| Accession | ARO:3003079 |
| Synonym(s) | yvqC |
| CARD Short Name | Efac_liaS_DAP |
| Definition | liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. |
| AMR Gene Family | daptomycin resistant liaS |
| Drug Class | peptide antibiotic |
| Resistance Mechanism | antibiotic target alteration, antibiotic efflux |
| Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + antibiotic molecule + mutation conferring antibiotic resistance + peptide antibiotic [Drug Class] + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + lipopeptide antibiotic + daptomycin resistant liaFSR + antibiotic resistant gene variant or mutant |
| Parent Term(s) | 3 ontology terms | Show + antibiotic resistant liaFSR system + confers_resistance_to_antibiotic daptomycin [Antibiotic] + daptomycin resistant liaS [AMR Gene Family] |
| Publications | Arias CA, et al. 2011. N Engl J Med 365(10): 892-900. Genetic basis for in vivo daptomycin resistance in enterococci. (PMID 21899450) Munita JM, et al. 2012. Antimicrob Agents Chemother 56(8): 4354-4359. Correlation between mutations in liaFSR of Enterococcus faecium and MIC of daptomycin: revisiting daptomycin breakpoints. (PMID 22664970) |
Prevalence of Enterococcus faecium liaS mutant conferring daptomycin resistance among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein variant model
Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 650
Legend:
Published Variants:
| PMID: 21899450 | A180T |
| PMID: 22664970 | T120A E192G H264Q |