| Accession | ARO:3000248 |
| CARD Short Name | DnaA |
| Definition | DnaA is a chromosomal replication initiation protein which binds and interacts with RNA polymerase in Escherichia coli. A surplus of DnaA present in a cell has been shown to confer resistance to the antibiotic Rifampicin. Normally, rifampicin inhibits initiation of transcription by RNA polymerase, but a surplus of DnaA available at the origin has been shown to disrupt Rifampicin activity and confer resistance. |
| AMR Gene Family | DnaA chromosomal replication initiation protein |
| Drug Class | rifamycin antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target protection [Resistance Mechanism] + antibiotic target protection protein + antibiotic molecule + rifampin-resistant RNA polymerase-binding protein + rifamycin antibiotic [Drug Class] |
| Parent Term(s) | 5 ontology terms | Show + confers_resistance_to_antibiotic rifampin [Antibiotic] + confers_resistance_to_antibiotic rifaximin [Antibiotic] + confers_resistance_to_antibiotic rifabutin [Antibiotic] + confers_resistance_to_antibiotic rifapentine [Antibiotic] + DnaA chromosomal replication initiation protein [AMR Gene Family] |
| Publications | Flatten I, et al. 2009. Mol Microbiol 71(4): 1018-1030. DnaA protein interacts with RNA polymerase and partially protects it from the effect of rifampicin. (PMID 19170875) |
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