tetB(60)

Accession ARO:3004036
DefinitiontetB(60) is a subunit of tetAB(60), an ABC transporter that confers resistance to tetracycline and tigercycline identified by screening a human saliva metagenomic library in Escherichia coli, which is required for resistance.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump
Drug Classnitroimidazole antibiotic, rifamycin antibiotic, peptide antibiotic, pleuromutilin antibiotic, acridine dye, penam, tetracycline antibiotic, cephalosporin, fluoroquinolone antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification20 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Reynolds LJ, et al. 2016. Front Microbiol 7:1923 Efflux in the Oral Metagenome: The Discovery of a Novel Tetracycline and Tigecycline ABC Transporter. (PMID 27999567)

Resistomes

Prevalence of tetB(60) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1100


>gb|ANZ79241.1|+|tetB(60) [uncultured bacterium]
MRTMKRLLSYLRYEKKGVLIGLFCLLLSTGATLTGPLVAKHIIDNVITPMGQAHDFKAGGLLLWVGIYVTVNLVGVAGAYLNRVYMKTLS
NRIAKRIRDEVFEHVQTLPVSYFDHLPAGKVVSRITSDTESVRANFYVSGISTLFSTIVMLVGVYITIFLLNATLGLVLLFLVPVMILWQ
RTVATKQKKYYSENRELYSQLSGQLNESIQGAGIVQAFQQEEKIVAEYDATATSWVEVGRKELILESYFSWSLVGMLRNITHFGVIYYFS
MQFIGGTLGISAGLLYAFIDYINRIYEPIQTFMNVVSGFQQSMAAGDRVFELMDTPSEESGEELFTFDEGCIEFKDVSFEYTAGVPVLKH
LNFTVEPGQTVAFVGHTGSGKSSIMNLLFRFYDPTSGAIFIDGKNTRDFNRRSVRSEMGIVLQDPYLFTGTIASNVGLNNESIEPETIKE
AIIKVGGGHLLTKSDKGLDYEVKEKGMDFSSGERQLISFARAIVFDPKILILDEATSHIDTETEEIIQNAINVVKEGRTTFMIAHRLSTI
AHADQIFVLDKGEIVERGTHDELLQLQGQYAEMVALQKG


>gb|KX000273.1|+|1-1740|tetB(60) [uncultured bacterium]
ATGAGAACGATGAAGCGATTATTAAGCTACCTCCGTTATGAGAAAAAAGGAGTTCTGATTGGACTCTTCTGCCTGTTACTCTCAACAGGA
GCAACCTTAACAGGGCCACTCGTTGCGAAACACATTATCGATAATGTGATTACTCCGATGGGGCAGGCGCATGATTTCAAAGCAGGTGGC
CTACTTTTATGGGTTGGTATTTACGTGACAGTGAACTTAGTGGGAGTTGCTGGGGCCTATTTAAACCGTGTATATATGAAGACTCTCTCA
AACCGTATTGCAAAACGCATTCGTGACGAAGTGTTCGAGCATGTACAAACCTTGCCGGTATCGTACTTCGACCATTTACCAGCTGGGAAA
GTGGTTTCTAGAATTACAAGTGATACAGAATCAGTGCGTGCAAACTTCTACGTGAGTGGGATTTCGACGCTTTTCAGTACGATTGTGATG
TTGGTAGGTGTTTATATAACCATTTTCTTATTAAACGCAACGCTAGGACTCGTATTATTATTCCTAGTTCCTGTGATGATTCTATGGCAG
AGAACCGTTGCTACGAAGCAGAAAAAATACTATTCCGAAAATCGTGAACTCTATAGTCAGTTGAGTGGACAATTAAACGAAAGCATTCAA
GGAGCAGGCATCGTTCAAGCCTTCCAGCAAGAAGAAAAAATTGTTGCAGAATATGATGCCACGGCAACTTCTTGGGTAGAAGTTGGTCGT
AAGGAATTAATTCTTGAGTCGTACTTCTCGTGGAGTCTTGTCGGCATGCTTCGAAACATTACTCATTTTGGAGTTATCTATTATTTCAGT
ATGCAGTTTATCGGTGGAACACTCGGGATTTCAGCAGGTCTTTTATATGCATTTATTGACTACATTAATCGTATATATGAGCCGATTCAA
ACTTTTATGAATGTCGTGTCTGGCTTCCAGCAATCAATGGCTGCTGGTGACCGTGTGTTTGAACTAATGGATACACCGAGCGAGGAATCG
GGAGAAGAGCTCTTCACGTTTGATGAAGGATGTATCGAATTTAAAGATGTGAGTTTTGAGTACACAGCGGGAGTTCCTGTGTTGAAACAC
TTGAATTTCACGGTAGAACCAGGACAGACGGTTGCTTTTGTCGGACATACTGGTTCAGGGAAATCATCCATTATGAACTTACTGTTTCGC
TTCTACGACCCAACGAGTGGTGCTATCTTCATCGATGGCAAAAACACACGCGACTTTAACAGACGTAGTGTTCGAAGCGAGATGGGAATC
GTTCTTCAAGATCCGTACCTCTTTACAGGAACGATTGCTTCAAACGTAGGGCTCAACAATGAATCGATTGAGCCTGAGACGATAAAAGAG
GCGATTATTAAAGTGGGTGGAGGACATCTACTTACGAAGAGTGACAAGGGCTTGGACTACGAGGTGAAAGAAAAAGGAATGGATTTCTCT
TCAGGAGAACGCCAACTGATTTCATTTGCTCGTGCGATCGTCTTTGACCCGAAAATCTTAATTTTAGACGAGGCAACTTCGCATATCGAT
ACCGAGACAGAAGAGATTATTCAGAATGCAATTAATGTCGTCAAAGAAGGGCGTACAACCTTTATGATTGCTCACCGACTTTCCACAATT
GCTCATGCTGACCAAATTTTTGTGTTGGATAAAGGAGAAATTGTAGAACGTGGAACGCATGATGAATTGCTTCAACTGCAAGGTCAATAT
GCCGAAATGGTCGCCCTACAAAAAGGATAA