tet(Q)

Accession ARO:3000191
Synonym(s)tetA(Q) tetQ
CARD Short Nametet(Q)
DefinitionTet(Q) is a ribosomal protection protein. Its gene is associated with a conjugative transposon and has been found in both Gram-positive and Gram-negative bacteria.
AMR Gene Familytetracycline-resistant ribosomal protection protein
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Perfect MatchesBacteroides caccaewgs, Bacteroides fragilisg+wgs, Bacteroides ovatusg+wgs, Bacteroides thetaiotaomicrong+wgs, Parabacteroides distasonisg+wgs, Phocaeicola doreig+wgs, Phocaeicola vulgatuswgs, Prevotella biviawgs, Prevotella intermediag+wgs
Resistomes with Sequence VariantsAlistipes putrediniswgs, Anaerostipes hadrusg+wgs, Bacteroides caccaeg+wgs, Bacteroides fragilisg+wgs+gi, Bacteroides ovatusg+wgs+gi, Bacteroides thetaiotaomicrong+wgs, Butyricimonas faecalisg+gi, Capnocytophaga ochraceag, Collinsella aerofacienswgs, Enterocloster clostridioformisg+wgs, Eubacterium limosumg+wgs, Eubacterium maltosivoransg+wgs, Muribaculaceae bacteriumgi, Paeniclostridium sordelliig+wgs, Parabacteroides distasonisg+wgs+gi, Phocaeicola doreig+wgs+gi, Phocaeicola massiliensiswgs, Phocaeicola vulgatusg+wgs+gi, Porphyromonas gingivaliswgs, Prevotella biviawgs, Prevotella intermediag+wgs, Riemerella anatipestiferg+wgs, Staphylococcus aureusp+wgs, Tannerella forsythiag
Classification7 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ tetracycline-resistant ribosomal protection protein [AMR Gene Family]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic doxycycline [Antibiotic]
+ confers_resistance_to_antibiotic minocycline [Antibiotic]
+ confers_resistance_to_antibiotic chlortetracycline [Antibiotic]
+ confers_resistance_to_antibiotic demeclocycline [Antibiotic]
+ confers_resistance_to_antibiotic oxytetracycline [Antibiotic]
Publications

Tribble GD, et al. 2010. Anaerobe 16(6): 604-609. Genetic analysis of mobile tetQ elements in oral Prevotella species. (PMID 20826220)

Leng Z, et al. 1997. J Antimicrob Chemother 40(4): 551-559. Distribution and mobility of the tetracycline resistance determinant tetQ. (PMID 9372425)

Resistomes

Prevalence of tet(Q) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Alistipes putredinis0%0%18%0%0%
Anaerostipes hadrus33.33%0%93.1%0%0%
Bacteroides caccae25%0%77.5%0%0%
Bacteroides fragilis61.54%0%75.33%45.45%0%
Bacteroides ovatus46.67%0%77.95%100%0%
Bacteroides thetaiotaomicron67.86%0%69.93%0%0%
Butyricimonas faecalis100%0%0%50%0%
Capnocytophaga ochracea16.67%0%0%0%0%
Collinsella aerofaciens0%0%0.75%0%0%
Enterocloster clostridioformis100%0%95.35%0%0%
Eubacterium limosum100%0%100%0%0%
Eubacterium maltosivorans100%0%100%0%0%
Muribaculaceae bacterium0%0%0%100%0%
Paeniclostridium sordellii50%0%91.53%0%0%
Parabacteroides distasonis69.23%0%80.84%50%0%
Phocaeicola dorei90.91%0%90.62%60%0%
Phocaeicola massiliensis0%0%80.77%0%0%
Phocaeicola vulgatus41.67%0%75.49%100%0%
Porphyromonas gingivalis0%0%3.45%0%0%
Prevotella bivia0%0%87.5%0%0%
Prevotella intermedia30.77%0%34.78%0%0%
Riemerella anatipestifer8.33%0%6.94%0%0%
Staphylococcus aureus0%1.64%0.23%0%0%
Tannerella forsythia33.33%0%0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 300


>gb|CAA79727.1|+|tet(Q) [Bacteroides fragilis]
MRFDNASIVVYYCLIQMNIINLGILAHIDAGKTSVTENLLFASGATEKCGRVDNGDTITDSMDIEKRRGITVRASTTSIIWNGVKCNIID
TPGHMDFIAEVERTFKMLDGAVLILSAKEGIQAQTKLLFNTLQKLQIPTIIFINKIDRDGVNLERLYLDIKTNLSQDVLFMQTVVDGLVY
PICSQTYIKEEYKEFVCNHDDNILERYLADSEISPADYWNTIIDLVAKAKVYPVLHGSAMFNIGINELLDAISSFILPPESVSNRLSAYL
YKIEHDPKGHKRSFLKIIDGSLRLRDIVRINDSEKFIKIKNLKTIYQGREINVDEVGANDIAIVEDMEDFRIGDYLGTKPCLIQGLSHQH
PALKSSVRPDRSEERSKVISALNTLWIEDPSLSFSINSYSDELEISLYGLTQKEIIQTLLEERFSVKVHFDEIKTIYKERPVKKVNKIIQ
IEVPPNPYWATIGLTLEPLPLGTGLQIESDISYGYLNHSFQNAVFEGIRMSCQSGLHGWEVTDLKVTFTQAEYYSPVSTPADFRQLTPYV
FRLALQQSGVDILEPMLYFELQIPQAASSKAITDLQKMMSEIEDISCNNEWCHIKGKVPLNTSKDYASEVSSYTKGLGVFMVKPCGYQIT
KGDYSDNIRMNEKDKLLFMFQKSMSSK


>gb|Z21523.1|+|1-1974|tet(Q) [Bacteroides fragilis]
GTGCGTTTCGACAATGCATCTATTGTAGTATATTATTGCTTAATCCAAATGAATATTATAAATTTAGGAATTCTTGCTCACATTGATGCA
GGAAAAACTTCCGTAACCGAGAATCTGCTGTTTGCCAGTGGAGCAACGGAAAAGTGCGGCCGTGTGGATAATGGTGACACCATAACAGAC
TCTATGGATATAGAGAAACGTAGAGGAATTACTGTTCGGGCTTCTACGACATCTATTATCTGGAATGGAGTGAAATGCAATATCATTGAC
ACTCCGGGACACATGGATTTTATTGCGGAAGTGGAGCGGACATTCAAAATGCTTGATGGAGCAGTCCTCATCTTATCCGCAAAGGAAGGC
ATACAAGCGCAAACAAAGTTGCTGTTCAATACTTTACAAAAACTGCAAATCCCGACAATTATATTTATCAATAAAATTGACCGTGACGGT
GTGAATTTAGAGCGTTTGTATCTGGATATAAAAACAAATCTGTCTCAAGATGTCCTGTTTATGCAAACTGTTGTCGATGGATTGGTTTAT
CCGATTTGCTCCCAAACATATATAAAGGAAGAATACAAAGAATTTGTATGCAACCATGACGACAATATATTAGAACGATATTTGGCGGAT
AGCGAAATTTCACCGGCTGATTATTGGAATACGATAATCGATCTTGTGGCAAAAGCCAAAGTCTATCCGGTACTACATGGATCAGCAATG
TTCAATATCGGTATCAATGAGTTGTTGGACGCCATCTCTTCTTTTATACTTCCTCCAGAATCAGTCTCAAACAGACTTTCAGCTTATCTC
TATAAGATAGAGCATGACCCCAAAGGACATAAAAGAAGTTTTCTAAAAATAATTGACGGAAGTCTGAGACTTCGAGACATTGTAAGAATC
AACGATTCGGAAAAATTCATCAAGATTAAAAATCTAAAGACTATTTATCAGGGCAGAGAGATAAATGTTGATGAAGTGGGGGCCAATGAT
ATCGCGATTGTAGAAGATATGGAAGATTTTCGAATCGGAGATTATTTAGGTACTAAACCTTGTTTGATTCAAGGGTTATCTCATCAGCAT
CCCGCTCTCAAATCCTCCGTCCGGCCAGACAGGTCCGAAGAGAGAAGCAAGGTGATATCCGCTCTGAATACATTGTGGATTGAAGACCCG
TCTTTGTCCTTTTCCATAAACTCATATAGTGATGAATTGGAAATCTCGTTATATGGTTTGACACAAAAGGAAATCATACAGACATTGCTG
GAAGAACGATTTTCCGTAAAGGTCCATTTTGATGAGATCAAGACTATCTACAAAGAACGACCTGTAAAAAAGGTCAATAAGATTATTCAG
ATCGAAGTGCCACCCAACCCTTACTGGGCCACAATAGGGCTGACGCTTGAACCCTTGCCGTTAGGGACAGGGTTGCAAATCGAAAGTGAC
ATCTCCTATGGTTATCTGAACCATTCTTTTCAAAATGCCGTTTTTGAAGGGATTCGTATGTCTTGCCAATCTGGTTTACATGGATGGGAA
GTGACTGATCTGAAAGTAACTTTTACTCAAGCCGAGTATTATAGCCCGGTAAGTACACCTGCTGATTTCAGACAGCTGACCCCTTATGTC
TTCAGGCTGGCCTTGCAACAGTCAGGTGTGGACATTCTCGAACCGATGCTCTATTTTGAGTTGCAGATACCCCAAGCGGCAAGTTCCAAA
GCTATTACAGATTTGCAAAAAATGATGTCTGAGATTGAAGACATCAGTTGCAATAATGAGTGGTGTCATATTAAAGGGAAAGTTCCATTA
AATACAAGTAAAGACTACGCCTCAGAAGTAAGTTCATACACTAAGGGCTTAGGCGTTTTTATGGTCAAGCCATGCGGGTATCAAATAACA
AAAGGCGATTATTCTGATAATATCCGCATGAACGAAAAAGATAAACTTTTATTCATGTTCCAAAAATCAATGTCATCAAAATAA

Curator Acknowledgements
Curator Description Most Recent Edit