tet(36)

Accession ARO:3000197
Synonym(s)tet36
CARD Short Nametet(36)
DefinitionTet(36) is a tetracycline resistance gene found in Bacteroides similar to Tet(Q), and binds to the ribosome to confer antibiotic resistance as a ribosomal protection protein.
AMR Gene Familytetracycline-resistant ribosomal protection protein
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Sequence VariantsClostridium botulinumg+wgs, Clostridium septicumg+wgs, Clostridium sporogenesg+wgs, Elizabethkingia anopheliswgs, Elizabethkingia miricolawgs, Enterococcus faecaliswgs, Enterococcus faeciumwgs, Fusobacterium necrophorumwgs, Herbinix luporumg+wgs, Myroides odoratimimuswgs, Staphylococcus aureusp+wgs
Classification7 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic doxycycline [Antibiotic]
+ confers_resistance_to_antibiotic minocycline [Antibiotic]
+ confers_resistance_to_antibiotic chlortetracycline [Antibiotic]
+ confers_resistance_to_antibiotic demeclocycline [Antibiotic]
+ confers_resistance_to_antibiotic oxytetracycline [Antibiotic]
+ tetracycline-resistant ribosomal protection protein [AMR Gene Family]
Publications

Whittle G, et al. 2003. Appl Environ Microbiol 69(7): 4151-4158. Identification of a new ribosomal protection type of tetracycline resistance gene, tet(36), from swine manure pits. (PMID 12839793)

Resistomes

Prevalence of tet(36) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Clostridium botulinum56.72%0%43.48%0%
Clostridium septicum100%0%100%0%
Clostridium sporogenes100%0%88.03%0%
Elizabethkingia anophelis0%0%1.03%0%
Elizabethkingia miricola0%0%4.35%0%
Enterococcus faecalis0%0%0.08%0%
Enterococcus faecium0%0%0.07%0%
Fusobacterium necrophorum0%0%2.33%0%
Herbinix luporum100%0%50%0%
Myroides odoratimimus0%0%7.14%0%
Staphylococcus aureus0%0.56%0.01%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 300


>gb|CAD55718.1|+|tet(36) [Bacteroides coprosuis DSM 18011]
MRTINIGILAHIDAGKTSITENLLFASGATIVRGSVDKGNTTTDSMDIEKRRGITVRASTTSIQWNDTKINIIDTPGHMDFLAEVERTFR
MLDGAILVVSAKEGIQAQTRLLFNVLQQLEIPTILFVNKIDREGVNLNQLYLEIQNSLSKDIIFMQSVEGKELTSSCTIHYISEKNRETI
LEKDDLLLEKYLSDTQLSNLDYWNSMVRLVQAAKLHPIYHGSAMYGIGIEDLLNSITTFIETSLPQENALSAYVYKIEHNKKEQKRAYLK
IIGGTLKSRKLYSLNGSDENLKIRGLKTFYSGDEIDVDEVFTNDIAIADHADNLMVGDYLGIMPNLFDKLNIPSPALKSSIHPAKVENRS
KLISAMNVLSVEDPSLAFSINADNNELEVSLYGATQREVILTLLEERFSVDAYFEEVKTIYKERLKTKSEYTIHIEVPPNPYWASIGLII
EPLPIGAGLVMESEISLGYLNRSFQNAVFDGVKKACESGLYGWEVTDLKVTFSHGIYYSPVSTPADFRSLAPYVFRLALQQADVELLEPI
LDFKLQIPLAVNARAITDINKMQGEISTITSDGDWTTILGNIPLDTSKEYSAEVSSYTQGLGVFVTRFSGYRPTNKKVSRSVELNEKDKL
MYMFEKESIK


>gb|AJ514254.1|+|1-1923|tet(36) [Bacteroides coprosuis DSM 18011]
ATGAGAACTATAAATATAGGTATTCTTGCACATATTGATGCAGGAAAGACCTCCATTACAGAGAACTTGCTATTTGCGAGTGGAGCAACC
ATAGTACGTGGAAGTGTGGACAAAGGAAACACTACAACCGATTCGATGGATATCGAAAAACGAAGAGGTATCACAGTTAGAGCGTCTACA
ACATCTATTCAATGGAATGATACAAAGATTAATATCATCGACACTCCTGGACACATGGACTTTCTGGCAGAGGTAGAACGCACTTTTAGG
ATGCTAGATGGTGCTATACTTGTGGTGTCTGCCAAAGAGGGCATTCAAGCTCAAACAAGGTTGTTGTTCAATGTCCTGCAACAACTAGAA
ATACCTACAATTCTATTCGTCAACAAAATAGACAGAGAGGGAGTCAATCTAAATCAGCTTTATTTAGAGATACAAAATAGCCTTTCTAAA
GATATTATCTTTATGCAATCCGTTGAAGGCAAGGAATTAACATCTAGCTGTACAATACACTACATATCAGAAAAGAACAGAGAAACAATT
TTAGAGAAAGATGATCTCTTGCTTGAAAAATACTTGAGTGATACACAGCTTTCTAATTTAGATTATTGGAATTCAATGGTTCGTCTTGTT
CAAGCTGCTAAATTACATCCTATCTATCATGGTTCAGCAATGTATGGCATTGGTATTGAAGATTTGCTAAACTCAATCACTACTTTTATC
GAAACATCTCTACCTCAAGAGAACGCTTTGTCTGCCTATGTTTATAAAATTGAGCATAATAAGAAGGAACAGAAACGAGCCTATCTAAAG
ATTATAGGTGGAACCCTTAAATCTCGAAAATTATATAGCCTCAATGGCTCAGATGAGAATCTGAAGATAAGAGGTTTAAAGACCTTTTAC
TCAGGAGACGAAATAGATGTAGACGAAGTTTTTACAAATGATATTGCAATTGCAGATCATGCTGATAACTTAATGGTAGGAGATTATCTA
GGAATAATGCCAAACTTATTCGACAAATTGAATATTCCTAGTCCTGCTCTCAAATCGTCTATACATCCTGCAAAAGTAGAGAATAGGAGT
AAATTGATTTCTGCTATGAATGTATTATCAGTAGAAGATCCATCTTTGGCCTTTAGCATTAATGCTGATAATAATGAATTGGAGGTTTCG
CTTTATGGAGCAACTCAACGGGAGGTGATTTTGACTTTATTGGAAGAGAGATTTTCGGTAGATGCTTACTTTGAAGAGGTGAAAACTATC
TATAAAGAACGTCTTAAAACAAAATCGGAATACACCATTCATATCGAAGTGCCACCTAATCCGTATTGGGCATCTATTGGCTTGATTATA
GAGCCTTTGCCAATTGGGGCGGGACTTGTAATGGAGAGTGAAATATCATTGGGATATTTGAATCGATCCTTTCAGAATGCAGTATTCGAT
GGAGTCAAGAAAGCCTGTGAATCGGGTTTGTACGGTTGGGAAGTAACTGACCTTAAAGTCACTTTTTCTCACGGAATCTATTATAGCCCA
GTGAGTACACCTGCCGACTTTAGAAGTTTAGCACCTTATGTTTTTCGATTAGCTTTGCAACAAGCTGATGTTGAGTTATTGGAGCCAATC
TTAGATTTTAAATTGCAAATTCCACTAGCTGTGAATGCTAGAGCTATTACAGACATCAACAAGATGCAAGGCGAAATATCTACTATTACT
TCAGATGGTGATTGGACTACTATTTTGGGTAATATTCCTTTAGATACTAGTAAAGAATACTCAGCAGAGGTCAGTTCCTACACACAAGGC
TTGGGCGTTTTTGTTACTCGATTTTCGGGTTATCGACCTACCAACAAAAAGGTAAGCAGAAGTGTAGAACTGAATGAAAAAGATAAGCTG
ATGTATATGTTTGAGAAGGAAAGTATCAAATAA