rifamycin-resistant arabinosyltransferase [AMR Gene Family]

Accession ARO:3003464
DefinitionArabinosyl transferases allow for the polymerization of arabinose to form arabinan. Arabanan is required for formation of mycobacterial cell walls and arabinosyltransferases are targets of the drug ethambutol. Mutations in these genes can confer resistance to rifampicin.
Drug Classrifamycin antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ antibiotic resistant aftA
+ derives_from antibiotic sensitive aftA
+ confers_resistance_to_drug_class rifamycin antibiotic [Drug Class]
1 ontology terms | Show

Shi R, et al. 2007. Antimicrob Agents Chemother 51(12): 4515-4517. Lack of correlation between embB mutation and ethambutol MIC in Mycobacterium tuberculosis clinical isolates from China. (PMID 17846128)