Accession ARO:3004034
DefinitiontetAB(60) is an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli. Both tetA(60) and tetB(60) are required for resistance.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump
Drug Classacridine dye, peptide antibiotic, cephalosporin, tetracycline antibiotic, macrolide antibiotic, pleuromutilin antibiotic, rifamycin antibiotic, fluoroquinolone antibiotic, nitroimidazole antibiotic, penam
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification18 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family]
2 ontology terms | Show
+ tetA(60) part_of
+ tetB(60) part_of

Reynolds LJ, et al. 2016. Front Microbiol 7:1923 Efflux in the Oral Metagenome: The Discovery of a Novel Tetracycline and Tigecycline ABC Transporter. (PMID 27999567)