TNP-2198 [Antibiotic]

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Accession ARO:3007176
DefinitionTNP-2198 is an experimental rifamycin-nitroimidazole conjugate currently in development for treatment of several bacterial infections. It exhibits greater activity than rifamycin and nitroimidazole antibiotics administered together and is effective against bacteria resistant to both drug classes.
Drug Classnitroimidazole antibiotic, rifamycin antibiotic
Classification2 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ nitroimidazole antibiotic [Drug Class]
+ rifamycin antibiotic [Drug Class]

Ma Z, et al. 2022. J Med Chem 65(6):4481-4495 Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. (PMID 35175750)