antibiotic resistant mprF

Accession ARO:3003421
Synonym(s)Phosphatidylglycerol lysyltransferase
DefinitionCatalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins).
Resistance Mechanismantibiotic target alteration
Classification5 ontology terms | Show
Parent Term(s)1 ontology terms | Show
2 ontology terms | Show
+ daptomycin resistant mprF [AMR Gene Family]
+ defensin resistant mprF [AMR Gene Family]