acrA

Accession ARO:3000207
DefinitionProtein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrA represents the periplasmic portion of the transport protein.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, penam, cephalosporin, glycylcycline, phenicol antibiotic, rifamycin antibiotic, triclosan, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification24 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Sub-Term(s)
3 ontology terms | Show
Publications

Mikolosko J, et al. 2006. Structure 14(3): 577-587. Conformational flexibility in the multidrug efflux system protein AcrA. (PMID 16531241)

Zgurskaya HI and Nikaido H. 2000. Mol Microbiol 37(2): 219-225. Multidrug resistance mechanisms: drug efflux across two membranes. (PMID 10931319)

Poole K. 2004. Clin Microbiol Infect 10(1): 12-26. Efflux-mediated multiresistance in Gram-negative bacteria. (PMID 14706082)

Higgins MK, et al. 2004. Proc Natl Acad Sci U S A 101(27): 9994-9999. Structure of the periplasmic component of a bacterial drug efflux pump. (PMID 15226509)