porin OmpF

Accession ARO:3000265
DefinitionIn the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF.
AMR Gene FamilyGeneral Bacterial Porin with reduced permeability to beta-lactams
Drug Classmonobactam, cephamycin, penem, carbapenem, penam, cephalosporin
Resistance Mechanismreduced permeability to antibiotic
Classification15 ontology terms | Show
Parent Term(s)1 ontology terms | Show
4 ontology terms | Show

Cohen SP, et al. 1988. J Bacteriol 170(12): 5416-5422. marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coli. (PMID 2848006)

Delcour AH. 2009. Biochim Biophys Acta 1794(5): 808-816. Outer membrane permeability and antibiotic resistance. (PMID 19100346)