tet(44)

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Accession ARO:3000556
CARD Short Nametet(44)
DefinitionTet44 is a tetracycline resistance gene found in Campylobacter fetus, and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein.
AMR Gene Familytetracycline-resistant ribosomal protection protein
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Sequence VariantsCampylobacter fetusg, Clostridium perfringensg+wgs+gi, Erysipelatoclostridium ramosumwgs, Streptococcus agalactiaewgs, Streptococcus suiswgs
Classification7 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ tetracycline-resistant ribosomal protection protein [AMR Gene Family]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic doxycycline [Antibiotic]
+ confers_resistance_to_antibiotic minocycline [Antibiotic]
+ confers_resistance_to_antibiotic chlortetracycline [Antibiotic]
+ confers_resistance_to_antibiotic demeclocycline [Antibiotic]
+ confers_resistance_to_antibiotic oxytetracycline [Antibiotic]
Publications

Abril C, et al. 2010. Antimicrob Agents Chemother 54(7): 3052-3055. Two novel antibiotic resistance genes, tet(44) and ant(6)-Ib, are located within a transferable pathogenicity island in Campylobacter fetus subsp. fetus. (PMID 20479200)
Resistomes

Prevalence of tet(44) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Campylobacter fetus4.35%0%0%0%0%
Clostridium perfringens3.75%0%8.8%50%0%
Erysipelatoclostridium ramosum0%0%11.63%0%0%
Streptococcus agalactiae0%0%0.06%0%0%
Streptococcus suis0%0%0.58%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 300


>gb|CBH51823.1|+|tet(44) [Campylobacter fetus subsp. fetus]
MKIINIGILAHVDAGKTTLTESLLYTSGAILELGSVDKGTTRTDTMFLERQRGITIQAAVTSFNWNDYKINIVDTPGHTDFITEVYRSLS
VLDGAILVISAKDGVQAQTRILFHALQKMNIPTIIFINKIDQDGINLNNIYQNIKEKLSNDIIVMQNVTLTPEISIKNIIDLDDWDPVIS
KNDKLLEKYIVGEKLTIQELMYEEYRCVKKGSLFPIYHGSARNNIGTQQLIEAISNLFCSEMNENDSELCGRVFKIEYTDHKQRLVYLRL
YSGTLHLRDTIILPEKKKVKLTEIYIPSNGEMIQTKTVCSGDIFIIPNNTLRLNDIIGNEKLLPCNVWNDKTVPILRTRIEPIKIEEREK
LLDALTEIADTDPLLRYYVDTITHEIIISFLGTVQLEVICSLLIEKYHINIRIEDPTVIYLEKPLQKADYTIHIEVPPNPFWASIGLSIT
PLPIGSGIQYESKVSLGYLNQSFQNAVREGINYGLEQGLYGWEVTDCKICFEYGVYYSPVSTPSDFRFLAPIVLEQTLKKAGTQLLEPYL
SFILFTPQGYFSRAYKDAQKHCAIIETSQSKNDEVIFTGHIPVRCINEYRNTLTLYTNGQAVFLTELKDYQIATCEPVIQSRRPNNRIDK
VRHMFNKKEN


>gb|FN594949.1|+|25245-27167|tet(44) [Campylobacter fetus subsp. fetus]
ATGAAAATAATCAACATTGGTATTCTTGCTCATGTAGATGCAGGAAAGACGACCTTAACGGAAAGTCTGCTTTATACAAGTGGAGCAATT
TTAGAATTAGGCAGTGTAGATAAGGGAACAACAAGGACAGATACTATGTTTTTAGAACGTCAGCGTGGAATCACAATTCAGGCAGCAGTT
ACTTCTTTTAATTGGAATGACTACAAAATCAATATTGTAGATACTCCTGGACATACAGATTTTATAACAGAAGTGTATCGTTCCTTATCT
GTTCTTGATGGAGCAATTTTAGTAATTTCTGCTAAAGATGGTGTACAAGCACAAACCCGAATACTATTCCATGCACTTCAAAAAATGAAT
ATACCAACAATTATTTTTATAAATAAAATAGATCAGGATGGAATTAACTTAAATAATATTTATCAAAATATCAAAGAAAAACTTTCAAAT
GATATTATTGTTATGCAAAATGTAACATTAACTCCAGAAATATCAATTAAAAATATCATTGATTTAGATGATTGGGATCCTGTAATTTCC
AAAAATGATAAACTTTTAGAAAAATATATTGTAGGAGAAAAATTGACTATACAAGAATTAATGTATGAAGAATATAGGTGTGTTAAAAAA
GGTTCGTTGTTTCCTATATACCATGGAAGTGCTAGAAATAATATAGGGACTCAACAACTTATCGAAGCTATTTCAAATCTTTTTTGTTCT
GAAATGAATGAGAATGATTCAGAACTATGTGGAAGAGTTTTTAAAATTGAATATACAGACCATAAGCAAAGATTAGTTTATTTGCGTCTT
TATAGTGGAACATTACACTTACGAGATACAATTATATTGCCAGAAAAAAAGAAAGTGAAACTTACAGAAATATATATTCCTTCAAATGGA
GAAATGATACAGACAAAAACAGTTTGTTCTGGAGATATTTTTATTATACCTAACAATACATTAAGATTGAACGATATTATAGGAAATGAA
AAGCTTTTGCCATGCAATGTATGGAATGACAAGACTGTACCAATACTACGAACAAGAATTGAACCGATAAAAATAGAAGAGAGAGAAAAA
TTATTGGATGCTCTTACAGAAATTGCAGATACTGATCCTCTTTTACGTTATTATGTTGATACGATAACACATGAAATCATCATTTCTTTT
TTAGGAACAGTGCAGTTAGAAGTTATCTGTTCTCTGTTGATTGAAAAATATCACATAAACATAAGAATCGAAGATCCAACCGTAATTTAT
TTGGAAAAACCATTACAAAAGGCAGATTATACTATTCATATTGAAGTACCACCAAATCCATTTTGGGCATCGATTGGATTATCAATAACT
CCACTTCCAATTGGCAGTGGAATACAGTACGAAAGCAAAGTTTCACTCGGTTATTTAAATCAAAGTTTCCAAAATGCAGTAAGAGAAGGT
ATTAATTATGGACTGGAGCAAGGTTTGTATGGTTGGGAAGTAACAGATTGTAAAATATGTTTTGAATATGGTGTTTATTATAGCCCTGTT
AGTACTCCCTCGGATTTTCGCTTTCTTGCCCCAATTGTACTTGAACAAACATTGAAAAAAGCGGGAACGCAATTATTAGAGCCATATCTT
TCGTTTATACTTTTTACGCCACAGGGATACTTTTCTCGTGCATATAAAGATGCACAAAAACATTGTGCAATAATTGAAACAAGTCAATCA
AAAAATGATGAAGTTATTTTTACAGGACATATTCCTGTACGTTGTATTAATGAATATCGTAATACTTTAACTCTATATACAAATGGGCAA
GCAGTTTTTTTGACAGAATTAAAAGATTATCAAATTGCTACTTGTGAACCAGTTATTCAATCACGTAGACCAAATAATCGAATAGATAAA
GTACGCCATATGTTTAATAAAAAAGAAAATTAA

Curator Acknowledgements
Curator Description Most Recent Edit