rifaximin [Antibiotic]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3000517
DefinitionRifaximin is a semi-synthetic rifamycin used to treat traveller's diarrhea. Rifaximin inhibits RNA synthesis by binding to the beta subunit of bacterial RNA polymerase.
SMILESCO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C
PubChem6436173
ChEMBLCHEMBL1617
ChEBI75246
CAS80621-81-4
Drug Classrifamycin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ rifamycin antibiotic [Drug Class]
Sub-Term(s)
17 ontology terms | Show
+ rifampin ADP-ribosyltransferase (Arr) [AMR Gene Family] confers_resistance_to_antibiotic
+ DnaA confers_resistance_to_antibiotic
+ RbpA confers_resistance_to_antibiotic
+ rpoB2 confers_resistance_to_antibiotic
+ sigma factor conferring resistance to rifampin confers_resistance_to_antibiotic
+ Escherichia coli rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Mycobacterium leprae rpoB mutations conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Staphylococcus aureus rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic
+ rgt1438 confers_resistance_to_antibiotic
+ iri confers_resistance_to_antibiotic
+ rphB confers_resistance_to_antibiotic
+ rphA confers_resistance_to_antibiotic
+ Clostridioides difficile rpoB with mutation conferring resistance to rifampicin confers_resistance_to_antibiotic
+ HelR confers_resistance_to_antibiotic
+ Streptomyces venezuelae rox confers_resistance_to_antibiotic
+ rifamycin sensitive beta-subunit of RNA polymerase (rpoB) targeted_by_antibiotic
Publications

Huang DB and DuPont HL. 2005. J Infect 50(2): 97-106. Rifaximin--a novel antimicrobial for enteric infections. (PMID 15667909)

Curator Acknowledgements
Curator Description Most Recent Edit