| Accession | ARO:3000190 |
| Synonym(s) | tetO |
| CARD Short Name | tet(O) |
| Definition | Tet(O) is a ribosomal protection protein. It is associated with conjugative plasmids. |
| AMR Gene Family | tetracycline-resistant ribosomal protection protein |
| Drug Class | tetracycline antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Perfect Matches | Campylobacter colig+p+wgs, Campylobacter fetuswgs, Campylobacter jejunip+wgs, Campylobacter upsaliensiswgs |
| Resistomes with Sequence Variants | Actinobacillus pleuropneumoniaeg, Anaerostipes hadruswgs, Bifidobacterium bifidumwgs, Bifidobacterium breveg+wgs, Bifidobacterium longumwgs, Blautia productawgs, Campylobacter colig+p+wgs, Campylobacter concisuswgs, Campylobacter fetuswgs, Campylobacter jejunig+p+wgs, Campylobacter upsaliensiswgs, Corynebacterium amycolatumwgs, Corynebacterium diphtheriaewgs, Eggerthella lentag+wgs, Enterocloster clostridioformisg+wgs, Enterococcus faecalisp+wgs, Enterococcus faeciumwgs, Enterococcus hiraewgs, Erysipelatoclostridium ramosumwgs, Eubacterium limosumwgs, Eubacterium maltosivoranswgs, Faecalibacterium prausnitziig+wgs, Fusobacterium necrophorumwgs, Gordonibacter urolithinfacienswgs, Helicobacter pullorumwgs, Mobiluncus mulieriswgs, Pasteurella multocidawgs, Roseburia hominiswgs, Ruthenibacterium lactatiformanswgs, Salmonella entericap+wgs, Staphylococcus aureuswgs, Staphylococcus pseudintermediuswgs, Streptococcus agalactiaeg+wgs, Streptococcus anginosusg+wgs, Streptococcus canisg+wgs, Streptococcus constellatuswgs, Streptococcus dysgalactiaeg+wgs, Streptococcus equiwgs, Streptococcus gallolyticuswgs, Streptococcus gordoniiwgs, Streptococcus iniaewgs, Streptococcus intermediuswgs, Streptococcus mitiswgs, Streptococcus pasteurianusg+wgs, Streptococcus pneumoniaewgs, Streptococcus porcinusg+wgs, Streptococcus pseudopneumoniaewgs, Streptococcus pyogenesg+wgs, Streptococcus sanguiniswgs, Streptococcus suisg+wgs, Streptococcus uberiswgs |
| Classification | 7 ontology terms | Show |
| Parent Term(s) | 7 ontology terms | Show + tetracycline-resistant ribosomal protection protein [AMR Gene Family] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic doxycycline [Antibiotic] + confers_resistance_to_antibiotic minocycline [Antibiotic] + confers_resistance_to_antibiotic chlortetracycline [Antibiotic] + confers_resistance_to_antibiotic demeclocycline [Antibiotic] + confers_resistance_to_antibiotic oxytetracycline [Antibiotic] |
| Publications | Luna VA and Roberts MC. 1998. J Antimicrob Chemother 42(5): 613-619. The presence of the tetO gene in a variety of tetracycline-resistant Streptococcus pneumoniae serotypes from Washington State. (PMID 9848445) LeBlanc DJ, et al. 1988. J Bacteriol 170(8): 3618-3626. Nucleotide sequence analysis of tetracycline resistance gene tetO from Streptococcus mutans DL5. (PMID 2841293) |
Prevalence of tet(O) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Actinobacillus pleuropneumoniae | 5.56% | 0% | 0% | 0% |
| Anaerostipes hadrus | 0% | 0% | 15.52% | 0% |
| Bifidobacterium bifidum | 0% | 0% | 2.99% | 0% |
| Bifidobacterium breve | 9.8% | 0% | 10.24% | 0% |
| Bifidobacterium longum | 0% | 0% | 0.21% | 0% |
| Blautia producta | 0% | 0% | 18.18% | 0% |
| Campylobacter coli | 26.09% | 20% | 26.12% | 0% |
| Campylobacter concisus | 0% | 0% | 0.45% | 0% |
| Campylobacter fetus | 0% | 0% | 1.33% | 0% |
| Campylobacter jejuni | 12.28% | 40.59% | 26.03% | 0% |
| Campylobacter upsaliensis | 0% | 0% | 3.2% | 0% |
| Corynebacterium amycolatum | 0% | 0% | 7.41% | 0% |
| Corynebacterium diphtheriae | 0% | 0% | 0.94% | 0% |
| Eggerthella lenta | 40% | 0% | 18.75% | 0% |
| Enterocloster clostridioformis | 100% | 0% | 34.88% | 0% |
| Enterococcus faecalis | 0% | 0.25% | 1.35% | 0% |
| Enterococcus faecium | 0% | 0% | 0.17% | 0% |
| Enterococcus hirae | 0% | 0% | 2.78% | 0% |
| Erysipelatoclostridium ramosum | 0% | 0% | 3.49% | 0% |
| Eubacterium limosum | 0% | 0% | 25% | 0% |
| Eubacterium maltosivorans | 0% | 0% | 33.33% | 0% |
| Faecalibacterium prausnitzii | 13.33% | 0% | 6.8% | 0% |
| Fusobacterium necrophorum | 0% | 0% | 4.65% | 0% |
| Gordonibacter urolithinfaciens | 0% | 0% | 9.09% | 0% |
| Helicobacter pullorum | 0% | 0% | 3.45% | 0% |
| Mobiluncus mulieris | 0% | 0% | 41.18% | 0% |
| Pasteurella multocida | 0% | 0% | 0.75% | 0% |
| Roseburia hominis | 0% | 0% | 44.44% | 0% |
| Ruthenibacterium lactatiformans | 0% | 0% | 6.67% | 0% |
| Salmonella enterica | 0% | 0.05% | 0.02% | 0% |
| Staphylococcus aureus | 0% | 0% | 0.04% | 0% |
| Staphylococcus pseudintermedius | 0% | 0% | 0.26% | 0% |
| Streptococcus agalactiae | 12.15% | 0% | 11.47% | 0% |
| Streptococcus anginosus | 11.76% | 0% | 8.77% | 0% |
| Streptococcus canis | 16.67% | 0% | 6.67% | 0% |
| Streptococcus constellatus | 0% | 0% | 4.55% | 0% |
| Streptococcus dysgalactiae | 6% | 0% | 6.54% | 0% |
| Streptococcus equi | 0% | 0% | 0.9% | 0% |
| Streptococcus gallolyticus | 0% | 0% | 6.82% | 0% |
| Streptococcus gordonii | 0% | 0% | 1.28% | 0% |
| Streptococcus iniae | 0% | 0% | 2.33% | 0% |
| Streptococcus intermedius | 0% | 0% | 2.27% | 0% |
| Streptococcus mitis | 0% | 0% | 0.51% | 0% |
| Streptococcus pasteurianus | 25% | 0% | 20% | 0% |
| Streptococcus pneumoniae | 0% | 0% | 0.12% | 0% |
| Streptococcus porcinus | 50% | 0% | 33.33% | 0% |
| Streptococcus pseudopneumoniae | 0% | 0% | 2.54% | 0% |
| Streptococcus pyogenes | 1.49% | 0% | 0.77% | 0% |
| Streptococcus sanguinis | 0% | 0% | 2.06% | 0% |
| Streptococcus suis | 63.2% | 0% | 42.55% | 0% |
| Streptococcus uberis | 0% | 0% | 0.89% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300