otrC

Accession ARO:3002894
DefinitionotrC is a tetracycline resistance efflux pump found in Streptomyces rimosus
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump
Drug Classpleuromutilin antibiotic, nitroimidazole antibiotic, penam, acridine dye, peptide antibiotic, cephalosporin, rifamycin antibiotic, tetracycline antibiotic, fluoroquinolone antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification18 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family]
Publications

Yu L, et al. 2012. BMC Biotechnol. 12:52 Molecular cloning and functional characterization of an ATP-binding cassette transporter OtrC from Streptomyces rimosus. (PMID 22906146)

Resistomes

Prevalence of otrC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 650


>gb|AAR96051.1|+|otrC [Streptomyces rimosus]
MTRKTISNGARNAVEVRGLVKHFGEVKAVDGVDLDVREGTVLGVLGPXGAAXXRGALPAHVXGPDAGRRPWRFXTWCANRRALRRTIGXH
RPVRXGRRESFSGRENLYMIGRXLDLSRKDARARADELLERFSLTEAAGRAAAKYSGGMRRRLDLAASMIGRPAVLYLDEPTTGLDPRTR
NEVWDEVRSMVRDGATVLLTTQYMEEAEQLAHELTVIDRGRVIADGKVDELKTKVGGRTLQIRPAHAAELDRMVGAIAQAGLDGIAGATA
DHEDGVVNVPIVSDEQLSAVVGMLGERGFTISGHQHPSAQLXEVFLAITGQKTSEAADGGPQDGPQDQQGVQDKQYEEVPA


>gb|AY509111|+|1-1056|otrC [Streptomyces rimosus]
ATGACGCGAAAGACGATATCCAACGGCGCGAGGAACGCCGTCGAAGTGCGGGGACTGGTCAAGCACTTCGGCGAGGTGAAGGCCGTGGAC
GGGGTGGATCTCGATGTGAGGGAAGGCACCGTGCTCGGTGTGCTCGGGCCGANCGGCGCGGCAANANAACGTGGTGCGCTGCCTGCCCAC
GTTGNTGGTCCGGACGCCGGCAGGCGACCGTGGCGGTTTNAAACGTGGTGCGCCAACCGGCGCGCGTTGCGCCGCACGATCGGCCNTCAC
CGGCCAGTACGCNTCGGTCGACGAGAAAGCTTCTCCGGCCGNGAGAACCTGTACATGATCGGCCGCNTGCTGGACCTCTCCCGCAAGGAC
GCCCGCGCGCGGGCCGACGAGCTGCTGGAGCGGTTCTCCCTCACCGAGGCCGCCGGCCGGGCCGCCGCCAAGTACTCCGGCGGTATGCGC
CGCCGCCTCGACCTGGCCGCCTCCATGATCGGCAGGCCCGCGGTGCTGTATCTGGACGAGCCGACGACGGGCCTCGACCCCCGCACCCGC
AACGAGGTGTGGGACGAGGTCCGCAGCATGGTGCGCGACGGCGCCACGGTCCTGCTCACCACCCAGTACATGGAAGAGGCCGAGCAGCTG
GCCCACGAGCTGACGGTCATCGACCGCGGCCGGGTCATCGCCGACGGCAAGGTGGACGAGCTGAAGACCAAGGTCGGCGGCCGTACGCTC
CAGATACGCCCGGCGCACGCCGCCGAGCTGGACCGGATGGTCGGCGCCATCGCGCAGGCCGGCCTGGACGGCATCGCGGGCGCCACCGCC
GACCACGAGGACGGCGTGGTCAACGTCCCGATCGTCAGCGACGAGCAGCTGTCCGCCGTGGTCGGCATGCTCGGCGAGCGGGGCTTCACG
ATCTCCGGGCATCAACACCCATCTGCCCAGCTGNACGAGGTGTTCCTGGCCATCACCGGCCAGAAGACCTCGGAGGCCGCCGACGGCGGC
CCGCAGGACGGACCGCAGGACCAGCAGGGCGTTCAGGACAAGCAGTACGAGGAGGTTCCGGCATGA