| Accession | ARO:3002846 |
| CARD Short Name | arr-1 |
| Definition | arr-1 is a chromosome-encoded ribosyltransferase found in Mycolicibacterium smegmatis. |
| AMR Gene Family | rifampin ADP-ribosyltransferase (Arr) |
| Drug Class | rifamycin antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Mycolicibacterium fortuitumg+wgs, Mycolicibacterium septicumg+wgs |
| Classification | 13 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + rifamycin antibiotic [Drug Class] + rifampin inactivation enzyme + rifapentine [Antibiotic] + rifabutin [Antibiotic] + rifaximin [Antibiotic] + ADP-ribosylation of antibiotic conferring resistance + rifampin [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic rifampin [Antibiotic] + rifampin ADP-ribosyltransferase (Arr) [AMR Gene Family] |
| Publications | Quan S, et al. 1997. Antimicrob Agents Chemother 41(11): 2456-2460. Ribosylative inactivation of rifampin by Mycobacterium smegmatis is a principal contributor to its low susceptibility to this antibiotic. (PMID 9371349) |
Prevalence of arr-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Mycolicibacterium fortuitum | 100% | 0% | 89.66% | 0% |
| Mycolicibacterium septicum | 100% | 0% | 100% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 250