lassomycin [Antibiotic]

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Accession ARO:3004295
DefinitionA ribosomally synthesized cyclic peptide antibiotic. Lassomycin has been shown to be effective against drug-resistant mycobacteria but shows little activity against other bacteria. Lassomycin targets and binds to a region of the ClpC1 ATPase complex and uncouples ATPase from proteolytic activity, an essential function for mycobacterial viability, causing cell death.
Drug Classrifamycin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ rifamycin antibiotic [Drug Class]

Gavrish E, et al. 2014. Chem. Biol. 21(4):509-518 Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. (PMID 24684906)