tet(50)

Accession ARO:3004584
DefinitionA tetracycline-resistant ribosomal protection protein. A flavoenzyme capable of degrading tetracycline antibiotics.
AMR Gene Familytetracycline-resistant ribosomal protection protein
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic target protection
Classification8 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Publications

Forsberg KJ, et al. 2015. Chem. Biol. 22(7):888-97 The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes. (PMID 26097034)

Resistomes

Prevalence of tet(50) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 750


>gb|AKQ05894.1|+|tet(50) [uncultured bacterium]
MTKHIKILVIGVGVAGPAVAYWLKRFGFSPVLIEKSAAVRKGGQALDIRGIATHIAKEMGIYDQICNMRTQIKCGRYVDVKGNVLHEEQG
ETFGFRQDDEVEILRGDLVEILMKAIADIPCEFKQSVIKIEQNEDSVTVTYKDGRVENYDLVIAADGIHSATRGMVFSKNEYQLINLGSY
VSAFTIPNYLGLDHMELLCESNHKLVTLQSDSQADKAMAGFMFRSKHVLEDIRDEQEQKHFLHASFQNFGWETQNILNRMPESDDFYFDA
ITQIKMKSWTKGRIALIGDAAYCPSPLSGQGNNLAFVGAYILAGELKKADGDYIQAFTRYNELLHPFVEANQQFGVWVSESFLLKDDEVS
KEIAEARSNKILAMIKSVSNSINLPQYE


>gb|KR857684.1|+|1-1167|tet(50) [uncultured bacterium]
ATGACTAAACATATAAAAATTCTTGTAATAGGGGTTGGGGTTGCGGGCCCTGCAGTCGCTTATTGGTTAAAAAGATTTGGGTTTTCTCCG
GTCTTAATTGAAAAATCAGCTGCCGTTAGAAAAGGGGGCCAGGCACTTGATATTCGCGGCATAGCCACACATATCGCTAAAGAAATGGGC
ATTTACGACCAGATATGTAACATGCGGACTCAAATAAAGTGTGGACGTTATGTGGATGTAAAGGGTAATGTTTTGCATGAAGAACAAGGT
GAAACCTTTGGTTTCCGGCAAGATGACGAAGTTGAGATTCTTCGTGGAGACCTAGTTGAAATTCTAATGAAAGCAATTGCAGATATACCT
TGTGAATTCAAACAATCCGTCATAAAAATTGAACAAAACGAAGATAGTGTAACTGTCACCTACAAAGATGGCAGAGTTGAAAATTATGAC
CTTGTGATCGCTGCCGATGGTATTCATTCTGCTACCAGGGGAATGGTTTTTAGTAAAAATGAATATCAGTTGATTAATCTCGGCTCCTAC
GTCAGCGCATTTACCATCCCAAATTATCTCGGTTTGGATCACATGGAACTCCTATGTGAATCAAATCATAAACTGGTTACTCTACAAAGC
GACAGCCAAGCTGACAAAGCCATGGCGGGATTTATGTTCCGTTCAAAACATGTATTAGAAGATATTCGTGATGAGCAAGAACAAAAACAT
TTCTTACACGCCAGTTTTCAAAATTTCGGTTGGGAAACACAAAATATTTTAAATCGAATGCCAGAAAGCGATGACTTTTATTTTGACGCG
ATTACTCAAATCAAAATGAAAAGCTGGACTAAAGGCCGTATAGCCTTAATCGGCGATGCCGCTTATTGCCCCTCACCTTTATCAGGTCAG
GGGAATAATTTAGCTTTTGTTGGCGCTTATATTTTGGCGGGTGAATTGAAAAAGGCTGATGGTGATTATATACAAGCATTTACCCGATAT
AACGAATTGCTACATCCCTTTGTTGAGGCTAACCAACAATTTGGTGTGTGGGTAAGCGAATCCTTTCTCCTAAAAGATGATGAAGTCTCT
AAAGAGATTGCGGAAGCCCGTTCTAATAAAATTTTGGCAATGATAAAGTCAGTCTCTAATTCAATAAACTTGCCACAATACGAATAA