daptomycin resistant liaFSR

Accession ARO:3003076
DefinitionliaFSR is a two-component signal transduction pathway in B. subtilis that responds to peptide and lipopeptide antibiotics. The liaFSR two-component system consists of a histidine kinase liaS and the response regulator liaR as well as the accessory protein liaF, which acts as a negative regulator of liaRS-dependent signal transduction. Mutations confer resistance to daptomycin.
Resistance Mechanismantibiotic efflux
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
3 ontology terms | Show
+ daptomycin resistant liaR [AMR Gene Family] part_of
+ daptomycin resistant liaF [AMR Gene Family] part_of
+ daptomycin resistant liaS [AMR Gene Family] part_of

Arias CA, et al. 2011. N Engl J Med 365(10): 892-900. Genetic basis for in vivo daptomycin resistance in enterococci. (PMID 21899450)