| Accession | ARO:0000068 |
| Synonym(s) | Cidecin Cubicin Daptomicina Daptomycine Daptomycinum Deptomycin |
| Definition | Daptomycin is a novel lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. Daptomycin interferes with the bacterial cell membrane, reducing membrane potential and inhibiting cell wall synthesis. |
| Drug Class | peptide antibiotic |
| Classification | 3 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 39 ontology terms | Show + Staphylococcus aureus cls conferring resistance to daptomycin confers_resistance_to_antibiotic + daptomycin resistant beta-subunit of RNA polymerase (rpoB) [AMR Gene Family] confers_resistance_to_antibiotic + Enterococcus faecium cls conferring resistance to daptomycin confers_resistance_to_antibiotic + Staphylococcus aureus mprF with mutation conferring resistance to daptomycin confers_resistance_to_antibiotic + Staphylococcus aureus pgsA mutations conferring resistance to daptomycin confers_resistance_to_antibiotic + Staphylococcus aureus rpoC conferring resistance to daptomycin confers_resistance_to_antibiotic + Enterococcus faecalis cls with mutation conferring resistance to daptomycin confers_resistance_to_antibiotic + Bacillus subtilis pgsA with mutation conferring resistance to daptomycin confers_resistance_to_antibiotic + Enterococcus faecium liaF mutant conferring daptomycin resistance confers_resistance_to_antibiotic + Enterococcus faecalis liaF mutant conferring daptomycin resistance confers_resistance_to_antibiotic + Enterococcus faecium liaR mutant conferring daptomycin resistance confers_resistance_to_antibiotic + Enterococcus faecium liaS mutant conferring daptomycin resistance confers_resistance_to_antibiotic + Enterococcus faecalis liaS mutant conferring daptomycin resistance confers_resistance_to_antibiotic + Enterococcus faecalis liaR mutant conferring daptomycin resistance confers_resistance_to_antibiotic + Staphylococcus aureus walK with mutation conferring resistance to daptomycin confers_resistance_to_antibiotic + Enterococcus faecalis YybT with mutation conferring daptomycin resistance confers_resistance_to_antibiotic + Enterococcus faecalis gdpD with mutation conferring daptomycin resistance confers_resistance_to_antibiotic + Staphylococcus aureus agrA with mutation conferring resistance to daptomycin confers_resistance_to_antibiotic + Enterococcus faecalis gshF with mutation conferring daptomycin resistance confers_resistance_to_antibiotic + Enterococcus faecalis drmA with mutation conferring daptomycin resistance confers_resistance_to_antibiotic + Enterococcus faecalis YvlB with mutation conferring daptomycin resistance confers_resistance_to_antibiotic + abcA confers_resistance_to_antibiotic + Streptococcus mitis CdsA with mutation conferring daptomycin resistance confers_resistance_to_antibiotic + daptomycin resistant pgsA [AMR Gene Family] confers_resistance_to_antibiotic + daptomycin resistant cls [AMR Gene Family] confers_resistance_to_antibiotic + daptomycin resistant walK [AMR Gene Family] confers_resistance_to_antibiotic + daptomycin resistant YybT [AMR Gene Family] confers_resistance_to_antibiotic + daptomycin resistant gdpD [AMR Gene Family] confers_resistance_to_antibiotic + daptomycin resistant agrA [AMR Gene Family] confers_resistance_to_antibiotic + daptomycin resistant drmA [AMR Gene Family] confers_resistance_to_antibiotic + daptomycin resistant YvlB [AMR Gene Family] confers_resistance_to_antibiotic + daptomycin resistant CdsA [AMR Gene Family] confers_resistance_to_antibiotic + daptomycin resistant mprF [AMR Gene Family] confers_resistance_to_antibiotic + daptomycin-resistant beta prime subunit of RNA polymerase (rpoC) [AMR Gene Family] confers_resistance_to_antibiotic + Staphylococcus aureus rpoB mutants conferring resistance to daptomycin confers_resistance_to_antibiotic + Daptomycin sensitive cardiolipin synthetase targeted_by_antibiotic + daptomycin sensitive beta-subunit of RNA polymerase (rpoB) targeted_by_antibiotic + antibiotic sensitive mprF targeted_by_antibiotic + antibiotic sensitive pgsA targeted_by_antibiotic |
| Publications | Miao V, et al. 2005. Microbiology 151(PT 5): 1507-1523. Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry. (PMID 15870461) Critchley IA, et al. 2003. J Antimicrob Chemother 51(3): 639-649. Activity of daptomycin against susceptible and multidrug-resistant Gram-positive pathogens collected in the SECURE study (Europe) during 2000-2001. (PMID 12615866) Barry AL, et al. 2001. Antimicrob Agents Chemother 45(6): 1919-1922. In vitro activities of daptomycin against 2,789 clinical isolates from 11 North American medical centers. (PMID 11353654) Robbel L and Marahiel MA. 2010. J Biol Chem 285(36): 27501-27508. Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery. (PMID 20522545) Streit JM, et al. 2004. J Antimicrob Chemother 53(4): 669-674. Daptomycin activity and spectrum: a worldwide sample of 6737 clinical Gram-positive organisms. (PMID 14985278) Baltz RH, et al. 2005. Nat Prod Rep 22(6): 717-741. Natural products to drugs: daptomycin and related lipopeptide antibiotics. (PMID 16311632) D'Costa VM, et al. 2012. Antimicrob Agents Chemother 56(2): 757-764. Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms. (PMID 22083474) |
