| Ontology | CARD's Antibiotic Resistance Ontology | ||||||||||
| Accession | ARO:3000559 | ||||||||||
| CARD Short Name | adeN | ||||||||||
| Definition | AdeN is a repressor of AdeIJK, a RND-type efflux pump in Acinetobacter baumannii. Its inactivation increases expression of AdeJ. | ||||||||||
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump, antibiotic efflux regulatory protein | ||||||||||
| Drug Class | penicillin beta-lactam, phenicol antibiotic, diaminopyrimidine antibiotic, rifamycin antibiotic, tetracycline antibiotic, carbapenem, cephalosporin, lincosamide antibiotic, fluoroquinolone antibiotic, macrolide antibiotic | ||||||||||
| Resistance Mechanism | antibiotic efflux | ||||||||||
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance | ||||||||||
| Efflux Regulator | protein(s) or two-component regulatory system modulating antibiotic efflux | ||||||||||
| CARD:Epi text mining of PubMed up to 2021 (top ten associations if supported by more than one publication) |
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| Classification | 26 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + beta-lactam antibiotic + mechanism of antibiotic resistance + penicillin beta-lactam [Drug Class] + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + penicillin with extended spectrum + phenicol antibiotic [Drug Class] + diaminopyrimidine antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + rifamycin antibiotic [Drug Class] + tetracycline antibiotic [Drug Class] + carbapenem [Drug Class] + ticarcillin [Antibiotic] + protein(s) or two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + chloramphenicol [Antibiotic] + trimethoprim [Antibiotic] + imipenem [Antibiotic] + rifampin [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + tetracycline [Antibiotic] + cephalosporin [Drug Class] + lincosamide antibiotic [Drug Class] + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] | ||||||||||
| Parent Term(s) | 2 ontology terms | Show | ||||||||||
| Resistomes with Sequence Variants | Acinetobacter baumanniig+p+wgs, Klebsiella pneumoniaewgs | ||||||||||
| Publications | Rosenfeld N, et al. 2012. Antimicrob Agents Chemother 56(5): 2504-2510. Expression of the resistance-nodulation-cell division pump AdeIJK in Acinetobacter baumannii is regulated by AdeN, a TetR-type regulator. (PMID 22371895) |
Prevalence of adeN among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
|---|---|---|---|---|---|
| Acinetobacter baumannii | 71.86% | 0.1% | 69.41% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 420
| Curator | Description | Most Recent Edit |
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