Accession ARO:3003947
DefinitionEfrAB is a heterodimeric ABC transporter efflux pump found in Enterococcus faecalis and Enterococcus faecium that confers resistance to ciprofloxacin, erythromycin, rifampicin, quinupristine.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump
Drug Classfluoroquinolone antibiotic, macrolide antibiotic, rifamycin antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification9 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic rifampin [Antibiotic]
2 ontology terms | Show
+ efrA part_of
+ efrB part_of

Lavilla Lerma L, et al. 2014. Food Microbiol. 44:249-57 Role of EfrAB efflux pump in biocide tolerance and antibiotic resistance of Enterococcus faecalis and Enterococcus faecium isolated from traditional fermented foods and the effect of EDTA as EfrAB inhibitor. (PMID 25084670)

Lee EW, et al. 2003. Antimicrob Agents Chemother 47(12): 3733-3738. EfrAB, an ABC multidrug efflux pump in Enterococcus faecalis. (PMID 14638474)