daptomycin sensitive beta-subunit of RNA polymerase (rpoB)

Accession ARO:3003278
DefinitionDaptomycin binds to the cytoplasmic membrane of Gram-positive. It's lipopeptide tail servers as a ion channel for potassium. This causes a rapid depolarization that result in failures in DNA/RNA/Protein synthesis. Eventually cell death.
Classification3 ontology terms | Show
Parent Term(s)3 ontology terms | Show
1 ontology terms | Show

Cui L, et al. 2010. Antimicrob Agents Chemother 54(12): 5222-5233. An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus. (PMID 20837752)