daptomycin resistant cls [AMR Gene Family]

Accession ARO:3003272
Synonym(s)cardiolipin synthetase
DefinitionCardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Current known mutations on the enzyme confer resistance to daptomycin.
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification8 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ antibiotic resistant gene variant or mutant
+ derives_from antibiotic sensitive cls
+ confers_resistance_to_antibiotic daptomycin [Antibiotic]
+ confers_resistance_to_drug_class peptide antibiotic [Drug Class]
3 ontology terms | Show

Davlieva M, et al. 2012. Antimicrob Agents Chemother 57(1): 289-296. Biochemical characterization of cardiolipin synthase mutations associated with daptomycin resistance in enterococci. (PMID 23114777)

Tropp BE and Tropp BE. 1997. Biochim Biophys Acta 1348(1-2): 192-200. Cardiolipin synthase from Escherichia coli. (PMID 9370333)