daptomycin resistant mprF [AMR Gene Family]

Accession ARO:3003091
DefinitionMprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Mutations in mprF can additionally confer resistance to daptomycin in S. aureus.
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification10 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ antibiotic resistant mprF
+ antibiotic resistant gene variant or mutant
+ derives_from antibiotic sensitive mprF
+ confers_resistance_to_antibiotic daptomycin [Antibiotic]
+ confers_resistance_to_drug_class peptide antibiotic [Drug Class]
1 ontology terms | Show

Yang SJ, et al. 2010. Antimicrob Agents Chemother 54(8): 3079-3085. Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms. (PMID 20498310)

Friedman L, et al. 2006. Antimicrob Agents Chemother 50(6): 2137-2145. Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus. (PMID 16723576)

Peleg AY, et al. 2012. PLoS One 7(1): E28316. Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus. (PMID 22238576)