tet(O/W)

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Accession	ARO:3007121
CARD Short Name	tet(O/W)
Definition	Tet(O/W) is a mosaic tetracycline resistance gene and ribosomal protection protein.
AMR Gene Family	tetracycline-resistant ribosomal protection protein
Drug Class	tetracycline antibiotic
Resistance Mechanism	antibiotic target protection
Resistomes with Sequence Variants	Bifidobacterium bifidum^wgs, Bifidobacterium longum^wgs, Mobiluncus mulieris^wgs, Ruthenibacterium lactatiformans^wgs, Streptococcus equi^wgs
Classification	7 ontology terms \| Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic target protection [Resistance Mechanism] + antibiotic target protection protein + tetracycline antibiotic [Drug Class]
Parent Term(s)	2 ontology terms \| Show + tetracycline-resistant ribosomal protection protein [AMR Gene Family] + confers_resistance_to_antibiotic tetracycline [Antibiotic]
Publications	Stanton TB, et al. 2004. Appl Environ Microbiol 70(6): 3754-3757. Diverse tetracycline resistance genotypes of Megasphaera elsdenii strains selectively cultured from swine feces. (PMID 15184185)

Resistomes

Prevalence of tet(O/W) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

Species	NCBI Chromosome	NCBI Plasmid	NCBI WGS	NCBI GI	GRDI-AMR2
Bifidobacterium bifidum	0%	0%	0%	0%	0%
Bifidobacterium bifidum	0%	0%	1%	0%	0%
Bifidobacterium longum	0%	0%	0.42%	0%	0%
Bifidobacterium longum	0%	0%	0%	0%	0%
Mobiluncus mulieris	0%	0%	0%	0%	0%
Mobiluncus mulieris	0%	0%	14.71%	0%	0%
Ruthenibacterium lactatiformans	0%	0%	0%	0%	0%
Ruthenibacterium lactatiformans	0%	0%	46.67%	0%	0%
Streptococcus equi	0%	0%	0%	0%	0%
Streptococcus equi	0%	0%	0.23%	0%	0%

Show Perfect Only

Detection Models

protein homolog model

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 900

Protein
DNA

>gb|AAR29969.1|+|tet(O/W) [Megasphaera elsdenii]
MKIINLGILAHVDAGKTTLTESLLYTSGAIAELGSVDEGTTRTDTMNLERQRGITIQTAVTSFQWEDVKVNIIDTPGHMDFLAEVYRSLA
VLDGAILVISAKDGVQAQTRILFHALRKMNIPTVIFINKIDQAGVDLQSVVQSVRDKLSADIIIKQTVSLSPEIVLEENTDIEAWDAVIE
NNDALLEKYIAGEPISQEKLAREEQRRVQEASLFPVYHGSAKKGLGIQPLMDAVTGLFQPIGEQGSATLCGSVFKVEYTDCGQRRVYLRL
YSGTLRLRDTVALAGREKLKITEMRIPSKGEIVRTDTAYPGEIVILPSDSVRLNDVLGDQTRLPRKRWREAPLPMLRTTIAPKTAAQRER
LLDALTQLADTDPLLRCEVDSITHEIILSFLGRVQLEVVSALLSEKYKIETVVKEPTVIYMERPLKAASHTIHIEVPPNPFWASIGLSVT
PLPLGSGVQYESRVSLGYLNQSFQNAVRDGIRYGLEQGLFGWNVTDCKICFEYGLYYSPVSTPADFRSLAPIVLEQALKESGTQLLEPYL
SFTLYAPQEYLSRAYHDAPKYCATIETAQVKKDEVVFTGEIPARCIQAYRTDLAFYTNGQSVCLTELKGYQAAVGQPVIQPRRPNNRLDK
VRHMFQKVM

>gb|AY485122.1|+|1-1920|tet(O/W) [Megasphaera elsdenii]
ATGAAAATAATTAACTTAGGCATTCTGGCTCACGTTGACGCAGGAAAGACAACATTAACGGAAAGTTTATTGTATACCAGTGGTGCAATT
GCAGAACTAGGGAGCGTAGATGAAGGCACAACAAGGACAGATACAATGAATTTGGAGCGTCAAAGGGGAATCACTATCCAGACAGCAGTG
ACATCTTTTCAGTGGGAGGATGTAAAAGTCAACATTATAGATACGCCAGGCCATATGGATTTTTTGGCGGAGGTGTACCGCTCTTTGGCT
GTTTTAGATGGGGCCATCTTGGTGATCTCCGCGAAAGATGGCGTGCAGGCCCAGACCCGTATTCTGTTCCATGCCCTGCGGAAAATGAAC
ATTCCCACCGTTATCTTTATCAACAAGATCGACCAGGCTGGCGTTGATTTGCAGAGCGTGGTTCAGTCTGTTCGGGATAAGCTCTCCGCC
GATATTATCATCAAGCAGACGGTGTCGCTGTCCCCGGAAATAGTCCTGGAGGAAAATACCGACATAGAAGCATGGGATGCGGTCATCGAA
AATAACGATGCATTATTGGAAAAGTATATCGCAGGAGAACCAATCAGCCAGGAAAAACTTGCGCGGGAGGAACAGCGGCGGGTTCAAGAA
GCCTCCCTGTTTCCGGTCTATCATGGCAGCGCCAAAAAGGGCCTTGGCATTCAACCGTTGATGGATGCGGTGACAGGACTGTTCCAACCG
ATTGGGGAACAGGGGAGCGCCACCCTATGCGGCAGCGTTTTCAAGGTTGAGTACACCGATTGCGGCCAGCGGCGTGTCTATCTGCGGCTA
TACAGCGGAACGCTGCGCCTGCGGGATACGGTGGCCCTGGCCGGGAGAGAAAAGCTGAAAATCACAGAGATGCGTATTCCATCCAAAGGG
GAAATTGTTCGGACAGACACCGCTTATCCGGGCGAAATTGTTATCCTTCCCAGCGACAGCGTGAGGTTAAACGATGTATTAGGGGATCAA
ACCCGGCTCCCTCGTAAAAGGTGGCGCGAGGCCCCCCTCCCCATGCTGCGGACGACGATTGCGCCGAAAACGGCAGCGCAAAGAGAACGG
CTGCTGGACGCTCTTACGCAACTTGCGGATACTGACCCGCTTTTGCGCTGCGAAGTGGATTCCATCACCCATGAGATCATTCTTTCTTTT
TTGGGCCGGGTGCAGTTGGAGGTCGTTTCCGCTTTGCTGTCGGAAAAATACAAGATTGAAACAGTGGTAAAGGAACCCACCGTCATTTAT
ATGGAGCGGCCGCTCAAAGCAGCCAGCCACACCATCCATATCGAGGTGCCGCCCAACCCGTTTTGGGCATCTATCGGACTGTCTGTTACA
CCACTCCCGCTTGGCTCCGGCGTACAATACGAGAGCCGGGTTTCGCTGGGATACTTGAACCAGAGTTTTCAAAACGCTGTCAGGGATGGT
ATCCGTTACGGGCTGGAGCAGGGCTTGTTCGGCTGGAACGTAACGGACTGTAAGATTTGCTTTGAATACGGGCTTTATTACAGTCCAGTC
AGCACGCCGGCGGACTTCCGCTCATTGGCCCCGATTGTATTGGAACAGGCATTGAAGGAATCGGGGACGCAGCTGCTGGAACCTTATCTC
TCCTTCACCCTCTATGCGCCCCAGGAATACCTTTCCAGGGCTTATCATGATGCACCGAAATACTGTGCCACCATCGAAACGGCCCAGGTA
AAAAAGGATGAAGTTGTCTTTACTGGCGAGATTCCCGCCCGCTGTATACAGGCATACCGTACTGATCTGGCCTTTTACACCAACGGGCAG
AGCGTATGCCTTACAGAGCTAAAAGGGTATCAGGCCGCTGTCGGCCAGCCGGTCATCCAGCCCCGCCGTCCAAACAACCGCCTGGACAAG
GTGCGCCATATGTTTCAGAAGGTAATGTAA

Curator Acknowledgements

Curator	Description	Most Recent Edit

tet(O/W)

Prevalence: protein homolog model (view sequences)

Graph