| Accession | ARO:3003809 |
| CARD Short Name | Abau_OprD_IPM |
| Definition | An outer member protein (OMP) found in Acinetobacter baumannii involved in the uptake of imipenem and basic amino acids. This porin is homologous to Pseudomonas aeruginosa OprD, which performs an identical function. |
| AMR Gene Family | Outer Membrane Porin (Opr) |
| Drug Class | penem, penam, cephamycin, cephalosporin, carbapenem, monobactam |
| Resistance Mechanism | reduced permeability to antibiotic, resistance by absence |
| Classification | 15 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + beta-lactam antibiotic + mechanism of antibiotic resistance + cephem + reduced permeability to antibiotic [Resistance Mechanism] + determinant of antibiotic resistance + resistance by absence [Resistance Mechanism] + penem [Drug Class] + protein modulating permeability to antibiotic + penam [Drug Class] + cephamycin [Drug Class] + cephalosporin [Drug Class] + carbapenem [Drug Class] + monobactam [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic imipenem [Antibiotic] + gene conferring resistance via absence + Outer Membrane Porin (Opr) [AMR Gene Family] |
| Publications | Dupont M, et al. . J. Proteome Res. 4(6):2386-90 Identification of an OprD homologue in Acinetobacter baumannii. (PMID 16335991) |
Prevalence of Acinetobacter baumannii OprD conferring resistance to imipenem among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein knockout model
Model Definition: Protein Knockout Models (PKM) reflect resistance by the absence of a gene product, most often deletion of a gene involved in antibiotic import, such as Vibrio cholerae OmpT. Like Protein Homolog Models (PHMs), PKMs include a reference sequence and a bitscore cut-off for detection using BLASTP but instead are designed to only report lack of detection under Perfect or Strict criteria. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff. This model type is still under development and not currently supported by the Resistance Gene Identifier (RGI) software.
Bit-score Cut-off (blastP): 800