| Accession | ARO:3000556 |
| CARD Short Name | tet(44) |
| Definition | Tet44 is a tetracycline resistance gene found in Campylobacter fetus, and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein. |
| AMR Gene Family | tetracycline-resistant ribosomal protection protein |
| Drug Class | tetracycline antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Sequence Variants | Campylobacter fetusg, Clostridium perfringensg+wgs+gi, Erysipelatoclostridium ramosumwgs, Streptococcus agalactiaewgs, Streptococcus suiswgs |
| Classification | 7 ontology terms | Show |
| Parent Term(s) | 7 ontology terms | Show + tetracycline-resistant ribosomal protection protein [AMR Gene Family] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic doxycycline [Antibiotic] + confers_resistance_to_antibiotic minocycline [Antibiotic] + confers_resistance_to_antibiotic chlortetracycline [Antibiotic] + confers_resistance_to_antibiotic demeclocycline [Antibiotic] + confers_resistance_to_antibiotic oxytetracycline [Antibiotic] |
| Publications | Abril C, et al. 2010. Antimicrob Agents Chemother 54(7): 3052-3055. Two novel antibiotic resistance genes, tet(44) and ant(6)-Ib, are located within a transferable pathogenicity island in Campylobacter fetus subsp. fetus. (PMID 20479200) |
Prevalence of tet(44) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Campylobacter fetus | 4.35% | 0% | 0% | 0% |
| Clostridium perfringens | 3.75% | 0% | 2.44% | 50% |
| Erysipelatoclostridium ramosum | 0% | 0% | 8.14% | 0% |
| Streptococcus agalactiae | 0% | 0% | 0.06% | 0% |
| Streptococcus suis | 0% | 0% | 0.58% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300