| Accession | ARO:3007122 |
| CARD Short Name | tet(O/W/32/O) |
| Definition | Tet(O/W/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein. |
| AMR Gene Family | tetracycline-resistant ribosomal protection protein |
| Drug Class | tetracycline antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Sequence Variants | Campylobacter coliwgs, Campylobacter jejuniwgs, Enterococcus faecalisg+wgs, Lactococcus garvieaep, Streptococcus agalactiaewgs, Streptococcus gallolyticusg+p+wgs, Streptococcus lutetiensiswgs, Streptococcus pasteurianusg+wgs, Streptococcus suisg+wgs |
| Classification | 7 ontology terms | Show |
| Parent Term(s) | 2 ontology terms | Show + tetracycline-resistant ribosomal protection protein [AMR Gene Family] + confers_resistance_to_antibiotic tetracycline [Antibiotic] |
| Publications | van Hoek AH, et al. 2007. Antimicrob Agents Chemother 52(1): 248-252. Mosaic tetracycline resistance genes and their flanking regions in Bifidobacterium thermophilum and Lactobacillus johnsonii. (PMID 17967912) |
Prevalence of tet(O/W/32/O) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Campylobacter coli | 0% | 0% | 0.97% | 0% |
| Campylobacter jejuni | 0% | 0% | 0.05% | 0% |
| Enterococcus faecalis | 2.27% | 0% | 0.29% | 0% |
| Lactococcus garvieae | 0% | 4.17% | 0% | 0% |
| Streptococcus agalactiae | 0% | 0% | 0.06% | 0% |
| Streptococcus gallolyticus | 10% | 50% | 6.82% | 0% |
| Streptococcus lutetiensis | 0% | 0% | 2.04% | 0% |
| Streptococcus pasteurianus | 50% | 0% | 5% | 0% |
| Streptococcus suis | 1.6% | 0% | 3.83% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 900