soxR

Ontology

CARD's Antibiotic Resistance Ontology

Accession

ARO:3000836

Definition

SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps. In Pseudomonas aeruginosa, which lacks SoxS, SoxR is able to directly upregulate the expression of the MexGHI-OpmD efflux pump.

AMR Gene Family

resistance-nodulation-cell division (RND) antibiotic efflux pump, major facilitator superfamily (MFS) antibiotic efflux pump, ATP-binding cassette (ABC) antibiotic efflux pump, antibiotic efflux regulatory protein

Drug Class

tetracycline antibiotic, penicillin beta-lactam, cephalosporin, disinfecting agents and antiseptics, phenicol antibiotic, rifamycin antibiotic, glycylcycline, fluoroquinolone antibiotic

Resistance Mechanism

antibiotic efflux, antibiotic target alteration

Efflux Component

efflux pump complex or subunit conferring antibiotic resistance

Efflux Regulator

protein(s) or two-component regulatory system modulating antibiotic efflux

CARD:Epi text mining of PubMed up to 2021

(top ten associations if supported by more than one publication)

NCBI_TAXON	Escherichia coli (8), Salmonella (4), Salmonella enterica (4), Enterobacter cloacae (2)
GAZ
FOODON
ENVO
UBERON

Classification

37 ontology terms | Show

+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ beta-lactam antibiotic
+ mechanism of antibiotic resistance
+ tetracycline antibiotic [Drug Class]
+ penicillin beta-lactam [Drug Class]
+ determinant of antibiotic resistance
+ antibiotic efflux [Resistance Mechanism]
+ cephalosporin [Drug Class]
+ penicillin with extended spectrum
+ first-generation cephalosporin [Drug Subclass]
+ disinfecting agents and antiseptics [Drug Class]
+ phenicol antibiotic [Drug Class]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ rifamycin antibiotic [Drug Class]
+ antibiotic target alteration [Resistance Mechanism]
+ glycylcycline [Drug Class]
+ fluoroquinolone antibiotic [Drug Class]
+ triclosan [Antibiotic]
+ cefalotin [Antibiotic]
+ norfloxacin [Antibiotic]
+ ampicillin [Antibiotic]
+ protein(s) or two-component regulatory system modulating antibiotic efflux [Efflux Regulator]
+ chloramphenicol [Antibiotic]
+ mutation conferring antibiotic resistance
+ rifampin [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family]
+ tetracycline [Antibiotic]
+ ciprofloxacin [Antibiotic]
+ tigecycline [Antibiotic]
+ antibiotic efflux regulatory protein [AMR Gene Family]
+ PatA-PatB
+ QepA1
+ AcrAB-TolC
+ antibiotic resistance gene variant or mutant

Parent Term(s)

2 ontology terms | Show

+ mutant efflux regulatory protein conferring antibiotic resistance
+ part_of soxRS

Sub-Term(s)

3 ontology terms | Show

+ Escherichia coli soxR with mutation conferring antibiotic resistance
+ Salmonella enterica soxR with mutation conferring antibiotic resistance
+ Pseudomonas aeruginosa soxR

Publications

Palma M, et al. 2005. Infect Immun 73(5): 2958-2966. Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response. (PMID 15845502)

Gu M and Imlay JA. 2011. Mol Microbiol 79(5): 1136-1150. The SoxRS response of Escherichia coli is directly activated by redox-cycling drugs rather than by superoxide. (PMID 21226770)

Curator Acknowledgements

Curator	Description	Most Recent Edit

soxR

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