| Accession | ARO:3003090 |
| Definition | Daptomycin resistant RNA polymerases include amino acids substitutions which alter expression of the dlt operon, which increases the cell surface positive charge. Known from S. aureus. |
| Drug Class | peptide antibiotic, rifamycin antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic target alteration [Resistance Mechanism] + determinant of antibiotic resistance + mutation conferring antibiotic resistance + peptide antibiotic [Drug Class] + lipopeptide antibiotic + antibiotic resistant gene variant or mutant |
| Parent Term(s) | 5 ontology terms | Show + confers_resistance_to_antibiotic daptomycin [Antibiotic] + antibiotic resistant rpoB + derives_from daptomycin sensitive beta-subunit of RNA polymerase (rpoB) + confers_resistance_to_drug_class rifamycin antibiotic [Drug Class] + confers_resistance_to_drug_class peptide antibiotic [Drug Class] |
| Sub-Term(s) | 1 ontology terms | Show |
| Publications | Cui L, et al. 2010. Antimicrob Agents Chemother 54(12): 5222-5233. An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus. (PMID 20837752) |