| Accession | ARO:3000205 |
| Synonym(s) | tetX |
| CARD Short Name | tet(X) |
| Definition | Tet(X) is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics. Tet(X) hydroxylates position 11a of the tetraketide group thus inactivating the antibiotic. |
| AMR Gene Family | tetracycline inactivation enzyme |
| Drug Class | tetracycline antibiotic, glycylcycline |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Acinetobacter pittiig, Acinetobacter townerigi, Aeromonas caviaegi, Bacteroides caccaewgs, Bacteroides fragilisg+p+wgs, Bacteroides ovatusp+wgs, Bacteroides thetaiotaomicrong+p+wgs, Chryseobacterium taklimakanenseg, Elizabethkingia anophelisg+wgs, Myroides odoratimimusg+p+wgs+gi, Myroides phaeusg+wgs+gi, Parabacteroides distasonisg+wgs, Phocaeicola doreiwgs, Phocaeicola massiliensiswgs, Phocaeicola vulgatuswgs, Riemerella anatipestiferg+wgs+gi, Sphingobacterium hotanenseg+gi |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + tetracycline antibiotic [Drug Class] + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydroxylation of antibiotic conferring resistance + glycylcycline [Drug Class] |
| Parent Term(s) | 9 ontology terms | Show + confers_resistance_to_antibiotic tigecycline [Antibiotic] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic doxycycline [Antibiotic] + tetracycline inactivation enzyme [AMR Gene Family] + confers_resistance_to_antibiotic minocycline [Antibiotic] + participates_in hydroxylation of antibiotic conferring resistance + confers_resistance_to_antibiotic chlortetracycline [Antibiotic] + confers_resistance_to_antibiotic demeclocycline [Antibiotic] + confers_resistance_to_antibiotic oxytetracycline [Antibiotic] |
| Publications | Volkers G, et al. 2011. FEBS Lett 585(7): 1061-1066. Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase. (PMID 21402075) Moore IF, et al. 2005. Biochemistry 44(35): 11829-11835. Tigecycline is modified by the flavin-dependent monooxygenase TetX. (PMID 16128584) Yang W, et al. 2004. J Biol Chem 279(50): 52346-52352. TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics. (PMID 15452119) Speer BS, et al. 1991. J Bacteriol 173(1): 176-183. Evidence that a novel tetracycline resistance gene found on two Bacteroides transposons encodes an NADP-requiring oxidoreductase. (PMID 1846135) |
Prevalence of tet(X) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter pittii | 2.7% | 0% | 0% | 0% |
| Acinetobacter towneri | 0% | 0% | 0% | 100% |
| Aeromonas caviae | 0% | 0% | 0% | 33.33% |
| Bacteroides caccae | 0% | 0% | 5% | 0% |
| Bacteroides fragilis | 3.85% | 4.17% | 6.9% | 0% |
| Bacteroides ovatus | 0% | 2.94% | 8.37% | 0% |
| Bacteroides thetaiotaomicron | 17.86% | 2.27% | 8.04% | 0% |
| Chryseobacterium taklimakanense | 33.33% | 0% | 0% | 0% |
| Elizabethkingia anophelis | 5.77% | 0% | 6.19% | 0% |
| Myroides odoratimimus | 100% | 50% | 14.29% | 50% |
| Myroides phaeus | 100% | 0% | 100% | 50% |
| Parabacteroides distasonis | 11.54% | 0% | 2.34% | 0% |
| Phocaeicola dorei | 0% | 0% | 11.46% | 0% |
| Phocaeicola massiliensis | 0% | 0% | 19.23% | 0% |
| Phocaeicola vulgatus | 0% | 0% | 9.47% | 0% |
| Riemerella anatipestifer | 16.67% | 0% | 15.28% | 100% |
| Sphingobacterium hotanense | 100% | 0% | 0% | 100% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 750
