| Accession | ARO:3003091 |
| Definition | MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. Mutations in mprF can additionally confer resistance to daptomycin in S. aureus. |
| Drug Class | peptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic target alteration [Resistance Mechanism] + charge alteration conferring antibiotic resistance + peptide antibiotic [Drug Class] + determinant of antibiotic resistance + gene altering cell wall charge + mutation conferring antibiotic resistance + lipopeptide antibiotic |
| Parent Term(s) | 5 ontology terms | Show + antibiotic resistant gene variant or mutant + confers_resistance_to_antibiotic daptomycin [Antibiotic] + confers_resistance_to_drug_class peptide antibiotic [Drug Class] + derives_from antibiotic sensitive mprF + antibiotic resistant mprF |
| Sub-Term(s) | 1 ontology terms | Show |
| Publications | Yang SJ, et al. 2010. Antimicrob Agents Chemother 54(8): 3079-3085. Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms. (PMID 20498310) Friedman L, et al. 2006. Antimicrob Agents Chemother 50(6): 2137-2145. Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus. (PMID 16723576) Peleg AY, et al. 2012. PLoS One 7(1): E28316. Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus. (PMID 22238576) |