Streptomyces lividans otr(A)

Accession ARO:3007127
Synonym(s)tet
CARD Short Nameotr(A)S.liv
DefinitionStreptomyces lividans otr(A) is an oxytetracycline resistance ribosomal protection protein found in Streptomyces lividans.
AMR Gene Familytetracycline-resistant ribosomal protection protein
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Sequence VariantsNocardia terpenicag+wgs
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ tetracycline-resistant ribosomal protection protein [AMR Gene Family]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
Publications

Dittrich W, et al. 1992. Antimicrob Agents Chemother 36(5):1119-24 The unstable tetracycline resistance gene of Streptomyces lividans 1326 encodes a putative protein with similarities to translational elongation factors and Tet(M) and Tet(O) proteins. (PMID 1510403)

Resistomes

Prevalence of Streptomyces lividans otr(A) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Nocardia terpenica100%0%85.71%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 450


>gb|AAA26830.1|+|Streptomyces lividans otr(A) [Streptomyces lividans 1326]
MRTLNIGILAHVDAGKTSLTERLLFDHGAVDRLGSVDAGDTRTVDGGIERRRGITIRSAVAAFTVGDTRVNLIDTPGHSDFVAEVERALE
VLDGAVLLLSAVEGVQARTRVLMRALRRLRLPTIVFVNKIDRAGARTDGLLGDVRRLLTPHVAPLTEVADAGTPRARVTRRPPDGRTAEA
LAEVDTEVLAALVDGPEPTGEDVARALAARTADGSFHPLYHGSALGGQGVAELVEGLLGLIPAATPGTSGGTSGGTEPRGTVFAVRPGPA
GERTAYLRLYGGEVHPRRRLTFLRRESDGRTTEVSGRVTRLDVVGGDATLTAGNIAALTVPGGLRVGDRLGGPTDRAPQFAPPTLQTLVR
ARHPEQAAPLRSALLALADQDPLLHARPAASGATALLLYGEVQMEVLAATLAEDFGIEAEFTPGRVRFLERPAGTDEAAEEMPWLDRTRY
FATIGLRVEPGPRGSGGAFGYETELGALPRAFHQAVEETVHDTLRTGLTGAAVTDYRVTLIRSGFSSPLSTAADFRGLTPLVLRRALARA
GTVLHEPYQAFEAEVPADTLAAVTALLASLGADFTGTTGGDPAWIVTGELPARRVREAELRLPGLTHGEAVWSSRPCEDRPLKAGNSGPG
TGVGGHSGE


>gb|M74049.1|+|343-2262|Streptomyces lividans otr(A) [Streptomyces lividans 1326]
ATGCGCACCCTGAACATCGGCATTCTGGCCCACGTCGACGCGGGTAAGACCAGCCTGACCGAACGGCTCCTGTTCGACCACGGCGCCGTC
GACCGGCTCGGCAGCGTCGACGCCGGCGACACCCGTACGGTCGACGGCGGTATCGAGCGCCGCCGCGGCATCACCATCCGCTCCGCCGTC
GCCGCCTTCACCGTCGGCGACACGCGCGTCAACCTGATCGACACCCCGGGACACTCCGACTTCGTCGCGGAGGTCGAGCGGGCCCTGGAA
GTGCTCGACGGGGCGGTGCTGCTGCTGTCCGCCGTCGAGGGCGTCCAGGCGCGGACCCGCGTCCTGATGCGCGCGCTGCGGCGGCTGCGG
CTGCCCACGATCGTGTTCGTCAACAAGATCGACCGGGCCGGCGCGCGCACCGACGGCCTCCTCGGTGACGTCCGGCGCCTGCTGACGCCG
CACGTCGCGCCGCTGACCGAGGTGGCGGACGCCGGTACCCCGCGCGCCCGGGTCACCCGCCGCCCGCCGGACGGGCGGACCGCGGAGGCC
CTCGCCGAGGTCGACACGGAGGTCCTGGCCGCGCTGGTCGACGGCCCCGAGCCGACCGGGGAGGACGTGGCCCGCGCCCTCGCCGCCCGT
ACCGCCGACGGCTCGTTCCACCCGCTGTACCACGGCTCCGCGCTCGGCGGACAGGGCGTCGCGGAGCTGGTCGAGGGCCTGCTCGGCCTG
ATCCCGGCCGCCACGCCGGGCACGTCCGGCGGCACGTCCGGCGGCACGGAACCGCGCGGCACGGTCTTCGCCGTGCGCCCCGGACCCGCC
GGCGAGCGCACCGCGTACCTCAGGCTGTACGGCGGCGAGGTGCACCCGCGCCGGCGGCTCACCTTCCTGCGGCGCGAGTCCGACGGGCGG
ACCACCGAGGTCTCCGGCCGGGTGACCCGCCTCGACGTCGTCGGCGGCGACGCCACGCTCACCGCCGGGAACATCGCCGCGCTCACCGTT
CCCGGGGGCCTGCGCGTCGGCGACCGGCTCGGCGGACCGACCGACCGTGCACCGCAGTTCGCGCCACCGACCCTGCAGACGCTGGTCCGG
GCCCGGCACCCGGAGCAGGCGGCGCCGCTGCGCTCCGCCCTGCTGGCGCTGGCCGACCAGGACCCGCTGCTGCACGCCCGACCGGCGGCG
TCCGGCGCCACCGCCCTGCTCCTGTACGGCGAGGTCCAGATGGAGGTGCTCGCGGCGACACTGGCCGAGGACTTCGGGATCGAGGCGGAG
TTCACGCCGGGCCGCGTCCGGTTCCTGGAGCGTCCGGCGGGCACCGACGAGGCCGCGGAGGAGATGCCGTGGCTCGACCGCACCCGGTAC
TTCGCGACGATCGGGCTGCGCGTCGAACCGGGTCCGCGCGGCTCCGGCGGGGCCTTCGGGTACGAGACGGAGCTCGGCGCGCTCCCCCGG
GCCTTCCACCAGGCCGTCGAGGAGACCGTCCACGACACGCTGCGGACCGGGCTCACCGGTGCGGCGGTCACCGACTACCGGGTCACGCTG
ATCCGCTCCGGCTTCAGCTCGCCGCTCAGCACGGCCGCCGACTTCCGCGGGCTGACACCGCTCGTGCTGCGCCGTGCCCTCGCCCGCGCG
GGGACCGTGCTCCACGAGCCGTACCAGGCCTTCGAGGCGGAGGTCCCGGCGGACACGCTGGCCGCCGTGACGGCCCTGCTGGCCTCGCTG
GGCGCGGACTTCACCGGAACGACGGGGGGCGACCCGGCCTGGATCGTCACCGGCGAGCTGCCGGCCCGGCGGGTGCGGGAGGCCGAGCTG
CGGCTGCCGGGGCTGACGCACGGGGAGGCGGTCTGGTCCTCCCGCCCTTGCGAGGACCGACCGCTGAAGGCCGGAAACTCTGGGCCTGGC
ACGGGAGTTGGCGGGCATTCGGGTGAGTAG

Curator Acknowledgements