| Accession | ARO:3000191 |
| Synonym(s) | tetA(Q) tetQ |
| CARD Short Name | tet(Q) |
| Definition | Tet(Q) is a ribosomal protection protein. Its gene is associated with a conjugative transposon and has been found in both Gram-positive and Gram-negative bacteria. |
| AMR Gene Family | tetracycline-resistant ribosomal protection protein |
| Drug Class | tetracycline antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Perfect Matches | Bacteroides caccaewgs, Bacteroides fragilisg+wgs, Bacteroides ovatusg+wgs, Bacteroides thetaiotaomicrong+wgs, Parabacteroides distasonisg+wgs, Phocaeicola doreig+wgs, Phocaeicola vulgatuswgs, Prevotella biviawgs, Prevotella intermediag+wgs |
| Resistomes with Sequence Variants | Alistipes putrediniswgs, Anaerostipes hadrusg+wgs, Bacteroides caccaeg+wgs, Bacteroides fragilisg+wgs+gi, Bacteroides ovatusg+wgs+gi, Bacteroides thetaiotaomicrong+wgs, Butyricimonas faecalisg+gi, Capnocytophaga ochraceag, Collinsella aerofacienswgs, Enterocloster clostridioformisg+wgs, Eubacterium limosumg+wgs, Eubacterium maltosivoransg+wgs, Muribaculaceae bacteriumgi, Paeniclostridium sordelliig+wgs, Parabacteroides distasonisg+wgs+gi, Phocaeicola doreig+wgs+gi, Phocaeicola massiliensiswgs, Phocaeicola vulgatusg+wgs+gi, Porphyromonas gingivaliswgs, Prevotella biviawgs, Prevotella intermediag+wgs, Riemerella anatipestiferg+wgs, Staphylococcus aureusp+wgs, Tannerella forsythiag |
| Classification | 7 ontology terms | Show |
| Parent Term(s) | 7 ontology terms | Show + tetracycline-resistant ribosomal protection protein [AMR Gene Family] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic doxycycline [Antibiotic] + confers_resistance_to_antibiotic minocycline [Antibiotic] + confers_resistance_to_antibiotic chlortetracycline [Antibiotic] + confers_resistance_to_antibiotic demeclocycline [Antibiotic] + confers_resistance_to_antibiotic oxytetracycline [Antibiotic] |
| Publications | Tribble GD, et al. 2010. Anaerobe 16(6): 604-609. Genetic analysis of mobile tetQ elements in oral Prevotella species. (PMID 20826220) Leng Z, et al. 1997. J Antimicrob Chemother 40(4): 551-559. Distribution and mobility of the tetracycline resistance determinant tetQ. (PMID 9372425) |
Prevalence of tet(Q) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Alistipes putredinis | 0% | 0% | 16% | 0% |
| Anaerostipes hadrus | 33.33% | 0% | 41.38% | 0% |
| Bacteroides caccae | 25% | 0% | 72.5% | 0% |
| Bacteroides fragilis | 61.54% | 0% | 42.44% | 45.45% |
| Bacteroides ovatus | 46.67% | 0% | 39.16% | 100% |
| Bacteroides thetaiotaomicron | 67.86% | 0% | 33.57% | 0% |
| Butyricimonas faecalis | 100% | 0% | 0% | 50% |
| Capnocytophaga ochracea | 16.67% | 0% | 0% | 0% |
| Collinsella aerofaciens | 0% | 0% | 0.75% | 0% |
| Enterocloster clostridioformis | 100% | 0% | 62.79% | 0% |
| Eubacterium limosum | 100% | 0% | 100% | 0% |
| Eubacterium maltosivorans | 100% | 0% | 100% | 0% |
| Muribaculaceae bacterium | 0% | 0% | 0% | 100% |
| Paeniclostridium sordellii | 50% | 0% | 88.14% | 0% |
| Parabacteroides distasonis | 69.23% | 0% | 56.54% | 50% |
| Phocaeicola dorei | 90.91% | 0% | 73.96% | 60% |
| Phocaeicola massiliensis | 0% | 0% | 73.08% | 0% |
| Phocaeicola vulgatus | 41.67% | 0% | 43.45% | 100% |
| Porphyromonas gingivalis | 0% | 0% | 3.45% | 0% |
| Prevotella bivia | 0% | 0% | 87.5% | 0% |
| Prevotella intermedia | 30.77% | 0% | 34.78% | 0% |
| Riemerella anatipestifer | 8.33% | 0% | 4.17% | 0% |
| Staphylococcus aureus | 0% | 1.64% | 0.2% | 0% |
| Tannerella forsythia | 33.33% | 0% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300