tet(M)

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Accession ARO:3000186
Synonym(s)tetM
CARD Short Nametet(M)
DefinitionTet(M) is a ribosomal protection protein that confers tetracycline resistance. It is found on transposable DNA elements and its horizontal transfer between bacterial species has been documented.
AMR Gene Familytetracycline-resistant ribosomal protection protein
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Perfect MatchesClostridioides difficilegi, Enterococcus aviumgi, Enterococcus casseliflavusgi, Enterococcus faecalisgi, Enterococcus faeciumgi, Gardnerella vaginalisgi, Lactobacillus inersgi, Listeria innocuagi, Parvimonas micragi, Peptoniphilus hareigi, Staphylococcus aureusgi, Streptococcus porcinusgi, Streptococcus pyogenesgi
Resistomes with Sequence VariantsAcinetobacter baumanniig+p+wgs+gi, Acinetobacter townerip, Aliarcobacter butzlerip+wgs, Anaerococcus mediterraneensisg+gi, Anaerostipes hadrusg+wgs, Bacillus cereuswgs, Bacillus subtilisg+gi, Bacillus thuringiensiswgs, Bacillus velezensiswgs, Bifidobacterium brevewgs, Blautia productag+gi, Campylobacter coliwgs, Campylobacter ureolyticuswgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Clostridioides difficilegi, Clostridium botulinumwgs, Clostridium perfringensg+wgs, Clostridium sporogenesg+wgs, Enterobacter hormaecheiwgs, Enterococcus aviumg+wgs+gi, Enterococcus casseliflavusgi, Enterococcus faecalisg+p+wgs+gi, Enterococcus faeciumg+p+wgs+gi, Enterococcus hiraeg+p+wgs, Erysipelatoclostridium ramosumg+wgs, Erysipelothrix rhusiopathiaeg+gi, Escherichia albertiiwgs, Escherichia colig+p+wgs, Escherichia fergusoniig+p+wgs, Eubacterium maltosivoranswgs, Fusobacterium necrophorumwgs, Fusobacterium nucleatumg+wgs, Gardnerella vaginalisg+wgs+gi, Gemella haemolysanswgs, Gemella morbillorumg+wgs, Haemophilus parainfluenzaewgs, Histophilus somniwgs, Jeotgalibaca ciconiaeg+gi, Jeotgalibaca porcig, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Lactobacillus gasseriwgs, Lactobacillus inersg+wgs+gi, Lactococcus garvieaep+wgs, Ligilactobacillus animaliswgs, Listeria innocuag+wgs+gi, Listeria monocytogenesg+wgs+gi, Megasphaera stantoniiwgs, Mycoplasma mycoidesg+gi, Neisseria gonorrhoeaep+wgs, Neisseria meningitidiswgs, Neisseria siccag, Parvimonas micrag+wgs+gi, Peptoniphilus hareig+wgs+gi, Proteus mirabiliswgs, Providencia rettgeriwgs, Salmonella entericag+p+wgs+gi, Shigella boydiiwgs, Shigella flexnerip, Shigella sonneiwgs, Staphylococcus aureusg+p+wgs+gi, Staphylococcus capitisg+wgs, Staphylococcus epidermidiswgs, Staphylococcus haemolyticusg+wgs, Staphylococcus hominiswgs, Staphylococcus pseudintermediusg+wgs+gi, Staphylococcus saprophyticuswgs, Staphylococcus simulanswgs, Streptococcus agalactiaeg+wgs+gi, Streptococcus anginosusg+wgs, Streptococcus canisg+wgs+gi, Streptococcus constellatusg+wgs, Streptococcus cristatusg+wgs+gi, Streptococcus dysgalactiaeg+wgs, Streptococcus equiwgs, Streptococcus equinusgi, Streptococcus gallolyticusg+wgs, Streptococcus gordoniig+wgs, Streptococcus gwangjuenseg+gi, Streptococcus iniaewgs, Streptococcus intermediusg+wgs, Streptococcus lutetiensisg+wgs+gi, Streptococcus mitisg+wgs, Streptococcus mutanswgs, Streptococcus pasteurianusg+wgs+gi, Streptococcus pneumoniaeg+wgs+gi, Streptococcus porcinusg+wgs+gi, Streptococcus pseudopneumoniaeg+wgs, Streptococcus pseudoporcinusg+wgs+gi, Streptococcus pyogenesg+wgs+gi, Streptococcus sanguiniswgs, Streptococcus suisg+wgs+gi, Streptococcus uberiswgs, Vibrio alginolyticuswgs, Vibrio choleraewgs, Vibrio harveyip, Vibrio parahaemolyticusp+wgs, Vibrio vulnificuswgs
Classification7 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ tetracycline-resistant ribosomal protection protein [AMR Gene Family]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic doxycycline [Antibiotic]
+ confers_resistance_to_antibiotic minocycline [Antibiotic]
+ confers_resistance_to_antibiotic chlortetracycline [Antibiotic]
+ confers_resistance_to_antibiotic demeclocycline [Antibiotic]
+ confers_resistance_to_antibiotic oxytetracycline [Antibiotic]
Publications

Akhtar M, et al. 2009. Microb Ecol 58(3): 509-518. Horizontal transfer of the tetracycline resistance gene tetM mediated by pCF10 among Enterococcus faecalis in the house fly (Musca domestica L.) alimentary canal. (PMID 19475445)
Resistomes

Prevalence of tet(M) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Acinetobacter baumannii0.18%0.16%0.03%0.63%0%
Acinetobacter towneri0%6.25%0%0%0%
Aliarcobacter butzleri0%66.67%0.81%0%0%
Anaerococcus mediterraneensis100%0%0%100%0%
Anaerostipes hadrus66.67%0%8.62%0%0%
Bacillus cereus0%0%0.1%0%0%
Bacillus subtilis0.72%0%0%2.74%0%
Bacillus thuringiensis0%0%0.17%0%0%
Bacillus velezensis0%0%0.37%0%0%
Bifidobacterium breve0%0%0.6%0%0%
Blautia producta33.33%0%0%100%0%
Campylobacter coli0%0%0.79%0%0%
Campylobacter ureolyticus0%0%6.9%0%0%
Citrobacter werkmanii0%0%2.56%0%0%
Citrobacter youngae0%0%6.25%0%0%
Clostridioides difficile0%0%0%33.33%0%
Clostridium botulinum0%0%0.27%0%0%
Clostridium perfringens1.25%0%0.49%0%0%
Clostridium sporogenes8.33%0%0.85%0%0%
Enterobacter hormaechei0%0%0.09%0%0%
Enterococcus avium66.67%0%66.67%100%0%
Enterococcus casseliflavus0%0%0%100%0%
Enterococcus faecalis36.36%14.29%61.55%37.5%0%
Enterococcus faecium50%4.79%59.35%45.1%0%
Enterococcus hirae7.69%23.81%25.46%0%0%
Erysipelatoclostridium ramosum20%0%54.65%0%0%
Erysipelothrix rhusiopathiae27.27%0%0%66.67%0%
Escherichia albertii0%0%0.65%0%0%
Escherichia coli0.1%0.74%3.35%0%0.04%
Escherichia fergusonii1.64%0.71%5.43%0%0%
Eubacterium maltosivorans0%0%33.33%0%0%
Fusobacterium necrophorum0%0%6.98%0%0%
Fusobacterium nucleatum8.33%0%8.82%0%0%
Gardnerella vaginalis26.67%0%18.45%100%0%
Gemella haemolysans0%0%25%0%0%
Gemella morbillorum33.33%0%25%0%0%
Haemophilus parainfluenzae0%0%2.44%0%0%
Histophilus somni0%0%3.45%0%0%
Jeotgalibaca ciconiae100%0%0%100%0%
Jeotgalibaca porci100%0%0%0%0%
Klebsiella pneumoniae0%0.06%0.1%0%0%
Klebsiella quasipneumoniae0%0%0.26%0%0%
Lactobacillus gasseri0%0%1.92%0%0%
Lactobacillus iners71.43%0%62.9%100%0%
Lactococcus garvieae0%4.17%4.44%0%0%
Ligilactobacillus animalis0%0%25%0%0%
Listeria innocua17.65%0%18.8%100%0%
Listeria monocytogenes1.4%0%1.75%100%0%
Megasphaera stantonii0%0%25%0%0%
Mycoplasma mycoides40%0%0%89.47%0%
Neisseria gonorrhoeae0%8.67%17.56%0%0%
Neisseria meningitidis0%0%0.09%0%0%
Neisseria sicca33.33%0%0%0%0%
Parvimonas micra30%0%25%100%0%
Peptoniphilus harei100%0%71.43%100%0%
Proteus mirabilis0%0%0.33%0%0%
Providencia rettgeri0%0%3.82%0%0%
Salmonella enterica0.25%1.64%0.62%0.66%0%
Shigella boydii0%0%3.33%0%0%
Shigella flexneri0%2.01%0%0%0%
Shigella sonnei0%0%0.73%0%0%
Staphylococcus aureus12.13%0.19%13.25%7.16%0%
Staphylococcus capitis10%0%3.16%0%0%
Staphylococcus epidermidis0%0%0.67%0%0%
Staphylococcus haemolyticus6.9%0%2.2%0%0%
Staphylococcus hominis0%0%0.98%0%0%
Staphylococcus pseudintermedius40%0%45.13%13.33%0%
Staphylococcus saprophyticus0%0%0.7%0%0%
Staphylococcus simulans0%0%3.39%0%0%
Streptococcus agalactiae53.27%0%57.41%66.67%0%
Streptococcus anginosus35.29%0%30.41%0%0%
Streptococcus canis33.33%0%13.33%100%0%
Streptococcus constellatus37.5%0%45.45%0%0%
Streptococcus cristatus75%0%31.43%100%0%
Streptococcus dysgalactiae4%0%21.5%0%0%
Streptococcus equi0%0%0.68%0%0%
Streptococcus equinus0%0%0%66.67%0%
Streptococcus gallolyticus50%0%27.27%0%0%
Streptococcus gordonii14.29%0%23.08%0%0%
Streptococcus gwangjuense100%0%0%100%0%
Streptococcus iniae0%0%1.16%0%0%
Streptococcus intermedius14.29%0%29.55%0%0%
Streptococcus lutetiensis28.57%0%38.78%100%0%
Streptococcus mitis44.44%0%17.68%0%0%
Streptococcus mutans0%0%0.39%0%0%
Streptococcus pasteurianus50%0%80%33.33%0%
Streptococcus pneumoniae33.98%0%37.52%12.5%0%
Streptococcus porcinus16.67%0%66.67%100%0%
Streptococcus pseudopneumoniae100%0%47.46%0%0%
Streptococcus pseudoporcinus33.33%0%28.57%100%0%
Streptococcus pyogenes14.55%0%26.3%81.82%0%
Streptococcus sanguinis0%0%25.77%0%0%
Streptococcus suis14.4%0%27.18%16.67%0%
Streptococcus uberis0%0%6.25%0%0%
Vibrio alginolyticus0%0%1.19%0%0%
Vibrio cholerae0%0%0.19%0%0%
Vibrio harveyi0%14.29%0%0%0%
Vibrio parahaemolyticus0%0.31%0.41%0%0%
Vibrio vulnificus0%0%0.41%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 300


>gb|BAB82500.1|+|tet(M) [Erysipelothrix rhusiopathiae]
MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLS
VLDGAILLISAKDGVQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWDTVIE
GNDDLLEKYTSGKLLEALELEQEESIRFHNCSLFPVYHGSAKNNIGIDNLIEVITNKFYSSTHRGQSELCGKVFKIEYTKKRQRLAYIRL
YSGVLHLRDSVRVSEKEKIKVTEMYTSINGELCKIDRAYSGEIVILQNEFLKLNSVLGDTKLLPQRKKIENPHPLLQTTVEPSKPEQREM
LLDALLEISDSDPLLRYYVDSTTHEIILSFLGKVQMEVISALLQEKYHVEIELKEPTVIYMERPLKNAEYTIHIEVPPNPFWASIGLSVS
PLPLGSGMQYESSVSLGYLNQSFQNAVMEGIRYGCEQGLYGWNVTDCKICFKYGLYYSPVSTPADFRMLAPIVLEQVLKKAGTELLEPYL
SFKIYAPQEYLSRAYNDAPKYCANIVDTQLKNNEVILSGEIPARCIQEYRSDLTFFTNGRSVCLTELKGYHVTTGEPVCQPRRPNSRIDK
VRYMFNKIT


>gb|AB039845.1|+|26-1945|tet(M) [Erysipelothrix rhusiopathiae]
ATGAAAATTATTAATATTGGAGTTTTAGCTCATGTTGATGCGGGAAAAACTACCTTAACAGAAAGCTTATTATATAACAGTGGAGCGATT
ACAGAATTAGGAAGCGTGGACAAAGGTACAACGAGGACGGATAATACGCTTTTAGAACGTCAGAGAGGAATTACAATTCAGACAGGAATA
ACCTCTTTTCAGTGGGAAAATACGAAGGTGAACATCATAGACACGCCAGGACATATGGATTTCTTAGCAGAAGTATATCGTTCATTATCA
GTTTTAGATGGGGCAATTCTACTGATTTCTGCAAAAGATGGCGTACAAGCACAAACTCGTATATTATTTCATGCACTTAGGAAAATGGGG
ATTCCCACAATCTTTTTTATCAATAAGATTGACCAAAATGGAATTGATTTATCAACGGTTTATCAGGATATTAAAGAGAAACTTTCTGCC
GAAATTGTAATCAAACAGAAGGTAGAACTGTATCCTAATATGTGTGTGACGAACTTTACCGAATCTGAACAATGGGATACGGTAATAGAG
GGAAACGATGACCTTTTAGAGAAATATACGTCTGGGAAATTATTGGAAGCATTAGAACTCGAACAAGAGGAAAGCATAAGATTTCATAAT
TGTTCCCTGTTCCCTGTTTATCACGGAAGTGCAAAAAACAATATAGGGATTGATAACCTTATAGAAGTGATTACGAATAAATTTTATTCA
TCAACACATCGAGGTCAGTCTGAACTTTGCGGAAAAGTTTTCAAAATTGAATATACAAAAAAAAGACAACGTCTTGCATATATACGCCTT
TATAGTGGAGTACTACATTTACGAGATTCGGTTAGAGTATCAGAAAAAGAAAAAATAAAAGTTACAGAAATGTATACTTCAATAAATGGT
GAATTATGTAAGATTGATAGAGCTTATTCTGGAGAAATTGTTATTTTGCAAAATGAGTTTTTGAAGTTAAATAGTGTTCTTGGAGATACA
AAACTATTGCCACAGAGAAAAAAGATTGAAAATCCGCACCCTCTACTACAAACAACTGTTGAACCGAGTAAACCTGAACAGAGAGAAATG
TTGCTTGATGCCCTTTTGGAAATCTCAGATAGTGATCCGCTTCTACGATATTACGTGGATTCTACGACACATGAAATTATACTTTCTTTC
TTAGGGAAAGTACAAATGGAAGTGATTAGTGCACTGTTGCAAGAAAAGTATCATGTGGAGATAGAACTAAAAGAGCCTACAGTCATTTAT
ATGGAGAGACCGTTAAAAAATGCAGAATATACCATTCACATCGAAGTGCCGCCAAATCCTTTCTGGGCTTCCATTGGTTTATCTGTATCA
CCGCTTCCGTTGGGAAGTGGAATGCAGTATGAGAGCTCGGTTTCTCTTGGATACTTAAATCAATCATTTCAAAATGCAGTTATGGAGGGG
ATACGCTATGGCTGTGAACAAGGATTGTATGGTTGGAATGTGACGGACTGTAAAATCTGTTTTAAGTATGGCTTATACTATAGCCCTGTT
AGTACCCCAGCAGATTTTCGGATGCTTGCTCCTATTGTATTGGAACAAGTCTTAAAAAAAGCTGGAACAGAATTGTTAGAGCCATATCTT
AGTTTTAAAATTTATGCGCCACAGGAATATCTTTCACGAGCATACAACGATGCTCCTAAATATTGTGCGAACATCGTAGACACTCAATTG
AAAAATAATGAGGTCATTCTTAGTGGAGAAATCCCTGCTCGGTGTATTCAAGAATATCGTAGTGATTTAACTTTCTTTACAAATGGACGT
AGTGTTTGTTTAACAGAGTTAAAAGGGTACCATGTTACTACCGGTGAACCTGTTTGCCAGCCCCGTCGTCCAAATAGTCGGATAGATAAA
GTACGATATATGTTCAATAAAATAACTTAG

Curator Acknowledgements
Curator Description Most Recent Edit