daptomycin resistant pgsA [AMR Gene Family]

Accession ARO:3003080
Synonym(s)phosphatidylglycerophosphate synthetase
DefinitionpgsA or phosphatidylglycerophosphate synthetase is an integral membrane protein involved in phospholipid biosynthesis. It is a CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase. Laboratory experiments have detected mutations conferring daptomycin resistance in Entercoccus.
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification9 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic daptomycin [Antibiotic]
+ confers_resistance_to_drug_class peptide antibiotic [Drug Class]
+ determinant of resistance to lipopeptide antibiotics
+ antibiotic resistant pgsA
2 ontology terms | Show

Peleg AY, et al. 2012. PLoS One 7(1): E28316. Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus. (PMID 22238576)

Hachmann AB, et al. 2011. Antimicrob Agents Chemother 55(9): 4326-4337. Reduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis. (PMID 21709092)