defensin resistant mprF [AMR Gene Family]

Accession ARO:3000863
DefinitionMprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface of both Gram-positive and Gram-negative bacteria. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins.
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ antibiotic target modifying enzyme
+ antibiotic resistant mprF
+ confers_resistance_to_drug_class peptide antibiotic [Drug Class]
6 ontology terms | Show

Ernst CM, et al. 2009. PLoS Pathog 5(11): E1000660. The bacterial defensin resistance protein MprF consists of separable domains for lipid lysinylation and antimicrobial peptide repulsion. (PMID 19915718)

Yang SJ, et al. 2010. Antimicrob Agents Chemother 54(8): 3079-3085. Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms. (PMID 20498310)

Staubitz P, et al. 2004. FEMS Microbiol. Lett. 231(1):67-71 MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance. (PMID 14769468)