tet(52)

Accession ARO:3004587
CARD Short Nametet(52)
DefinitionA tetracycline inactivating enzyme. A flavoenzyme capable of degrading tetracycline antibiotics.
AMR Gene Familytetracycline inactivation enzyme
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ tetracycline inactivation enzyme [AMR Gene Family]
+ confers_resistance_to_antibiotic oxytetracycline [Antibiotic]
Publications

Forsberg KJ, et al. 2015. Chem. Biol. 22(7):888-97 The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes. (PMID 26097034)

Resistomes

Prevalence of tet(52) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 750


>gb|AKQ05896.1|+|tet(52) [uncultured bacterium]
MSNVNKILVIGAGIAGPAACYWLRRFGFSPVLVERSASLRKGGHALDVRGVAIDLVKRMGIYQKIYNMRTQLEFGRHVDPEGNTLHEEKG
ERFGFREGQDVEIIRSDLVEILIDSIEGVPLQFNQTIESVKQTDAVVEVQFKDGRTEHFDLVIGADGLHSTTRRIVFDKHEYKLNDLGAY
FSVFSIPNYLNLNNTEVQCEANQKLLSITSDKNRKMAEVAFSFRGQNVLNNVRDESEQRRVLRDTFQDFGWEAPRILELMSDSDDFYSDS
FTQVIMKSWTKGRVALLGDAAYSASPISGQGNNLALVGAYVLAGELKQAGGNYKRAFDRYNEILRPFIEANQKLGVLVNESFLVRDEVSK
EVAEERSNNIMEQVKIASNMIVLQDYANPH


>gb|KR857686.1|+|1-1173|tet(52) [uncultured bacterium]
ATGTCTAATGTGAATAAAATTCTCGTCATCGGGGCTGGCATTGCTGGCCCCGCGGCTTGTTATTGGTTAAGAAGATTCGGATTTTCTCCC
GTCCTCGTAGAAAGATCTGCCAGTTTACGAAAAGGCGGTCATGCACTGGACGTTCGAGGTGTTGCAATAGACCTCGTCAAAAGAATGGGT
ATTTATCAGAAAATATATAATATGCGCACTCAGCTGGAGTTTGGGCGGCATGTTGACCCCGAAGGGAATACGCTTCATGAAGAGAAGGGC
GAAAGATTTGGCTTTAGGGAAGGTCAAGATGTTGAAATTATCCGCAGTGATTTGGTCGAGATATTGATAGATTCCATTGAAGGCGTCCCC
CTTCAGTTCAATCAAACGATTGAGAGCGTTAAACAGACTGATGCTGTTGTCGAAGTTCAATTTAAAGATGGCAGAACCGAACACTTCGAT
TTGGTTATCGGGGCTGACGGCTTGCACTCAACAACAAGACGTATCGTATTTGATAAACATGAATATAAATTAAATGACCTTGGTGCTTAC
TTTAGTGTTTTCAGTATTCCAAATTATCTAAATTTGAATAACACCGAAGTTCAGTGCGAAGCTAATCAAAAACTGTTATCTATAACGAGC
GACAAGAACCGCAAGATGGCTGAGGTCGCATTCTCATTTCGTGGCCAGAATGTTTTGAATAATGTTCGTGATGAAAGCGAGCAACGGCGA
GTCCTACGCGACACTTTTCAAGACTTTGGCTGGGAAGCACCAAGAATACTTGAACTGATGTCAGATAGTGATGATTTTTATTCTGATTCA
TTCACTCAGGTAATAATGAAATCATGGACTAAAGGTCGAGTTGCATTATTGGGAGATGCTGCGTACAGCGCGTCGCCAATATCGGGGCAA
GGTAATAATCTGGCCCTGGTCGGCGCTTATGTTTTGGCAGGAGAACTAAAACAGGCAGGCGGCAATTATAAGCGGGCATTTGATCGTTAT
AATGAAATATTACGTCCATTTATTGAAGCTAATCAAAAATTGGGAGTCTTGGTTAACGAATCGTTTCTTGTTCGCGATGAAGTCTCTAAA
GAGGTTGCGGAAGAACGGTCAAATAATATTATGGAACAGGTAAAAATCGCATCGAACATGATTGTGTTGCAGGATTACGCCAATCCGCAC
TGA