Accession ARO:3000825
DefinitionThe robA protein is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, disinfecting agents and antiseptics, cephalosporin, penam, glycylcycline, rifamycin antibiotic, phenicol antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification24 ontology terms | Show
Parent Term(s)2 ontology terms | Show
2 ontology terms | Show

White DG, et al. 1997. J Bacteriol 179(19): 6122-6126. Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli. (PMID 9324261)

Rosenberg EY, et al. 2003. Mol Microbiol 48(6): 1609-1619. Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein. (PMID 12791142)