tet36

Accession ARO:3000197
DefinitionTet36 is a tetracycline resistance gene found in Bacteroides similar to Tet(Q), and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein.
AMR Gene Familytetracycline-resistant ribosomal protection protein
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic target protection
Classification8 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ tetracycline-resistant ribosomal protection protein [AMR Gene Family]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic doxycycline [Antibiotic]
+ confers_resistance_to_antibiotic minocycline [Antibiotic]
+ confers_resistance_to_antibiotic chlortetracycline [Antibiotic]
+ confers_resistance_to_antibiotic demeclocycline [Antibiotic]
+ confers_resistance_to_antibiotic oxytetracycline [Antibiotic]
Publications

Whittle G, et al. 2003. Appl Environ Microbiol 69(7): 4151-4158. Identification of a new ribosomal protection type of tetracycline resistance gene, tet(36), from swine manure pits. (PMID 12839793)

Resistomes

Prevalence of tet36 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1200


>gb|CAD55718.1|+|tet36 [Bacteroides coprosuis DSM 18011]
MRTINIGILAHIDAGKTSITENLLFASGATIVRGSVDKGNTTTDSMDIEKRRGITVRASTTSIQWNDTKINIIDTPGHMDFLAEVERTFR
MLDGAILVVSAKEGIQAQTRLLFNVLQQLEIPTILFVNKIDREGVNLNQLYLEIQNSLSKDIIFMQSVEGKELTSSCTIHYISEKNRETI
LEKDDLLLEKYLSDTQLSNLDYWNSMVRLVQAAKLHPIYHGSAMYGIGIEDLLNSITTFIETSLPQENALSAYVYKIEHNKKEQKRAYLK
IIGGTLKSRKLYSLNGSDENLKIRGLKTFYSGDEIDVDEVFTNDIAIADHADNLMVGDYLGIMPNLFDKLNIPSPALKSSIHPAKVENRS
KLISAMNVLSVEDPSLAFSINADNNELEVSLYGATQREVILTLLEERFSVDAYFEEVKTIYKERLKTKSEYTIHIEVPPNPYWASIGLII
EPLPIGAGLVMESEISLGYLNRSFQNAVFDGVKKACESGLYGWEVTDLKVTFSHGIYYSPVSTPADFRSLAPYVFRLALQQADVELLEPI
LDFKLQIPLAVNARAITDINKMQGEISTITSDGDWTTILGNIPLDTSKEYSAEVSSYTQGLGVFVTRFSGYRPTNKKVSRSVELNEKDKL
MYMFEKESIK


>gb|AJ514254|+|1-1923|tet36 [Bacteroides coprosuis DSM 18011]
ATGAGAACTATAAATATAGGTATTCTTGCACATATTGATGCAGGAAAGACCTCCATTACAGAGAACTTGCTATTTGCGAGTGGAGCAACC
ATAGTACGTGGAAGTGTGGACAAAGGAAACACTACAACCGATTCGATGGATATCGAAAAACGAAGAGGTATCACAGTTAGAGCGTCTACA
ACATCTATTCAATGGAATGATACAAAGATTAATATCATCGACACTCCTGGACACATGGACTTTCTGGCAGAGGTAGAACGCACTTTTAGG
ATGCTAGATGGTGCTATACTTGTGGTGTCTGCCAAAGAGGGCATTCAAGCTCAAACAAGGTTGTTGTTCAATGTCCTGCAACAACTAGAA
ATACCTACAATTCTATTCGTCAACAAAATAGACAGAGAGGGAGTCAATCTAAATCAGCTTTATTTAGAGATACAAAATAGCCTTTCTAAA
GATATTATCTTTATGCAATCCGTTGAAGGCAAGGAATTAACATCTAGCTGTACAATACACTACATATCAGAAAAGAACAGAGAAACAATT
TTAGAGAAAGATGATCTCTTGCTTGAAAAATACTTGAGTGATACACAGCTTTCTAATTTAGATTATTGGAATTCAATGGTTCGTCTTGTT
CAAGCTGCTAAATTACATCCTATCTATCATGGTTCAGCAATGTATGGCATTGGTATTGAAGATTTGCTAAACTCAATCACTACTTTTATC
GAAACATCTCTACCTCAAGAGAACGCTTTGTCTGCCTATGTTTATAAAATTGAGCATAATAAGAAGGAACAGAAACGAGCCTATCTAAAG
ATTATAGGTGGAACCCTTAAATCTCGAAAATTATATAGCCTCAATGGCTCAGATGAGAATCTGAAGATAAGAGGTTTAAAGACCTTTTAC
TCAGGAGACGAAATAGATGTAGACGAAGTTTTTACAAATGATATTGCAATTGCAGATCATGCTGATAACTTAATGGTAGGAGATTATCTA
GGAATAATGCCAAACTTATTCGACAAATTGAATATTCCTAGTCCTGCTCTCAAATCGTCTATACATCCTGCAAAAGTAGAGAATAGGAGT
AAATTGATTTCTGCTATGAATGTATTATCAGTAGAAGATCCATCTTTGGCCTTTAGCATTAATGCTGATAATAATGAATTGGAGGTTTCG
CTTTATGGAGCAACTCAACGGGAGGTGATTTTGACTTTATTGGAAGAGAGATTTTCGGTAGATGCTTACTTTGAAGAGGTGAAAACTATC
TATAAAGAACGTCTTAAAACAAAATCGGAATACACCATTCATATCGAAGTGCCACCTAATCCGTATTGGGCATCTATTGGCTTGATTATA
GAGCCTTTGCCAATTGGGGCGGGACTTGTAATGGAGAGTGAAATATCATTGGGATATTTGAATCGATCCTTTCAGAATGCAGTATTCGAT
GGAGTCAAGAAAGCCTGTGAATCGGGTTTGTACGGTTGGGAAGTAACTGACCTTAAAGTCACTTTTTCTCACGGAATCTATTATAGCCCA
GTGAGTACACCTGCCGACTTTAGAAGTTTAGCACCTTATGTTTTTCGATTAGCTTTGCAACAAGCTGATGTTGAGTTATTGGAGCCAATC
TTAGATTTTAAATTGCAAATTCCACTAGCTGTGAATGCTAGAGCTATTACAGACATCAACAAGATGCAAGGCGAAATATCTACTATTACT
TCAGATGGTGATTGGACTACTATTTTGGGTAATATTCCTTTAGATACTAGTAAAGAATACTCAGCAGAGGTCAGTTCCTACACACAAGGC
TTGGGCGTTTTTGTTACTCGATTTTCGGGTTATCGACCTACCAACAAAAAGGTAAGCAGAAGTGTAGAACTGAATGAAAAAGATAAGCTG
ATGTATATGTTTGAGAAGGAAAGTATCAAATAA