daptomycin resistant YybT [AMR Gene Family]

Accession ARO:3003798
DefinitionMutations to the YybT gene confers daptomycin resistance.
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification8 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ antibiotic resistant gene variant or mutant
+ confers_resistance_to_antibiotic daptomycin [Antibiotic]
+ confers_resistance_to_drug_class peptide antibiotic [Drug Class]
1 ontology terms | Show

Miller C, et al. 2013. Antimicrob Agents Chemother 57(11): 5373-5383. Adaptation of Enterococcus faecalis to daptomycin reveals an ordered progression to resistance. (PMID 23959318)

Rao F, et al. 2010. J. Biol. Chem. 285(1):473-82 YybT is a signaling protein that contains a cyclic dinucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity. (PMID 19901023)