daptomycin [Antibiotic]

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Accession ARO:0000068
Synonym(s)Cubicin Daptomycinum Daptomycine Cidecin Deptomycin Daptomicina
DefinitionDaptomycin is a novel lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. Daptomycin interferes with the bacterial cell membrane, reducing membrane potential and inhibiting cell wall synthesis.
Drug Classpeptide antibiotic
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
43 ontology terms | Show
+ daptomycin resistant liaFSR confers_resistance_to_antibiotic
+ Staphylococcus aureus cls conferring resistance to daptomycin confers_resistance_to_antibiotic
+ daptomycin resistant beta-subunit of RNA polymerase (rpoB) [AMR Gene Family] confers_resistance_to_antibiotic
+ Enterococcus faecium cls conferring resistance to daptomycin confers_resistance_to_antibiotic
+ Staphylococcus aureus mprF with mutation conferring resistance to daptomycin confers_resistance_to_antibiotic
+ Staphylococcus aureus pgsA mutations conferring resistance to daptomycin confers_resistance_to_antibiotic
+ Staphylococcus aureus rpoC conferring resistance to daptomycin confers_resistance_to_antibiotic
+ Enterococcus faecalis cls with mutation conferring resistance to daptomycin confers_resistance_to_antibiotic
+ Bacillus subtilis pgsA with mutation conferring resistance to daptomycin confers_resistance_to_antibiotic
+ Enterococcus faecium liaF mutant conferring daptomycin resistance confers_resistance_to_antibiotic
+ Enterococcus faecalis liaF mutant conferring daptomycin resistance confers_resistance_to_antibiotic
+ Enterococcus faecium liaR mutant conferring daptomycin resistance confers_resistance_to_antibiotic
+ Enterococcus faecium liaS mutant conferring daptomycin resistance confers_resistance_to_antibiotic
+ Enterococcus faecalis liaS mutant conferring daptomycin resistance confers_resistance_to_antibiotic
+ Enterococcus faecalis liaR mutant conferring daptomycin resistance confers_resistance_to_antibiotic
+ Staphylococcus aureus walK with mutation conferring resistance to daptomycin confers_resistance_to_antibiotic
+ Enterococcus faecalis YybT with mutation conferring daptomycin resistance confers_resistance_to_antibiotic
+ Enterococcus faecalis gdpD with mutation conferring daptomycin resistance confers_resistance_to_antibiotic
+ Staphylococcus aureus agrA with mutation conferring resistance to daptomycin confers_resistance_to_antibiotic
+ Enterococcus faecalis gshF with mutation conferring daptomycin resistance confers_resistance_to_antibiotic
+ Enterococcus faecalis drmA with mutation conferring daptomycin resistance confers_resistance_to_antibiotic
+ Enterococcus faecalis YvlB with mutation conferring daptomycin resistance confers_resistance_to_antibiotic
+ abcA confers_resistance_to_antibiotic
+ Streptococcus mitis CdsA with mutation conferring daptomycin resistance confers_resistance_to_antibiotic
+ daptomycin resistant pgsA [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin resistant cls [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin resistant walK [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin resistant YybT [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin resistant gdpD [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin resistant agrA [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin resistant drmA [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin resistant YvlB [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin resistant CdsA [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin resistant mprF [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin resistant liaS [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin resistant liaR [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin resistant liaF [AMR Gene Family] confers_resistance_to_antibiotic
+ daptomycin-resistant beta prime subunit of RNA polymerase (rpoC) [AMR Gene Family] confers_resistance_to_antibiotic
+ Daptomycin sensitive cardiolipin synthetase targeted_by_antibiotic
+ daptomycin sensitive beta-subunit of RNA polymerase (rpoB) targeted_by_antibiotic
+ antibiotic sensitive mprF targeted_by_antibiotic
+ antibiotic sensitive pgsA targeted_by_antibiotic
+ Staphylococcus aureus rpoB mutants conferring resistance to daptomycin targeted_by_antibiotic
Publications

Miao V, et al. 2005. Microbiology 151(PT 5): 1507-1523. Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry. (PMID 15870461)

Critchley IA, et al. 2003. J Antimicrob Chemother 51(3): 639-649. Activity of daptomycin against susceptible and multidrug-resistant Gram-positive pathogens collected in the SECURE study (Europe) during 2000-2001. (PMID 12615866)

Barry AL, et al. 2001. Antimicrob Agents Chemother 45(6): 1919-1922. In vitro activities of daptomycin against 2,789 clinical isolates from 11 North American medical centers. (PMID 11353654)

Robbel L and Marahiel MA. 2010. J Biol Chem 285(36): 27501-27508. Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery. (PMID 20522545)

Streit JM, et al. 2004. J Antimicrob Chemother 53(4): 669-674. Daptomycin activity and spectrum: a worldwide sample of 6737 clinical Gram-positive organisms. (PMID 14985278)

Baltz RH, et al. 2005. Nat Prod Rep 22(6): 717-741. Natural products to drugs: daptomycin and related lipopeptide antibiotics. (PMID 16311632)

D'Costa VM, et al. 2012. Antimicrob Agents Chemother 56(2): 757-764. Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms. (PMID 22083474)