| Accession | ARO:3003272 |
| Synonym(s) | cardiolipin synthetase |
| Definition | Cardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Current known mutations on the enzyme confer resistance to daptomycin. |
| Drug Class | peptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + peptide antibiotic [Drug Class] + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + lipopeptide antibiotic + determinant of antibiotic resistance |
| Parent Term(s) | 4 ontology terms | Show + antibiotic resistant gene variant or mutant + confers_resistance_to_antibiotic daptomycin [Antibiotic] + confers_resistance_to_drug_class peptide antibiotic [Drug Class] + derives_from antibiotic sensitive cls |
| Sub-Term(s) | 3 ontology terms | Show |
| Publications | Davlieva M, et al. 2012. Antimicrob Agents Chemother 57(1): 289-296. Biochemical characterization of cardiolipin synthase mutations associated with daptomycin resistance in enterococci. (PMID 23114777) Tropp BE and Tropp BE. 1997. Biochim Biophys Acta 1348(1-2): 192-200. Cardiolipin synthase from Escherichia coli. (PMID 9370333) |