Klebsiella pneumoniae acrA

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Accession ARO:3004041
CARD Short NameKpne_acrA
DefinitionAcrA is a subunit of the AcrAB multidrug efflux system that is found in K. pneumoniae, which is encoded by the acrRAB operon.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, disinfecting agents and antiseptics, phenicol antibiotic, rifamycin antibiotic, penam, glycylcycline, cephalosporin, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification26 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ acrA
Publications

Pakzad I, et al. 2013. GMS Hyg Infect Control 8(2):Doc15 Contribution of AcrAB efflux pump to ciprofloxacin resistance in Klebsiella pneumoniae isolated from burn patients. (PMID 24327941)

Padilla E, et al. 2010. Antimicrob. Agents Chemother. 54(1):177-83 Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence. (PMID 19858254)

Resistomes

Prevalence of Klebsiella pneumoniae acrA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 770


>gb|CAC41008.1|+|Klebsiella pneumoniae acrA [Klebsiella pneumoniae]
MNKNRGLTPLAVVLMLSGSLALTGCDDKPAQQGAQHMPEVGIVTLKSAPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFVEGSDIQAG
VFLYQIDPATYQGSYDSAKGDLAKAQAAANMDQLTVKRYQKLLGTQYISQQDYDPAVATAQQNNAAVVAAKTAVETARINLAYTQKSPLR
SAAGSGKSPVTEGALVQNGQTTALATVQQVDPIYVDVTQSSNDFLRLKQELADARLKQENGKAKVELVTNDGLKYPQSGTLEFSDVTVDQ
TTGSITLRAIFPNPDHTLLPGMFVRARLEEGINPDALLVPQQGVTRTPRGDASVMVVGEGDKVEVRQVTASQAIGDKWLVTDGLKSGDRV
IVTGLQKIKPGVQVKAQEVASDDKQQAAGNAPSEQTKS


>gb|AJ318073.1|+|794-1990|Klebsiella pneumoniae acrA [Klebsiella pneumoniae]
ATGAACAAAAACAGAGGGTTAACGCCTCTGGCGGTCGTTCTGATGCTCTCAGGCAGCTTAGCGCTAACAGGATGTGACGATAAACCGGCT
CAACAGGGAGCCCAGCACATGCCGGAAGTCGGTATTGTGACGCTCAAATCCGCACCTCTACAAATAACCACCGAACTGCCAGGCCGCACC
AGCGCCTATCGCATTGCGGAAGTCCGTCCTCAGGTCAGTGGCATTATTTTAAAACGTAACTTCGTGGAAGGTAGCGATATCCAGGCCGGC
GTCTTCCTGTATCAGATCGATCCAGCCACCTATCAAGGCAGCTATGACAGCGCCAAAGGCGACCTGGCAAAAGCCCAGGCGGCGGCAAAC
ATGGATCAACTGACGGTCAAGCGTTATCAGAAACTGTTGGGCACCCAATATATTAGTCAACAAGACTACGATCCCGCCGTTGCGACGGCG
CAACAAAACAATGCCGCCGTGGTCGCGGCGAAAACTGCCGTTGAAACCGCGCGCATCAATTTGGCCTACACCCAAAAGTCACCTCTCCGA
TCAGCGGCCGGATCGGGTAAATCCCCCGTGACCGAAGGGGCGTTGGTACAGAATGGTCAAACGACCGCCTTGGCAACCGTTCAGCAAGTG
GATCCGATCTATGTTGACGTCACCCAGTCGAGCAATGATTTCCTGCGCCTGAAGCAGGAGCTAGCCGACGCCCGCCTGAAACAGGAAAAC
GGCAAAGCGAAAGTGGAGCTGGTGACTAATGACGGGCTTAAGTATCCGCAGTCCGGCACGCTGGAATTCTCGGATGTCACCGTCGATCAG
ACCACCGGCTCAATCACGCTACGCGCTATTTTCCCGAACCCGGATCACACCCTGCTTCCGGGGATGTTCGTCCGTGCCCGTCTGGAAGAA
GGGATTAACCCTGACGCCCTGCTGGTACCGCAACAGGGTGTTACCCGTACGCCGCGCGGCGACGCCAGCGTCATGGTAGTGGGTGAAGGC
GATAAAGTCGAAGTCCGCCAGGTCACTGCTTCTCAGGCGATCGGCGATAAATGGCTGGTCACTGACGGTCTGAAATCCGGCGATCGCGTT
ATCGTCACCGGCCTGCAAAAAATCAAACCAGGTGTGCAGGTAAAAGCGCAGGAAGTAGCTTCTGATGATAAACAGCAAGCCGCAGGCAAC
GCGCCATCAGAACAAACCAAGTCTTAA