| Accession | ARO:3004719 |
| Synonym(s) | tetX3 |
| CARD Short Name | tet(X3) |
| Definition | A tetracyline resistance gene located on an approximately 300-kb plasmid, designated p47AB. It inactivates all tetracyclines, including tigecycline, eravacycline, and omadacycline.Adjacent to insertion sequence ISVsa3 on the conjugative plasmid. |
| AMR Gene Family | tetracycline inactivation enzyme |
| Drug Class | tetracycline antibiotic, glycylcycline |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniip+wgs, Acinetobacter indicusg+p+wgs, Acinetobacter johnsoniip+wgs, Acinetobacter juniip+wgs, Acinetobacter lwoffiiwgs, Acinetobacter nosocomialisp+wgs, Acinetobacter pittiip+wgs, Acinetobacter townerip+wgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniip+wgs, Acinetobacter indicusg+p+wgs, Acinetobacter johnsoniip+wgs, Acinetobacter juniip+wgs, Acinetobacter lwoffiiwgs, Acinetobacter nosocomialisp+wgs, Acinetobacter pittiip+wgs, Acinetobacter townerip+wgs |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + tetracycline antibiotic [Drug Class] + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydroxylation of antibiotic conferring resistance + glycylcycline [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic tigecycline [Antibiotic] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + tetracycline inactivation enzyme [AMR Gene Family] |
| Publications | He T, et al. 2019. Nat Microbiol : Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans. (PMID 31133751) |
Prevalence of tet(X3) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0.36% | 0.07% | 0% |
| Acinetobacter indicus | 4.76% | 20.75% | 2.6% | 0% |
| Acinetobacter johnsonii | 0% | 1.39% | 9.09% | 0% |
| Acinetobacter junii | 0% | 16.67% | 1.49% | 0% |
| Acinetobacter lwoffii | 0% | 0% | 2.63% | 0% |
| Acinetobacter nosocomialis | 0% | 1.64% | 1.15% | 0% |
| Acinetobacter pittii | 0% | 0.99% | 0.85% | 0% |
| Acinetobacter towneri | 0% | 18.75% | 11.54% | 0% |
| Escherichia coli | 0% | 0% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 760