soxS

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3000837
DefinitionSoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump, major facilitator superfamily (MFS) antibiotic efflux pump, ATP-binding cassette (ABC) antibiotic efflux pump, antibiotic efflux regulatory protein, General Bacterial Porin with reduced permeability to beta-lactams
Drug Classtetracycline antibiotic, penicillin beta-lactam, cephalosporin, disinfecting agents and antiseptics, phenicol antibiotic, rifamycin antibiotic, glycylcycline, fluoroquinolone antibiotic, carbapenem, monobactam
Resistance Mechanismreduced permeability to antibiotic, antibiotic efflux, antibiotic target alteration
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) or two-component regulatory system modulating antibiotic efflux
CARD:Epi text mining of PubMed up to 2021

(top ten associations if supported by more than one publication)
NCBI_TAXONEscherichia coli (21), Salmonella (9), Salmonella enterica (4), Klebsiella pneumoniae (3), Enterobacter cloacae (2), Salmonella enterica subsp. enterica serovar Typhimurium str. DT104 (2)
GAZ
FOODON
ENVO
UBERONmembrane organ (4)
Classification43 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ beta-lactam antibiotic
+ mechanism of antibiotic resistance
+ reduced permeability to antibiotic [Resistance Mechanism]
+ tetracycline antibiotic [Drug Class]
+ penicillin beta-lactam [Drug Class]
+ determinant of antibiotic resistance
+ antibiotic efflux [Resistance Mechanism]
+ cephalosporin [Drug Class]
+ penicillin with extended spectrum
+ first-generation cephalosporin [Drug Subclass]
+ disinfecting agents and antiseptics [Drug Class]
+ phenicol antibiotic [Drug Class]
+ protein modulating permeability to antibiotic
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ rifamycin antibiotic [Drug Class]
+ antibiotic target alteration [Resistance Mechanism]
+ glycylcycline [Drug Class]
+ fluoroquinolone antibiotic [Drug Class]
+ General Bacterial Porin (GBP)
+ triclosan [Antibiotic]
+ cefalotin [Antibiotic]
+ norfloxacin [Antibiotic]
+ ampicillin [Antibiotic]
+ protein(s) or two-component regulatory system modulating antibiotic efflux [Efflux Regulator]
+ chloramphenicol [Antibiotic]
+ mutation conferring antibiotic resistance
+ rifampin [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family]
+ tetracycline [Antibiotic]
+ ciprofloxacin [Antibiotic]
+ tigecycline [Antibiotic]
+ carbapenem [Drug Class]
+ monobactam [Drug Class]
+ antibiotic efflux regulatory protein [AMR Gene Family]
+ General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family]
+ PatA-PatB
+ QepA1
+ AcrAB-TolC
+ antibiotic resistance gene variant or mutant
Parent Term(s)3 ontology terms | Show
Sub-Term(s)
2 ontology terms | Show
Publications

Ma D, et al. 1996. Mol Microbiol 19(1): 101-112. The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals. (PMID 8821940)

Palma M, et al. 2005. Infect Immun 73(5): 2958-2966. Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response. (PMID 15845502)

White DG, et al. 1997. J Bacteriol 179(19): 6122-6126. Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli. (PMID 9324261)

Miller PF, et al. 1994. Antimicrob Agents Chemother 38(8): 1773-1779. Genetic relationship between soxRS and mar loci in promoting multiple antibiotic resistance in Escherichia coli. (PMID 7986007)
Curator Acknowledgements
Curator Description Most Recent Edit