daptomycin resistant beta-subunit of RNA polymerase (rpoB) [AMR Gene Family]

Accession ARO:3003090
DefinitionDaptomycin resistant RNA polymerases include amino acids substitutions which alter expression of the dlt operon, which increases the cell surface positive charge. Known from S. aureus.
Drug Classpeptide antibiotic, rifamycin antibiotic
Resistance Mechanismantibiotic target alteration
Classification9 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_antibiotic daptomycin [Antibiotic]
+ antibiotic resistant rpoB
+ derives_from daptomycin sensitive beta-subunit of RNA polymerase (rpoB)
+ confers_resistance_to_drug_class rifamycin antibiotic [Drug Class]
+ confers_resistance_to_drug_class peptide antibiotic [Drug Class]
1 ontology terms | Show

Cui L, et al. 2010. Antimicrob Agents Chemother 54(12): 5222-5233. An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus. (PMID 20837752)