Accession ARO:3000248
CARD Short NameDnaA
DefinitionDnaA is a chromosomal replication initiation protein which binds and interacts with RNA polymerase in Escherichia coli. A surplus of DnaA present in a cell has been shown to confer resistance to the antibiotic Rifampicin. Normally, rifampicin inhibits initiation of transcription by RNA polymerase, but a surplus of DnaA available at the origin has been shown to disrupt Rifampicin activity and confer resistance.
AMR Gene FamilyDnaA chromosomal replication initiation protein
Drug Classrifamycin antibiotic
Resistance Mechanismantibiotic target protection
Classification8 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_antibiotic rifabutin [Antibiotic]
+ confers_resistance_to_antibiotic rifampin [Antibiotic]
+ confers_resistance_to_antibiotic rifapentine [Antibiotic]
+ confers_resistance_to_antibiotic rifaximin [Antibiotic]
+ DnaA chromosomal replication initiation protein [AMR Gene Family]

Flatten I, et al. 2009. Mol Microbiol 71(4): 1018-1030. DnaA protein interacts with RNA polymerase and partially protects it from the effect of rifampicin. (PMID 19170875)

Private model - RGI is not currently using this model.