Daptomycin sensitive cardiolipin synthetase

Accession ARO:3003275
DefinitionCardiolipin synthetase catalyzes the formation of cardiolipin from two phosphatidylglycerol molecules. Cardiolipin is important in membrane translocation and permeabilization. Mutations on the enzyme confers resistance to Daptomycin
Classification3 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ targeted_by_antibiotic daptomycin [Antibiotic]
+ targeted_by lipopeptide antibiotic
+ antibiotic sensitive cls
2 ontology terms | Show

Arias CA, et al. 2011. N Engl J Med 365(10): 892-900. Genetic basis for in vivo daptomycin resistance in enterococci. (PMID 21899450)