Accession ARO:3004034
DefinitiontetAB(60) is an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli. Both tetA(60) and tetB(60) are required for resistance.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
2 ontology terms | Show
+ tetA(60) part_of
+ tetB(60) part_of

Reynolds LJ, et al. 2016. Front Microbiol 7:1923 Efflux in the Oral Metagenome: The Discovery of a Novel Tetracycline and Tigecycline ABC Transporter. (PMID 27999567)