tetB(P)

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Accession ARO:3000195
Synonym(s)tetP
CARD Short NametetB(P)
DefinitionTetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P), a tetracycline efflux protein.
AMR Gene Familytetracycline-resistant ribosomal protection protein
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Sequence VariantsBacillus anthracisg+wgs, Bacillus cereusg+wgs, Bacillus thuringiensisg+wgs, Clostridium botulinumwgs, Clostridium butyricumwgs, Clostridium perfringensg+p+wgs, Enterococcus faeciump+wgs, Paenibacillus mucilaginosusg+wgs, Paeniclostridium sordelliig+wgs, Peptacetobacter hiranonisg+wgs
Classification7 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ tetracycline-resistant ribosomal protection protein [AMR Gene Family]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic doxycycline [Antibiotic]
+ confers_resistance_to_antibiotic minocycline [Antibiotic]
+ confers_resistance_to_antibiotic chlortetracycline [Antibiotic]
+ confers_resistance_to_antibiotic demeclocycline [Antibiotic]
+ confers_resistance_to_antibiotic oxytetracycline [Antibiotic]
Publications

Roberts MC. 2005. FEMS Microbiol Lett 245(2): 195-203. Update on acquired tetracycline resistance genes. (PMID 15837373)
Resistomes

Prevalence of tetB(P) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Bacillus anthracis100%0%77.63%0%
Bacillus cereus97.85%0%84.25%0%
Bacillus thuringiensis100%0%88.48%0%
Clostridium botulinum0%0%0.27%0%
Clostridium butyricum0%0%13.73%0%
Clostridium perfringens2.5%7.73%17.36%0%
Enterococcus faecium0%0.06%0.03%0%
Paenibacillus mucilaginosus80%0%100%0%
Paeniclostridium sordellii25%0%37.29%0%
Peptacetobacter hiranonis100%0%100%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|AAA20117.1|+|tetB(P) [Clostridium perfringens]
MKKIINIGIVAHVDAGKTTITENLLYYSGAIKSVGRVDLGNTQTDSMELERKRGITIKSSTISFNWNNVKVNIIDTPGHVDFISEVERSL
NSLDGAILVISGVEGIQSQTRILFDTLKELNIPTIIFVNKLDRIGANFNKVFEEIKKNMSNKVVRLQEVYDVGSKAVYIKKLFDTCIIND
DAINVLSDLDEAFLERYIGGIEPDKEEIQEKLSLYAREGSLYPVFCGAAAIGLGIEDLLDGICSYFPFASNDCESDLSGVVFKIERTSKN
EKKVYVRLFGGKISVRDKIQVPNKEIAEKVKKINRLENGGVVEAQRIEAGDIGILYGLTSFQVGDVIGISNDKIKNISIAKPALKTTISA
IDKEKNPELFKALTLLAEEDPLLAFAMNDIDKEIYVNLFGEVQMEILSSMLDDLYGIKVEFSNIETIYKETPKGFGASIMHMQEDLNPFW
ATVGLEIEPAGRGEGLRYISNVSVGSLPKSFQNAIEEAVIKTSKQGLFGWEVTDVKVTLSCGEFFSPASTPADFRNVTPMVFMEALYKAQ
TVLLEPLHEFELKIPQNALSKAVWDLETMRATFDNPIVIGDEFSIKGLIPVENSKEYKMKIASYTEGRGMFVTKFYGYKEASAEFSKARK
KTTYDPLNKKEYLLHKLNAIRD


>gb|L20800.1|+|2309-4267|tetB(P) [Clostridium perfringens]
ATGAAGAAAATAATTAATATAGGAATCGTAGCACACGTGGATGCAGGAAAAACAACTATAACAGAAAACTTATTATATTATAGTGGAGCT
ATAAAATCAGTTGGAAGAGTTGATTTAGGCAATACACAGACGGATTCTATGGAGCTTGAGCGTAAGAGAGGAATTACCATTAAATCGTCA
ACCATATCTTTTAATTGGAATAATGTTAAGGTGAATATTATTGATACTCCAGGACATGTGGATTTTATTTCGGAAGTTGAACGTTCATTA
AATAGCTTAGATGGAGCAATACTAGTTATATCAGGAGTAGAGGGGATTCAGTCACAAACAAGAATATTATTTGACACATTAAAGGAGTTA
AATATTCCAACAATAATTTTTGTAAATAAGCTAGATAGAATTGGGGCAAATTTCAACAAAGTATTTGAAGAAATAAAGAAGAATATGTCC
AATAAAGTAGTTAGATTACAAGAAGTATATGATGTAGGAAGCAAAGCTGTTTATATAAAAAAACTATTTGATACATGCATAATAAATGAT
GATGCTATTAATGTTTTATCAGACTTAGACGAAGCATTTTTAGAAAGATATATTGGTGGAATAGAACCTGATAAAGAAGAAATACAAGAA
AAGCTTTCATTATATGCAAGAGAAGGAAGTCTATATCCAGTATTTTGTGGTGCTGCAGCAATTGGACTTGGAATTGAAGATTTATTAGAT
GGAATTTGTAGTTATTTTCCATTTGCAAGTAATGATTGTGAAAGTGATTTATCTGGGGTAGTATTTAAAATCGAAAGAACAAGTAAAAAT
GAAAAGAAGGTTTATGTAAGATTATTTGGAGGAAAAATATCTGTAAGAGATAAAATTCAAGTACCTAATAAGGAGATAGCAGAAAAAGTA
AAGAAAATTAATAGGTTAGAAAATGGGGGAGTTGTTGAAGCACAGAGGATAGAAGCAGGGGATATAGGTATTTTATATGGACTTACAAGT
TTCCAAGTGGGAGATGTTATTGGAATTTCAAATGATAAAATTAAAAATATATCTATAGCTAAACCAGCATTAAAAACAACAATTTCTGCA
ATTGATAAAGAAAAAAATCCAGAGCTATTTAAAGCATTAACATTACTTGCAGAGGAAGATCCACTACTCGCCTTCGCGATGAATGACATA
GATAAAGAAATTTATGTCAACTTATTCGGTGAAGTTCAAATGGAAATACTAAGTTCCATGTTAGATGATTTATATGGAATAAAAGTAGAG
TTTTCGAATATTGAGACTATCTATAAGGAAACACCTAAAGGTTTTGGAGCGTCAATAATGCATATGCAGGAAGACTTAAATCCATTTTGG
GCGACAGTAGGCTTAGAAATAGAACCAGCAGGGAGAGGCGAAGGTCTTAGGTATATTTCTAATGTTTCAGTAGGGTCATTGCCAAAATCT
TTTCAAAATGCAATTGAAGAAGCAGTTATTAAGACAAGTAAACAAGGATTATTTGGATGGGAGGTTACAGATGTAAAAGTCACTCTTAGC
TGTGGTGAATTTTTTAGTCCAGCCAGCACTCCAGCAGATTTTAGAAATGTGACACCTATGGTATTCATGGAAGCATTATATAAAGCACAA
ACTGTTTTATTAGAGCCATTACATGAGTTTGAGTTAAAGATTCCTCAAAATGCTTTAAGCAAAGCGGTATGGGATTTAGAAACTATGAGG
GCAACCTTTGATAATCCTATTGTTATAGGGGATGAATTCTCAATAAAGGGATTAATTCCAGTAGAAAATTCAAAAGAATATAAAATGAAA
ATAGCTTCATATACAGAAGGTAGAGGAATGTTTGTGACAAAATTTTATGGGTATAAGGAAGCTTCAGCTGAATTTTCAAAAGCACGCAAA
AAAACAACGTATGATCCATTGAATAAAAAAGAGTATTTGCTTCATAAACTAAACGCAATTAGAGATTAA