sdiA

Accession ARO:3000826
CARD Short NamesdiA
DefinitionSdiA is a cell division regulator that is also a positive regulator of AcrAB only when it's expressed from a plasmid. When the sdiA gene is on the chromosome, it has no effect on expression of acrAB.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, penicillin beta-lactam, cephalosporin, disinfecting agents and antiseptics, phenicol antibiotic, rifamycin antibiotic, glycylcycline, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Resistomes with Perfect MatchesSalmonella entericag+wgs
Resistomes with Sequence VariantsSalmonella entericag+p+wgs
Classification25 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Rahmati S, et al. 2002. Mol Microbiol 43(3): 677-685. Control of the AcrAB multidrug efflux pump by quorum-sensing regulator SdiA. (PMID 11929524)

Dyszel JL, et al. 2010. PLoS One 5(1): E8946. E. coli K-12 and EHEC genes regulated by SdiA. (PMID 20126629)

Resistomes

Prevalence of sdiA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Salmonella enterica94.26%0.05%98.4%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 470


>gb|AAL20862.1|-|sdiA [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MQENDFFTWRRAMLLRFQEMAAAEDVYTELQYQTQRLEFDYYALCVRHPVPFTRPKISLRTTYPPAWVTHYQSENYFAIDPVLKPENFRQ
GHLHWDDVLFHEAKAMWDAAQRFGLRRGVTQCVMLPNRALGFLSFSRSSLRCSSFTYDEVELRLQLLARESLSALTRFEDDMVMAPEMRF
SKREKEILKWTAEGKTSSEIAIILSISENTVNFHQKNMQKKFNAPNKTQIACYAAATGLI


>gb|AE006468.2|-|2039655-2040377|sdiA [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGCAGGAAAATGATTTCTTCACCTGGCGACGCGCAATGTTGTTACGCTTTCAGGAGATGGCGGCAGCAGAGGATGTTTATACTGAATTG
CAATATCAGACACAGCGGCTGGAATTTGATTATTATGCCCTGTGTGTTCGTCATCCCGTCCCCTTTACCCGGCCTAAAATATCGCTTCGT
ACCACTTATCCTCCGGCGTGGGTAACGCATTACCAGTCCGAAAACTATTTCGCGATCGATCCGGTATTAAAGCCGGAAAATTTCAGGCAG
GGTCATTTACATTGGGATGACGTGCTATTTCATGAAGCGAAGGCGATGTGGGATGCCGCCCAGCGTTTCGGATTACGCAGAGGCGTAACC
CAGTGTGTGATGTTGCCGAACCGGGCGCTGGGCTTTTTATCTTTCTCCCGTAGCAGTTTACGCTGCTCCTCGTTTACCTACGACGAAGTG
GAGCTGAGGTTGCAACTGCTGGCGCGGGAGAGTCTTTCGGCGCTGACAAGATTTGAAGACGACATGGTGATGGCGCCTGAAATGCGTTTC
AGTAAACGTGAGAAAGAGATTCTGAAGTGGACGGCGGAAGGGAAGACCTCATCGGAGATCGCCATTATTCTGTCGATTTCTGAAAATACC
GTTAACTTCCATCAGAAAAATATGCAGAAGAAATTCAATGCGCCAAATAAAACACAGATTGCCTGCTACGCTGCGGCGACAGGTCTGATA
TGA

Curator Acknowledgements
Curator Description Most Recent Edit