Accession ARO:3000827
DefinitionSoxRS is a two-component regulator part of the superoxide stress response. It is a positive regulator for many multidrug efflux pumps.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump, ATP-binding cassette (ABC) antibiotic efflux pump, major facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, fluoroquinolone antibiotic, phenicol antibiotic, penam, glycylcycline, disinfecting agents and antiseptics, cephalosporin, rifamycin antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification28 ontology terms | Show
Parent Term(s)4 ontology terms | Show
2 ontology terms | Show
+ soxR part_of
+ soxS part_of

Miller PF, et al. 1994. Antimicrob Agents Chemother 38(8): 1773-1779. Genetic relationship between soxRS and mar loci in promoting multiple antibiotic resistance in Escherichia coli. (PMID 7986007)