rifampin monooxygenase [AMR Gene Family]

Accession ARO:3000445
DefinitionEnzyme responsible for the decolorization of rifampin by monoxygenation.
Drug Classrifamycin antibiotic
Resistance Mechanismantibiotic inactivation
Classification6 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ rifampin inactivation enzyme
+ participates_in hydroxylation of antibiotic conferring resistance
+ confers_resistance_to_drug_class rifamycin antibiotic [Drug Class]
3 ontology terms | Show

Hoshino Y, et al. 2010. J Antibiot (Tokyo) 63(1): 23-28. Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance. (PMID 19942945)

Andersen SJ, et al. 1997. Antimicrob Agents Chemother 41(1): 218-221. Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic. (PMID 8980786)