tetB(P)

Accession ARO:3000195
Synonym(s)tetP
DefinitionTetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P), a tetracycline efflux protein.
AMR Gene Familytetracycline-resistant ribosomal protection protein
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic target protection
Classification8 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ tetracycline-resistant ribosomal protection protein [AMR Gene Family]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic doxycycline [Antibiotic]
+ confers_resistance_to_antibiotic minocycline [Antibiotic]
+ confers_resistance_to_antibiotic chlortetracycline [Antibiotic]
+ confers_resistance_to_antibiotic demeclocycline [Antibiotic]
+ confers_resistance_to_antibiotic oxytetracycline [Antibiotic]
Publications

Roberts MC. 2005. FEMS Microbiol Lett 245(2): 195-203. Update on acquired tetracycline resistance genes. (PMID 15837373)

Resistomes

Prevalence of tetB(P) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Clostridium perfringens0%18.75%25.24%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1200


>gb|AAA20117.1|+|tetB(P) [Clostridium perfringens]
MKKIINIGIVAHVDAGKTTITENLLYYSGAIKSVGRVDLGNTQTDSMELERKRGITIKSSTISFNWNNVKVNIIDTPGHVDFISEVERSL
NSLDGAILVISGVEGIQSQTRILFDTLKELNIPTIIFVNKLDRIGANFNKVFEEIKKNMSNKVVRLQEVYDVGSKAVYIKKLFDTCIIND
DAINVLSDLDEAFLERYIGGIEPDKEEIQEKLSLYAREGSLYPVFCGAAAIGLGIEDLLDGICSYFPFASNDCESDLSGVVFKIERTSKN
EKKVYVRLFGGKISVRDKIQVPNKEIAEKVKKINRLENGGVVEAQRIEAGDIGILYGLTSFQVGDVIGISNDKIKNISIAKPALKTTISA
IDKEKNPELFKALTLLAEEDPLLAFAMNDIDKEIYVNLFGEVQMEILSSMLDDLYGIKVEFSNIETIYKETPKGFGASIMHMQEDLNPFW
ATVGLEIEPAGRGEGLRYISNVSVGSLPKSFQNAIEEAVIKTSKQGLFGWEVTDVKVTLSCGEFFSPASTPADFRNVTPMVFMEALYKAQ
TVLLEPLHEFELKIPQNALSKAVWDLETMRATFDNPIVIGDEFSIKGLIPVENSKEYKMKIASYTEGRGMFVTKFYGYKEASAEFSKARK
KTTYDPLNKKEYLLHKLNAIRD


>gb|L20800|+|2309-4267|tetB(P) [Clostridium perfringens]
ATGAAGAAAATAATTAATATAGGAATCGTAGCACACGTGGATGCAGGAAAAACAACTATAACAGAAAACTTATTATATTATAGTGGAGCT
ATAAAATCAGTTGGAAGAGTTGATTTAGGCAATACACAGACGGATTCTATGGAGCTTGAGCGTAAGAGAGGAATTACCATTAAATCGTCA
ACCATATCTTTTAATTGGAATAATGTTAAGGTGAATATTATTGATACTCCAGGACATGTGGATTTTATTTCGGAAGTTGAACGTTCATTA
AATAGCTTAGATGGAGCAATACTAGTTATATCAGGAGTAGAGGGGATTCAGTCACAAACAAGAATATTATTTGACACATTAAAGGAGTTA
AATATTCCAACAATAATTTTTGTAAATAAGCTAGATAGAATTGGGGCAAATTTCAACAAAGTATTTGAAGAAATAAAGAAGAATATGTCC
AATAAAGTAGTTAGATTACAAGAAGTATATGATGTAGGAAGCAAAGCTGTTTATATAAAAAAACTATTTGATACATGCATAATAAATGAT
GATGCTATTAATGTTTTATCAGACTTAGACGAAGCATTTTTAGAAAGATATATTGGTGGAATAGAACCTGATAAAGAAGAAATACAAGAA
AAGCTTTCATTATATGCAAGAGAAGGAAGTCTATATCCAGTATTTTGTGGTGCTGCAGCAATTGGACTTGGAATTGAAGATTTATTAGAT
GGAATTTGTAGTTATTTTCCATTTGCAAGTAATGATTGTGAAAGTGATTTATCTGGGGTAGTATTTAAAATCGAAAGAACAAGTAAAAAT
GAAAAGAAGGTTTATGTAAGATTATTTGGAGGAAAAATATCTGTAAGAGATAAAATTCAAGTACCTAATAAGGAGATAGCAGAAAAAGTA
AAGAAAATTAATAGGTTAGAAAATGGGGGAGTTGTTGAAGCACAGAGGATAGAAGCAGGGGATATAGGTATTTTATATGGACTTACAAGT
TTCCAAGTGGGAGATGTTATTGGAATTTCAAATGATAAAATTAAAAATATATCTATAGCTAAACCAGCATTAAAAACAACAATTTCTGCA
ATTGATAAAGAAAAAAATCCAGAGCTATTTAAAGCATTAACATTACTTGCAGAGGAAGATCCACTACTCGCCTTCGCGATGAATGACATA
GATAAAGAAATTTATGTCAACTTATTCGGTGAAGTTCAAATGGAAATACTAAGTTCCATGTTAGATGATTTATATGGAATAAAAGTAGAG
TTTTCGAATATTGAGACTATCTATAAGGAAACACCTAAAGGTTTTGGAGCGTCAATAATGCATATGCAGGAAGACTTAAATCCATTTTGG
GCGACAGTAGGCTTAGAAATAGAACCAGCAGGGAGAGGCGAAGGTCTTAGGTATATTTCTAATGTTTCAGTAGGGTCATTGCCAAAATCT
TTTCAAAATGCAATTGAAGAAGCAGTTATTAAGACAAGTAAACAAGGATTATTTGGATGGGAGGTTACAGATGTAAAAGTCACTCTTAGC
TGTGGTGAATTTTTTAGTCCAGCCAGCACTCCAGCAGATTTTAGAAATGTGACACCTATGGTATTCATGGAAGCATTATATAAAGCACAA
ACTGTTTTATTAGAGCCATTACATGAGTTTGAGTTAAAGATTCCTCAAAATGCTTTAAGCAAAGCGGTATGGGATTTAGAAACTATGAGG
GCAACCTTTGATAATCCTATTGTTATAGGGGATGAATTCTCAATAAAGGGATTAATTCCAGTAGAAAATTCAAAAGAATATAAAATGAAA
ATAGCTTCATATACAGAAGGTAGAGGAATGTTTGTGACAAAATTTTATGGGTATAAGGAAGCTTCAGCTGAATTTTCAAAAGCACGCAAA
AAAACAACGTATGATCCATTGAATAAAAAAGAGTATTTGCTTCATAAACTAAACGCAATTAGAGATTAA