| Accession | ARO:3000186 |
| Synonym(s) | tetM |
| CARD Short Name | tet(M) |
| Definition | Tet(M) is a ribosomal protection protein that confers tetracycline resistance. It is found on transposable DNA elements and its horizontal transfer between bacterial species has been documented. |
| AMR Gene Family | tetracycline-resistant ribosomal protection protein |
| Drug Class | tetracycline antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Perfect Matches | Clostridioides difficilegi, Enterococcus aviumgi, Enterococcus casseliflavusgi, Enterococcus faecalisgi, Enterococcus faeciumgi, Gardnerella vaginalisgi, Lactobacillus inersgi, Listeria innocuagi, Parvimonas micragi, Peptoniphilus hareigi, Staphylococcus aureusgi, Streptococcus porcinusgi, Streptococcus pyogenesgi |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+p+wgs+gi, Acinetobacter townerip, Aliarcobacter butzlerip+wgs, Anaerococcus mediterraneensisg+gi, Anaerostipes hadrusg+wgs, Bacillus cereuswgs, Bacillus subtilisg+gi, Bacillus thuringiensiswgs, Bacillus velezensiswgs, Bifidobacterium brevewgs, Blautia productag+gi, Campylobacter coliwgs, Campylobacter ureolyticuswgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Clostridioides difficilegi, Clostridium botulinumwgs, Clostridium perfringensg+wgs, Clostridium sporogenesg+wgs, Enterobacter hormaecheiwgs, Enterococcus aviumg+wgs+gi, Enterococcus casseliflavusgi, Enterococcus faecalisg+p+wgs+gi, Enterococcus faeciumg+p+wgs+gi, Enterococcus hiraeg+p+wgs, Erysipelatoclostridium ramosumg+wgs, Erysipelothrix rhusiopathiaeg+gi, Escherichia albertiiwgs, Escherichia colig+p+wgs, Escherichia fergusoniig+p+wgs, Eubacterium maltosivoranswgs, Fusobacterium necrophorumwgs, Fusobacterium nucleatumg+wgs, Gardnerella vaginalisg+wgs+gi, Gemella haemolysanswgs, Gemella morbillorumg+wgs, Haemophilus parainfluenzaewgs, Histophilus somniwgs, Jeotgalibaca ciconiaeg+gi, Jeotgalibaca porcig, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Lactobacillus gasseriwgs, Lactobacillus inersg+wgs+gi, Lactococcus garvieaep+wgs, Ligilactobacillus animaliswgs, Listeria innocuag+wgs+gi, Listeria monocytogenesg+wgs+gi, Megasphaera stantoniiwgs, Mycoplasma mycoidesg+gi, Neisseria gonorrhoeaep+wgs, Neisseria meningitidiswgs, Neisseria siccag, Parvimonas micrag+wgs+gi, Peptoniphilus hareig+wgs+gi, Proteus mirabiliswgs, Providencia rettgeriwgs, Salmonella entericag+p+wgs+gi, Shigella boydiiwgs, Shigella flexnerip, Shigella sonneiwgs, Staphylococcus aureusg+p+wgs+gi, Staphylococcus capitisg+wgs, Staphylococcus epidermidiswgs, Staphylococcus haemolyticusg+wgs, Staphylococcus hominiswgs, Staphylococcus pseudintermediusg+wgs+gi, Staphylococcus saprophyticuswgs, Staphylococcus simulanswgs, Streptococcus agalactiaeg+wgs+gi, Streptococcus anginosusg+wgs, Streptococcus canisg+wgs+gi, Streptococcus constellatusg+wgs, Streptococcus cristatusg+wgs+gi, Streptococcus dysgalactiaeg+wgs, Streptococcus equiwgs, Streptococcus equinusgi, Streptococcus gallolyticusg+wgs, Streptococcus gordoniig+wgs, Streptococcus gwangjuenseg+gi, Streptococcus iniaewgs, Streptococcus intermediusg+wgs, Streptococcus lutetiensisg+wgs+gi, Streptococcus mitisg+wgs, Streptococcus mutanswgs, Streptococcus pasteurianusg+wgs+gi, Streptococcus pneumoniaeg+wgs+gi, Streptococcus porcinusg+wgs+gi, Streptococcus pseudopneumoniaeg+wgs, Streptococcus pseudoporcinusg+wgs+gi, Streptococcus pyogenesg+wgs+gi, Streptococcus sanguiniswgs, Streptococcus suisg+wgs+gi, Streptococcus uberiswgs, Vibrio alginolyticuswgs, Vibrio choleraewgs, Vibrio harveyip, Vibrio parahaemolyticusp+wgs, Vibrio vulnificuswgs |
| Classification | 7 ontology terms | Show |
| Parent Term(s) | 7 ontology terms | Show + tetracycline-resistant ribosomal protection protein [AMR Gene Family] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic doxycycline [Antibiotic] + confers_resistance_to_antibiotic minocycline [Antibiotic] + confers_resistance_to_antibiotic chlortetracycline [Antibiotic] + confers_resistance_to_antibiotic demeclocycline [Antibiotic] + confers_resistance_to_antibiotic oxytetracycline [Antibiotic] |
| Publications | Akhtar M, et al. 2009. Microb Ecol 58(3): 509-518. Horizontal transfer of the tetracycline resistance gene tetM mediated by pCF10 among Enterococcus faecalis in the house fly (Musca domestica L.) alimentary canal. (PMID 19475445) |
Prevalence of tet(M) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0.18% | 0.16% | 0.03% | 0.63% |
| Acinetobacter towneri | 0% | 6.25% | 0% | 0% |
| Aliarcobacter butzleri | 0% | 66.67% | 0.81% | 0% |
| Anaerococcus mediterraneensis | 100% | 0% | 0% | 100% |
| Anaerostipes hadrus | 66.67% | 0% | 8.62% | 0% |
| Bacillus cereus | 0% | 0% | 0.1% | 0% |
| Bacillus subtilis | 0.72% | 0% | 0% | 2.74% |
| Bacillus thuringiensis | 0% | 0% | 0.17% | 0% |
| Bacillus velezensis | 0% | 0% | 0.37% | 0% |
| Bifidobacterium breve | 0% | 0% | 0.6% | 0% |
| Blautia producta | 33.33% | 0% | 0% | 100% |
| Campylobacter coli | 0% | 0% | 0.53% | 0% |
| Campylobacter ureolyticus | 0% | 0% | 6.9% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Citrobacter youngae | 0% | 0% | 6.25% | 0% |
| Clostridioides difficile | 0% | 0% | 0% | 33.33% |
| Clostridium botulinum | 0% | 0% | 0.27% | 0% |
| Clostridium perfringens | 1.25% | 0% | 0.49% | 0% |
| Clostridium sporogenes | 8.33% | 0% | 0.85% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.04% | 0% |
| Enterococcus avium | 66.67% | 0% | 57.89% | 100% |
| Enterococcus casseliflavus | 0% | 0% | 0% | 100% |
| Enterococcus faecalis | 36.36% | 14.29% | 29.38% | 37.5% |
| Enterococcus faecium | 50% | 4.79% | 37.16% | 45.1% |
| Enterococcus hirae | 7.69% | 23.81% | 16.67% | 0% |
| Erysipelatoclostridium ramosum | 20% | 0% | 23.26% | 0% |
| Erysipelothrix rhusiopathiae | 27.27% | 0% | 0% | 66.67% |
| Escherichia albertii | 0% | 0% | 0.65% | 0% |
| Escherichia coli | 0.1% | 0.75% | 1.9% | 0% |
| Escherichia fergusonii | 1.64% | 0.71% | 4.35% | 0% |
| Eubacterium maltosivorans | 0% | 0% | 33.33% | 0% |
| Fusobacterium necrophorum | 0% | 0% | 6.98% | 0% |
| Fusobacterium nucleatum | 8.33% | 0% | 8.82% | 0% |
| Gardnerella vaginalis | 26.67% | 0% | 16.5% | 100% |
| Gemella haemolysans | 0% | 0% | 25% | 0% |
| Gemella morbillorum | 33.33% | 0% | 25% | 0% |
| Haemophilus parainfluenzae | 0% | 0% | 2.44% | 0% |
| Histophilus somni | 0% | 0% | 3.45% | 0% |
| Jeotgalibaca ciconiae | 100% | 0% | 0% | 100% |
| Jeotgalibaca porci | 100% | 0% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0.06% | 0.09% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.26% | 0% |
| Lactobacillus gasseri | 0% | 0% | 1.92% | 0% |
| Lactobacillus iners | 71.43% | 0% | 12.9% | 100% |
| Lactococcus garvieae | 0% | 4.17% | 4.44% | 0% |
| Ligilactobacillus animalis | 0% | 0% | 25% | 0% |
| Listeria innocua | 17.65% | 0% | 6.77% | 100% |
| Listeria monocytogenes | 1.4% | 0% | 1.54% | 100% |
| Megasphaera stantonii | 0% | 0% | 25% | 0% |
| Mycoplasma mycoides | 40% | 0% | 0% | 89.47% |
| Neisseria gonorrhoeae | 0% | 8.67% | 6.33% | 0% |
| Neisseria meningitidis | 0% | 0% | 0.09% | 0% |
| Neisseria sicca | 33.33% | 0% | 0% | 0% |
| Parvimonas micra | 30% | 0% | 6.25% | 100% |
| Peptoniphilus harei | 100% | 0% | 71.43% | 100% |
| Proteus mirabilis | 0% | 0% | 0.33% | 0% |
| Providencia rettgeri | 0% | 0% | 2.55% | 0% |
| Salmonella enterica | 0.25% | 1.64% | 0.43% | 0.66% |
| Shigella boydii | 0% | 0% | 3.33% | 0% |
| Shigella flexneri | 0% | 2.01% | 0% | 0% |
| Shigella sonnei | 0% | 0% | 0.73% | 0% |
| Staphylococcus aureus | 12.13% | 0.19% | 6.4% | 7.16% |
| Staphylococcus capitis | 10% | 0% | 3.16% | 0% |
| Staphylococcus epidermidis | 0% | 0% | 0.59% | 0% |
| Staphylococcus haemolyticus | 6.9% | 0% | 2.2% | 0% |
| Staphylococcus hominis | 0% | 0% | 0.98% | 0% |
| Staphylococcus pseudintermedius | 40% | 0% | 37.69% | 13.33% |
| Staphylococcus saprophyticus | 0% | 0% | 0.7% | 0% |
| Staphylococcus simulans | 0% | 0% | 3.39% | 0% |
| Streptococcus agalactiae | 53.27% | 0% | 46.2% | 66.67% |
| Streptococcus anginosus | 35.29% | 0% | 18.71% | 0% |
| Streptococcus canis | 33.33% | 0% | 13.33% | 100% |
| Streptococcus constellatus | 37.5% | 0% | 40.91% | 0% |
| Streptococcus cristatus | 75% | 0% | 31.43% | 100% |
| Streptococcus dysgalactiae | 4% | 0% | 15.89% | 0% |
| Streptococcus equi | 0% | 0% | 0.68% | 0% |
| Streptococcus equinus | 0% | 0% | 0% | 66.67% |
| Streptococcus gallolyticus | 50% | 0% | 27.27% | 0% |
| Streptococcus gordonii | 14.29% | 0% | 23.08% | 0% |
| Streptococcus gwangjuense | 100% | 0% | 0% | 100% |
| Streptococcus iniae | 0% | 0% | 1.16% | 0% |
| Streptococcus intermedius | 14.29% | 0% | 22.73% | 0% |
| Streptococcus lutetiensis | 28.57% | 0% | 24.49% | 100% |
| Streptococcus mitis | 44.44% | 0% | 14.14% | 0% |
| Streptococcus mutans | 0% | 0% | 0.39% | 0% |
| Streptococcus pasteurianus | 50% | 0% | 65% | 33.33% |
| Streptococcus pneumoniae | 33.98% | 0% | 35.7% | 12.5% |
| Streptococcus porcinus | 16.67% | 0% | 66.67% | 100% |
| Streptococcus pseudopneumoniae | 100% | 0% | 36.44% | 0% |
| Streptococcus pseudoporcinus | 33.33% | 0% | 28.57% | 100% |
| Streptococcus pyogenes | 14.55% | 0% | 4.79% | 81.82% |
| Streptococcus sanguinis | 0% | 0% | 16.49% | 0% |
| Streptococcus suis | 14.4% | 0% | 24.66% | 16.67% |
| Streptococcus uberis | 0% | 0% | 3.57% | 0% |
| Vibrio alginolyticus | 0% | 0% | 0.79% | 0% |
| Vibrio cholerae | 0% | 0% | 0.19% | 0% |
| Vibrio harveyi | 0% | 14.29% | 0% | 0% |
| Vibrio parahaemolyticus | 0% | 0.31% | 0.1% | 0% |
| Vibrio vulnificus | 0% | 0% | 0.41% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300