Accession ARO:3000836
DefinitionSoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps. In Pseudomonas aeruginosa, which lacks SoxS, SoxR is able to directly upregulate the expression of the MexGHI-OpmD efflux pump.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump, resistance-nodulation-cell division (RND) antibiotic efflux pump, ATP-binding cassette (ABC) antibiotic efflux pump
Drug Classtetracycline antibiotic, glycylcycline, fluoroquinolone antibiotic, penam, phenicol antibiotic, cephalosporin, rifamycin antibiotic, disinfecting agents and antiseptics
Resistance Mechanismantibiotic efflux, antibiotic target alteration
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification35 ontology terms | Show
Parent Term(s)2 ontology terms | Show
3 ontology terms | Show

Palma M, et al. 2005. Infect Immun 73(5): 2958-2966. Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response. (PMID 15845502)

Gu M and Imlay JA. 2011. Mol Microbiol 79(5): 1136-1150. The SoxRS response of Escherichia coli is directly activated by redox-cycling drugs rather than by superoxide. (PMID 21226770)