| Accession | ARO:3003949 |
| CARD Short Name | efrB |
| Definition | efrB is a part of the EfrAB efflux pump, and both efrA and efrB are necessary to confer multidrug resistance. |
| AMR Gene Family | ATP-binding cassette (ABC) antibiotic efflux pump |
| Drug Class | macrolide antibiotic, rifamycin antibiotic, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 13 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + antibiotic molecule + determinant of antibiotic resistance + macrolide antibiotic [Drug Class] + rifamycin antibiotic [Drug Class] + fluoroquinolone antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + ciprofloxacin [Antibiotic] + rifampin [Antibiotic] + erythromycin [Antibiotic] + ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Lee EW, et al. 2003. Antimicrob Agents Chemother 47(12): 3733-3738. EfrAB, an ABC multidrug efflux pump in Enterococcus faecalis. (PMID 14638474) Lavilla Lerma L, et al. 2014. Food Microbiol. 44:249-57 Role of EfrAB efflux pump in biocide tolerance and antibiotic resistance of Enterococcus faecalis and Enterococcus faecium isolated from traditional fermented foods and the effect of EDTA as EfrAB inhibitor. (PMID 25084670) |
Prevalence of efrB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 710