| Accession | ARO:3000192 |
| Synonym(s) | tetS |
| CARD Short Name | tet(S) |
| Definition | Tet(S) is a ribosomal protection protein found in Gram-positive and Gram-negative strains. It is similar to tet(M) and tet(O). |
| AMR Gene Family | tetracycline-resistant ribosomal protection protein |
| Drug Class | tetracycline antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Perfect Matches | Enterococcus faecalisg+p+wgs, Enterococcus faeciumg+p, Lactococcus garvieaep, Listeria innocuap, Staphylococcus aureusg+p |
| Resistomes with Sequence Variants | Enterococcus aviumwgs, Enterococcus faecalisg+p+wgs, Enterococcus faeciumg+p+wgs+gi, Enterococcus hiraeg+wgs, Klebsiella quasipneumoniaewgs, Lactococcus garvieaep+wgs, Listeria innocuap, Staphylococcus aureusg+p+wgs, Streptococcus agalactiaewgs, Streptococcus canisg+wgs, Streptococcus iniaewgs, Streptococcus pneumoniaewgs, Streptococcus pyogeneswgs, Streptococcus suiswgs, Streptococcus uberiswgs |
| Classification | 7 ontology terms | Show |
| Parent Term(s) | 7 ontology terms | Show + tetracycline-resistant ribosomal protection protein [AMR Gene Family] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic doxycycline [Antibiotic] + confers_resistance_to_antibiotic minocycline [Antibiotic] + confers_resistance_to_antibiotic chlortetracycline [Antibiotic] + confers_resistance_to_antibiotic demeclocycline [Antibiotic] + confers_resistance_to_antibiotic oxytetracycline [Antibiotic] |
| Publications | Charpentier E, et al. 1994. Antimicrob Agents Chemother 38(10): 2330-2335. Presence of the Listeria tetracycline resistance gene tet(S) in Enterococcus faecalis. (PMID 7840565) Charpentier E, et al. 1993. Gene 131(1): 27-34. Characterization of a new class of tetracycline-resistance gene tet(S) in Listeria monocytogenes BM4210. (PMID 8370538) |
Prevalence of tet(S) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Enterococcus avium | 0% | 0% | 1.75% | 0% |
| Enterococcus faecalis | 1.82% | 0.25% | 1.52% | 0% |
| Enterococcus faecium | 0.64% | 1.17% | 1.39% | 1.96% |
| Enterococcus hirae | 3.85% | 0% | 0.46% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.13% | 0% |
| Lactococcus garvieae | 0% | 4.17% | 15.56% | 0% |
| Listeria innocua | 0% | 15.79% | 0% | 0% |
| Staphylococcus aureus | 0.7% | 0.11% | 0.01% | 0% |
| Streptococcus agalactiae | 0% | 0% | 0.52% | 0% |
| Streptococcus canis | 16.67% | 0% | 6.67% | 0% |
| Streptococcus iniae | 0% | 0% | 1.16% | 0% |
| Streptococcus pneumoniae | 0% | 0% | 0.02% | 0% |
| Streptococcus pyogenes | 0% | 0% | 0.05% | 0% |
| Streptococcus suis | 0% | 0% | 0.05% | 0% |
| Streptococcus uberis | 0% | 0% | 1.79% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300