%
Streptococcus suis	0%	0%	0.05%	0%	0%
Streptococcus suis	0%	0%	0%	0%	0%
Streptococcus uberis	0%	0%	0%	0%	0%
Streptococcus uberis	0%	0%	2.68%	0%	0%

Show Perfect Only

Detection Models

protein homolog model

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 300

Protein
DNA

>gb|AAA25293.1|+|tet(S) [Listeria monocytogenes]
MKIINIGILAHVDAGKTTLTESLLYSSGAIKELGSVDSGTTKTDTMFLERQRGITIQTAITSFQRENVKVNIVDTPGHMDFLADVYRSLS
VLDGAILLISAKDGVQSQTRILFHALRKMNIPIIFFINKIDQNGINLPDVYQDIKDKLSDDIIIKQTVNLNLKPYVIDYTEPEQWETVIV
GNDYLLEKYTIGKTLNIAELEKEENERIQSCSLYPVYHGSAKNNIGIKQLIEVITSKLFSPTQLNSDKLCGNVFKVEYSDDGQRLVYVRL
YSGTLHLRDSVNISEKEKIKVTEMYTSINGELRQIDKAEPGEIIILKNELLKLNNVLGDKKRLPHREILENPLPMLQTTIEPCKSVQREK
LLDALFEISDSDPLLQYYVDTVTHEIVLSFLGEVQMEVTCTLIQEKYHIEIETRKPTVIYMERPLKKSEFTIDIEVPPNPFWASIGLSVT
PLPLGSGIQYESLVSLGYLNQSFQNAVMEGIRYGCEQGLYGWKLTDCKICFKYGLYYSPVSTPADFRMLAPIVLEQAFRKSGTELLEPYL
SFEIYVPQEYLSRAYNDASKYCANILNTKLKGNEVILIGEIPARCIQEYRNSLTFFTNGRSVCLTELKGYQVTNIKSAFQPRRPNNRIDK
VRHMFNKINLH

>gb|L09756.1|+|1-1926|tet(S) [Listeria monocytogenes]
TTGAAAATTATTAATATCGGTATCTTAGCACATGTTGATGCAGGAAAAACTACTTTGACAGAAAGCTTACTATACAGTAGCGGAGCAATT
AAAGAGTTAGGAAGTGTAGATAGCGGTACAACGAAAACGGATACTATGTTTTTGGAACGCCAGAGAGGTATTACTATTCAGACCGCAATA
ACATCTTTTCAACGGGAAAATGTTAAAGTAAATATTGTAGATACTCCTGGACACATGGATTTTTTGGCAGATGTATACCGTTCATTATCT
GTTTTGGATGGAGCTATTTTGCTAATCTCTGCAAAAGATGGAGTACAGTCACAAACTCGTATACTATTCCATGCACTTAGAAAGATGAAC
ATACCTATAATATTTTTTATTAACAAAATTGATCAAAATGGAATAAATTTGCCAGATGTTTATCAAGATATTAAGGACAAACTTTCTGAC
GACATCATAATTAAGCAGACTGTGAATCTAAATTTGAAACCTTATGTAATAGATTATACTGAACCAGAACAATGGGAGACAGTAATTGTG
GGAAATGATTATTTATTAGAAAAATATACCATTGGGAAAACATTGAATATTGCAGAACTTGAAAAGGAGGAAAACGAAAGAATTCAAAGT
TGCTCCTTATATCCTGTTTATCACGGAAGTGCAAAGAATAATATTGGAATTAAACAACTTATAGAGGTAATTACTAGCAAATTATTTTCA
CCCACACAACTCAATTCAGATAAACTTTGTGGAAATGTTTTTAAAGTAGAATATTCAGATGATGGTCAACGGCTTGTCTATGTACGTCTT
TATAGTGGAACGCTACATTTGCGAGACTCAGTCAATATATCAGAAAAGGAAAAAATAAAAGTTACAGAAATGTATACTTCAATAAATGGA
GAATTACGCCAGATAGATAAGGCAGAGCCTGGTGAGATTATTATTTTAAAAAATGAGCTTTTAAAACTAAATAACGTACTTGGAGATAAA
AAAAGATTACCACATAGAGAAATTCTTGAGAATCCTCTTCCTATGTTACAAACAACAATTGAACCATGTAAATCAGTACAAAGAGAAAAG
TTACTAGATGCACTTTTTGAAATATCCGATAGTGATCCCCTTCTACAATATTATGTAGATACAGTAACTCACGAAATTGTGCTATCTTTT
TTAGGTGAGGTCCAAATGGAGGTAACTTGTACTCTGATTCAAGAAAAATATCATATTGAGATAGAAACAAGAAAACCAACTGTCATTTAT
ATGGAAAGACCATTAAAAAAATCTGAATTTACCATTGATATCGAAGTACCTCCAAATCCTTTCTGGGCTTCTATTGGTTTATCTGTAACA
CCACTTCCTTTGGGTAGTGGCATTCAGTATGAGAGCCTGGTTTCTCTAGGTTATTTAAATCAATCATTTCAAAATGCAGTTATGGAAGGT
ATACGCTATGGGTGTGAACAAGGATTGTACGGTTGGAAATTAACAGACTGTAAGATCTGTTTTAAGTATGGTCTATATTACAGCCCTGTC
AGTACGCCAGCAGATTTCCGAATGCTTGCGCCTATTGTACTAGAGCAGGCTTTTAGAAAGAGTGGTACAGAGTTATTAGAGCCATATCTT
AGCTTCGAAATTTATGTACCACAAGAATATCTTTCGAGAGCATATAATGATGCTTCCAAATATTGTGCAAATATTTTAAATACTAAGTTA
AAAGGTAACGAGGTCATTCTCATTGGTGAAATTCCAGCCCGTTGTATTCAAGAGTATCGAAACAGTTTAACTTTCTTTACAAATGGACGC
AGTGTCTGTTTAACAGAGTTAAAAGGTTATCAGGTTACTAACATTAAGTCTGCTTTCCAACCACGTCGTCCAAATAATAGAATAGACAAA
GTAAGGCATATGTTTAATAAAATCAACTTACATTGA

Curator Acknowledgements

Curator	Description	Most Recent Edit

tet(S)

Prevalence: protein homolog model (view sequences)

Graph