soxS

Accession ARO:3000837
DefinitionSoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump, major facilitator superfamily (MFS) antibiotic efflux pump, resistance-nodulation-cell division (RND) antibiotic efflux pump, General Bacterial Porin with reduced permeability to beta-lactams
Drug Classtetracycline antibiotic, phenicol antibiotic, cephalosporin, fluoroquinolone antibiotic, penam, rifamycin antibiotic, glycylcycline, disinfecting agents and antiseptics, cephamycin, monobactam, penem, carbapenem
Resistance Mechanismreduced permeability to antibiotic, antibiotic efflux, antibiotic target alteration
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification43 ontology terms | Show
+ process or component of antibiotic biology or chemistry
+ antibiotic molecule
+ mechanism of antibiotic resistance
+ beta-lactam antibiotic
+ determinant of antibiotic resistance
+ tetracycline antibiotic [Drug Class]
+ cephem
+ reduced permeability to antibiotic [Resistance Mechanism]
+ antibiotic efflux [Resistance Mechanism]
+ phenicol antibiotic [Drug Class]
+ antibiotic target alteration [Resistance Mechanism]
+ cephalosporin [Drug Class]
+ fluoroquinolone antibiotic [Drug Class]
+ protein modulating permeability to antibiotic
+ penam [Drug Class]
+ rifamycin antibiotic [Drug Class]
+ glycylcycline [Drug Class]
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ disinfecting agents and antiseptics [Drug Class]
+ cefalotin [Antibiotic]
+ cephamycin [Drug Class]
+ mutation conferring antibiotic resistance
+ ciprofloxacin [Antibiotic]
+ norfloxacin [Antibiotic]
+ ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family]
+ monobactam [Drug Class]
+ tigecycline [Antibiotic]
+ ampicillin [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ triclosan [Antibiotic]
+ General Bacterial Porin (GBP)
+ rifampin [Antibiotic]
+ penem [Drug Class]
+ tetracycline [Antibiotic]
+ carbapenem [Drug Class]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ chloramphenicol [Antibiotic]
+ protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator]
+ PatA-PatB
+ antibiotic resistant gene variant or mutant
+ AcrAB-TolC
+ General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family]
+ QepA1
Parent Term(s)3 ontology terms | Show
Sub-Term(s)
2 ontology terms | Show
Publications

Ma D, et al. 1996. Mol Microbiol 19(1): 101-112. The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals. (PMID 8821940)

Palma M, et al. 2005. Infect Immun 73(5): 2958-2966. Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response. (PMID 15845502)

White DG, et al. 1997. J Bacteriol 179(19): 6122-6126. Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli. (PMID 9324261)

Miller PF, et al. 1994. Antimicrob Agents Chemother 38(8): 1773-1779. Genetic relationship between soxRS and mar loci in promoting multiple antibiotic resistance in Escherichia coli. (PMID 7986007)