tetracycline inactivation enzyme [AMR Gene Family]

Accession ARO:3000036
DefinitionEnzymes or other gene products which hydroxylate tetracycline and other tetracycline derivatives. Hydroxylation inactivates tetracycline-like antibiotics, thus conferring resistance to these compounds.
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic inactivation
Classification5 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ antibiotic inactivation enzyme
+ confers_resistance_to_drug_class tetracycline antibiotic [Drug Class]
+ participates_in hydroxylation of antibiotic conferring resistance
18 ontology terms | Show

Nguyen F, et al. 2014. Biol Chem 395(5): 559-575. Tetracycline antibiotics and resistance mechanisms. (PMID 24497223)