adeI

Accession ARO:3000780
DefinitionAdeI is the membrane fusion protein of the AdeIJK multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, diaminopyrimidine antibiotic, rifamycin antibiotic, carbapenem, phenicol antibiotic, penem, macrolide antibiotic, lincosamide antibiotic, fluoroquinolone antibiotic, cephalosporin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesAcinetobacter baumanniig+p+wgs
Classification25 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Damier-Piolle L, et al. 2008. Antimicrob Agents Chemother 52(2): 557-562. AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. (PMID 18086852)

Resistomes

Prevalence of adeI among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Acinetobacter baumannii98.73%0.29%99.68%
Acinetobacter nosocomialis100%0%100%
Klebsiella pneumoniae0%0%0%
Proteus mirabilis0%0%0%
Staphylococcus aureus0%0%0.01%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 800


>gb|ACJ41739.1|+|adeI [Acinetobacter baumannii AB0057]
MMSAKLWAPALTACALATSIALVGCSKGSDEKQQAAAAQKMPPAEVGVIVAQPQSVEQSVELSGRTSAYQISEVRPQTSGVILKRLFAEG
SYVREGQALYELDSRTNRATLENAKASLLQQQANLASLRTKLNRYKQLVSSNAVSKQEYDDLLGQVNVAEAQVAAAKAQVTNANVDLGYS
TIRSPISGQSGRSSVTAGALVTANQTDPLVTIQQLDPIYVDINQSSAELLRLRQQLSKGSLNNSNNTKVKLKLEDGSTYPIEGQLAFSDA
SVNQDTGTITLRAVFSNPNHLLLPGMYTTAQIVQGVVPNAYLIPQAAITRLPTGQAVAMLVNAKGVVESRPVETSGVQGQNWIVTNGLKA
GDKVIVDGVAKVKEGQEVSAKPYQAQPANSQGAAPNAAKPAQSGKPQAEQKAASNA


>gb|CP001182.2|+|3283427-3284677|adeI [Acinetobacter baumannii AB0057]
ATGATGTCGGCTAAGCTTTGGGCACCAGCCCTTACTGCTTGCGCATTAGCAACAAGTATCGCGCTTGTTGGTTGTAGCAAAGGCTCCGAT
GAGAAACAGCAAGCTGCTGCTGCTCAGAAAATGCCGCCTGCAGAAGTAGGTGTTATTGTTGCTCAACCACAAAGTGTTGAACAAAGCGTT
GAGCTTTCAGGCCGTACTTCAGCATATCAAATTTCTGAAGTTCGTCCTCAAACAAGTGGCGTGATTTTAAAACGTTTATTTGCTGAAGGA
AGCTATGTTCGTGAAGGTCAGGCGCTTTATGAGCTCGACTCTAGAACGAACCGTGCAACGTTAGAAAATGCAAAAGCATCACTCCTACAA
CAACAGGCAAATCTAGCTTCACTACGTACCAAGTTAAATCGTTATAAACAACTTGTTTCTAGTAATGCTGTGTCTAAACAGGAATATGAT
GACTTACTTGGTCAAGTCAATGTTGCAGAAGCACAAGTTGCAGCAGCTAAGGCTCAAGTAACAAATGCAAATGTAGATCTTGGTTATTCT
ACAATTCGCTCTCCTATTTCTGGCCAATCTGGTCGTTCTTCAGTAACGGCTGGTGCTTTGGTTACTGCAAACCAGACTGACCCGTTGGTA
ACGATTCAACAATTAGATCCTATCTATGTTGATATTAATCAGTCTAGTGCTGAGTTATTGCGTTTACGTCAACAACTAAGCAAAGGCAGT
TTAAATAACAGTAACAACACGAAAGTAAAATTAAAGCTTGAAGATGGTTCTACCTATCCAATCGAAGGGCAACTTGCTTTCTCTGACGCT
TCTGTAAACCAAGATACAGGAACAATTACATTACGTGCCGTATTCTCTAACCCGAATCATTTATTGCTTCCGGGTATGTATACCACTGCG
CAAATTGTTCAGGGCGTTGTTCCAAATGCTTACCTGATTCCTCAAGCTGCCATTACTCGTTTACCTACAGGACAAGCTGTAGCGATGCTT
GTTAATGCTAAAGGGGTTGTTGAGAGCCGTCCTGTTGAAACCTCTGGTGTTCAAGGACAAAACTGGATTGTGACTAACGGCTTAAAAGCC
GGCGATAAAGTCATTGTTGATGGTGTTGCCAAAGTTAAAGAAGGGCAAGAAGTATCAGCAAAACCTTATCAAGCTCAACCAGCAAACTCT
CAAGGTGCAGCACCAAATGCTGCGAAACCGGCTCAATCAGGTAAACCTCAAGCAGAACAGAAAGCAGCTTCAAATGCATAA